Antimicrobial susceptibility of pathogens isolated from surgical site infections in Japan: Comparison of data from nationwide surveillance studies conducted in 2010 and 2014–2015

Yoshio Takesue, Shinya Kusachi, Hiroshige Mikamo, Junko Sato, Akira Watanabe, Hiroshi Kiyota, Satoshi Iwata, Mitsuo Kaku, Hideaki Hanaki, Yoshinobu Sumiyama, Yuukou Kitagawa, Toru Mizuguchi, Yoshiyasu Ambo, Masafumi Konosu, Keiichiro Ishibashi, Akihisa Matsuda, Kazuo Hase, Yasushi Harihara, Koji Okabayashi, Shiko SekiTakuo Hara, Koshi Matsui, Yoichi Matsuo, Minako Kobayashi, Shoji Kubo, Kazuhisa Uchiyama, Junzo Shimizu, Ryohei Kawabata, Hiroki Ohge, Shinji Akagi, Masaaki Oka, Toshiro Wakatsuki, Katsunori Suzuki, Kohji Okamoto, Katsunori Yanagihara

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

A nationwide survey was conducted in Japan from 2014 to 2015 to investigate the antimicrobial susceptibility of pathogens isolated from surgical site infections (SSI). The resulting data were compared with that obtained in an earlier survey, conducted in 2010. Seven main organisms were collected, and 883 isolates were studied. A significant reduction in methicillin resistance was observed among Staphylococcus aureus isolates, dropping from 72.5% in 2010 to 53.8% in 2014–2015 (p < 0.001). MRSA isolates with a vancomycin minimum inhibitory concentration (MIC) of 2 μg/mL accounted for 1.2% of all MRSA isolates, which was significantly lower than in 2010 (9.7%, p = 0.029). Of the Escherichia coli isolates, 23.0% produced an extended spectrum β-lactamase (ESBL) in the 2014–2015 survey, which was a significant increase from 9.5% in 2010 (p = 0.011). The geometric mean MICs for ESBL-producing isolates were 0.07 μg/mL for meropenem, 9.51 μg/mL for tazobactam/piperacillin, 0.15 μg/mL for flomoxef, and 1.56 μg/mL for gentamycin. There was a significant increase in the isolation rate of non-fragilis Bacteroides among Bacteroides fragilis group species between the two study periods (35.2% vs. 53.1%, p = 0.007). More than 90% of isolates belonging to the B. fragilis group remained susceptible to tazobactam/piperacillin, meropenem, and metronidazole. In contrast, lower levels of susceptibility were observed for cefmetazole (49.6%), moxifloxacin (61.9%), and clindamycin (46.9%). Non-fragilis Bacteroides isolates had lower rates of antibiotic susceptibility compared with B. fragilis. Overall, the surveillance data clarified trends in antimicrobial susceptibility for organisms commonly associated with SSI.

Original languageEnglish
Pages (from-to)339-348
Number of pages10
JournalJournal of Infection and Chemotherapy
Volume23
Issue number6
DOIs
Publication statusPublished - 2017 Jun 1

Fingerprint

meropenem
Surgical Wound Infection
Japan
Bacteroides
Methicillin-Resistant Staphylococcus aureus
Cefmetazole
Bacteroides fragilis
Methicillin Resistance
Clindamycin
Metronidazole
Microbial Sensitivity Tests
Vancomycin
Gentamicins
Staphylococcus aureus
Escherichia coli
Anti-Bacterial Agents
Surveys and Questionnaires
tazobactam drug combination piperacillin

Keywords

  • Antibiotic susceptibility
  • Bacteroides fragilis group
  • Surgical site infections
  • Surveillance

ASJC Scopus subject areas

  • Microbiology (medical)
  • Pharmacology (medical)
  • Infectious Diseases

Cite this

Antimicrobial susceptibility of pathogens isolated from surgical site infections in Japan : Comparison of data from nationwide surveillance studies conducted in 2010 and 2014–2015. / Takesue, Yoshio; Kusachi, Shinya; Mikamo, Hiroshige; Sato, Junko; Watanabe, Akira; Kiyota, Hiroshi; Iwata, Satoshi; Kaku, Mitsuo; Hanaki, Hideaki; Sumiyama, Yoshinobu; Kitagawa, Yuukou; Mizuguchi, Toru; Ambo, Yoshiyasu; Konosu, Masafumi; Ishibashi, Keiichiro; Matsuda, Akihisa; Hase, Kazuo; Harihara, Yasushi; Okabayashi, Koji; Seki, Shiko; Hara, Takuo; Matsui, Koshi; Matsuo, Yoichi; Kobayashi, Minako; Kubo, Shoji; Uchiyama, Kazuhisa; Shimizu, Junzo; Kawabata, Ryohei; Ohge, Hiroki; Akagi, Shinji; Oka, Masaaki; Wakatsuki, Toshiro; Suzuki, Katsunori; Okamoto, Kohji; Yanagihara, Katsunori.

