Antioxidative activity of indenestrol a, a diethylstilbestrol metabolite

Taiko Oda, Megumi Ebata, Shigenobu Matsumoto, Shiro Urano, Yoshihiro Sato

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)

Abstract

To elucidate the various activities of synthetic estrogens, the antioxidative activities of diethylstilbestrol (DES) and related metabolic analogs were examined. The antioxidative activities were assessed in terms of the inhibitory effect on Fe2+- and ascorbic acid-induced peroxidation of egg phosphatidylcholine (egg PC), and also superoxide scavenging ability using cyclic voltametry. Moreover, after in vivo administration of the test compounds to mice, the animals were subjected to hyperoxia, and catalase, glutathione peroxidase and superoxide dismutase activities in the brain, lungs and liver were measured. The results indicated that indenestrol A, one of the metabolites of DES, had the strongest antioxidative activity among the test compounds under both in vivo and in vitro conditions.

Original languageEnglish
Pages (from-to)586-589
Number of pages4
JournalBiological and Pharmaceutical Bulletin
Volume22
Issue number6
DOIs
Publication statusPublished - 1999 Jun

Keywords

  • Antioxidative activity
  • Catalase
  • Glutathione peroxidase
  • Indenestrol A
  • Superoxide dismutase
  • Thiobarbituric acid reactive substance

ASJC Scopus subject areas

  • Pharmacology
  • Pharmaceutical Science

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