Antioxidant activity and xanthine oxidase inhibition activity of reductic acid: Ascorbic acid analogue

Tadahiko Mashino, Yasushi Takigawa, Naomi Saito, Liquing Q. Wong, Masataka Mochizuki

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Reductic acid (2,3-dihydroxy-2-cyclopentenone, 1) decreased the ESR signal of 5,5-dimethyl-1-pyrroline 1-oxide (DMPO)-OH produced by hydroxyl radical and DMPO. 1 also inhibited lipid peroxidation initiated by cytochrome P450 and tertbutyl hydroperoxide. 1 inhibited xanthine oxidase activity, while ascorbic acid and 2-hydroxytetronic acid, an ascorbic acid analogue without side chain, did not. (C) 2000 Elsevier Science Ltd.

Original languageEnglish
Pages (from-to)2783-2785
Number of pages3
JournalBioorganic and Medicinal Chemistry Letters
Volume10
Issue number24
DOIs
Publication statusPublished - 2000 Dec 18

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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