In: Journal of Infection and Chemotherapy, Vol. 23, No. 6, 01.06.2017, p. 339-348.

Research output: Contribution to journalArticle

Takesue, Y, Kusachi, S, Mikamo, H, Sato, J, Watanabe, A, Kiyota, H, Iwata, S, Kaku, M, Hanaki, H, Sumiyama, Y, Kitagawa, Y, Mizuguchi, T, Ambo, Y, Konosu, M, Ishibashi, K, Matsuda, A, Hase, K, Harihara, Y, Okabayashi, K, Seki, S, Hara, T, Matsui, K, Matsuo, Y, Kobayashi, M, Kubo, S, Uchiyama, K, Shimizu, J, Kawabata, R, Ohge, H, Akagi, S, Oka, M, Wakatsuki, T, Suzuki, K, Okamoto, K & Yanagihara, K 2017, 'Antimicrobial susceptibility of pathogens isolated from surgical site infections in Japan: Comparison of data from nationwide surveillance studies conducted in 2010 and 2014–2015', Journal of Infection and Chemotherapy, vol. 23, no. 6, pp. 339-348. https://doi.org/10.1016/j.jiac.2017.03.010
Takesue, Yoshio ; Kusachi, Shinya ; Mikamo, Hiroshige ; Sato, Junko ; Watanabe, Akira ; Kiyota, Hiroshi ; Iwata, Satoshi ; Kaku, Mitsuo ; Hanaki, Hideaki ; Sumiyama, Yoshinobu ; Kitagawa, Yuukou ; Mizuguchi, Toru ; Ambo, Yoshiyasu ; Konosu, Masafumi ; Ishibashi, Keiichiro ; Matsuda, Akihisa ; Hase, Kazuo ; Harihara, Yasushi ; Okabayashi, Koji ; Seki, Shiko ; Hara, Takuo ; Matsui, Koshi ; Matsuo, Yoichi ; Kobayashi, Minako ; Kubo, Shoji ; Uchiyama, Kazuhisa ; Shimizu, Junzo ; Kawabata, Ryohei ; Ohge, Hiroki ; Akagi, Shinji ; Oka, Masaaki ; Wakatsuki, Toshiro ; Suzuki, Katsunori ; Okamoto, Kohji ; Yanagihara, Katsunori. / Antimicrobial susceptibility of pathogens isolated from surgical site infections in Japan : Comparison of data from nationwide surveillance studies conducted in 2010 and 2014–2015. In: Journal of Infection and Chemotherapy. 2017 ; Vol. 23, No. 6. pp. 339-348.
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abstract = "A nationwide survey was conducted in Japan from 2014 to 2015 to investigate the antimicrobial susceptibility of pathogens isolated from surgical site infections (SSI). The resulting data were compared with that obtained in an earlier survey, conducted in 2010. Seven main organisms were collected, and 883 isolates were studied. A significant reduction in methicillin resistance was observed among Staphylococcus aureus isolates, dropping from 72.5{\%} in 2010 to 53.8{\%} in 2014–2015 (p < 0.001). MRSA isolates with a vancomycin minimum inhibitory concentration (MIC) of 2 μg/mL accounted for 1.2{\%} of all MRSA isolates, which was significantly lower than in 2010 (9.7{\%}, p = 0.029). Of the Escherichia coli isolates, 23.0{\%} produced an extended spectrum β-lactamase (ESBL) in the 2014–2015 survey, which was a significant increase from 9.5{\%} in 2010 (p = 0.011). The geometric mean MICs for ESBL-producing isolates were 0.07 μg/mL for meropenem, 9.51 μg/mL for tazobactam/piperacillin, 0.15 μg/mL for flomoxef, and 1.56 μg/mL for gentamycin. There was a significant increase in the isolation rate of non-fragilis Bacteroides among Bacteroides fragilis group species between the two study periods (35.2{\%} vs. 53.1{\%}, p = 0.007). More than 90{\%} of isolates belonging to the B. fragilis group remained susceptible to tazobactam/piperacillin, meropenem, and metronidazole. In contrast, lower levels of susceptibility were observed for cefmetazole (49.6{\%}), moxifloxacin (61.9{\%}), and clindamycin (46.9{\%}). Non-fragilis Bacteroides isolates had lower rates of antibiotic susceptibility compared with B. fragilis. Overall, the surveillance data clarified trends in antimicrobial susceptibility for organisms commonly associated with SSI.",
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T2 - Comparison of data from nationwide surveillance studies conducted in 2010 and 2014–2015

AU - Takesue, Yoshio

AU - Kusachi, Shinya

AU - Mikamo, Hiroshige

AU - Sato, Junko

AU - Watanabe, Akira

AU - Kiyota, Hiroshi

AU - Iwata, Satoshi

AU - Kaku, Mitsuo

AU - Hanaki, Hideaki

AU - Sumiyama, Yoshinobu

AU - Kitagawa, Yuukou

AU - Mizuguchi, Toru

AU - Ambo, Yoshiyasu

AU - Konosu, Masafumi

AU - Ishibashi, Keiichiro

AU - Matsuda, Akihisa

AU - Hase, Kazuo

AU - Harihara, Yasushi

AU - Okabayashi, Koji

AU - Seki, Shiko

AU - Hara, Takuo

AU - Matsui, Koshi

AU - Matsuo, Yoichi

AU - Kobayashi, Minako

AU - Kubo, Shoji

AU - Uchiyama, Kazuhisa

AU - Shimizu, Junzo

AU - Kawabata, Ryohei

AU - Ohge, Hiroki

AU - Akagi, Shinji

AU - Oka, Masaaki

AU - Wakatsuki, Toshiro

AU - Suzuki, Katsunori

AU - Okamoto, Kohji

AU - Yanagihara, Katsunori

PY - 2017/6/1

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N2 - A nationwide survey was conducted in Japan from 2014 to 2015 to investigate the antimicrobial susceptibility of pathogens isolated from surgical site infections (SSI). The resulting data were compared with that obtained in an earlier survey, conducted in 2010. Seven main organisms were collected, and 883 isolates were studied. A significant reduction in methicillin resistance was observed among Staphylococcus aureus isolates, dropping from 72.5% in 2010 to 53.8% in 2014–2015 (p < 0.001). MRSA isolates with a vancomycin minimum inhibitory concentration (MIC) of 2 μg/mL accounted for 1.2% of all MRSA isolates, which was significantly lower than in 2010 (9.7%, p = 0.029). Of the Escherichia coli isolates, 23.0% produced an extended spectrum β-lactamase (ESBL) in the 2014–2015 survey, which was a significant increase from 9.5% in 2010 (p = 0.011). The geometric mean MICs for ESBL-producing isolates were 0.07 μg/mL for meropenem, 9.51 μg/mL for tazobactam/piperacillin, 0.15 μg/mL for flomoxef, and 1.56 μg/mL for gentamycin. There was a significant increase in the isolation rate of non-fragilis Bacteroides among Bacteroides fragilis group species between the two study periods (35.2% vs. 53.1%, p = 0.007). More than 90% of isolates belonging to the B. fragilis group remained susceptible to tazobactam/piperacillin, meropenem, and metronidazole. In contrast, lower levels of susceptibility were observed for cefmetazole (49.6%), moxifloxacin (61.9%), and clindamycin (46.9%). Non-fragilis Bacteroides isolates had lower rates of antibiotic susceptibility compared with B. fragilis. Overall, the surveillance data clarified trends in antimicrobial susceptibility for organisms commonly associated with SSI.

AB - A nationwide survey was conducted in Japan from 2014 to 2015 to investigate the antimicrobial susceptibility of pathogens isolated from surgical site infections (SSI). The resulting data were compared with that obtained in an earlier survey, conducted in 2010. Seven main organisms were collected, and 883 isolates were studied. A significant reduction in methicillin resistance was observed among Staphylococcus aureus isolates, dropping from 72.5% in 2010 to 53.8% in 2014–2015 (p < 0.001). MRSA isolates with a vancomycin minimum inhibitory concentration (MIC) of 2 μg/mL accounted for 1.2% of all MRSA isolates, which was significantly lower than in 2010 (9.7%, p = 0.029). Of the Escherichia coli isolates, 23.0% produced an extended spectrum β-lactamase (ESBL) in the 2014–2015 survey, which was a significant increase from 9.5% in 2010 (p = 0.011). The geometric mean MICs for ESBL-producing isolates were 0.07 μg/mL for meropenem, 9.51 μg/mL for tazobactam/piperacillin, 0.15 μg/mL for flomoxef, and 1.56 μg/mL for gentamycin. There was a significant increase in the isolation rate of non-fragilis Bacteroides among Bacteroides fragilis group species between the two study periods (35.2% vs. 53.1%, p = 0.007). More than 90% of isolates belonging to the B. fragilis group remained susceptible to tazobactam/piperacillin, meropenem, and metronidazole. In contrast, lower levels of susceptibility were observed for cefmetazole (49.6%), moxifloxacin (61.9%), and clindamycin (46.9%). Non-fragilis Bacteroides isolates had lower rates of antibiotic susceptibility compared with B. fragilis. Overall, the surveillance data clarified trends in antimicrobial susceptibility for organisms commonly associated with SSI.

KW - Antibiotic susceptibility

KW - Bacteroides fragilis group

KW - Surgical site infections

KW - Surveillance

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