Abstract
Effects of doping with fluorine to diamond-like carbon (DLC) films on the antithrombogenicity were investigated by changing its content. Fluorinated DLC (F-DLC) films were prepared on silicon (Si) substrates using radio frequency (RF) plasma enhanced chemical vapour deposition (CVD) by changing the ratio of hexafluoroethane (C2F6) and acetylene (C2H 2). The contact angle measurements of human whole blood droplet on Si, DLC and F-DLC were 24.2°, 60.8° and 95.3°, respectively. Furthermore, the static evaluation of F-DLC films incubated with platelet-rich plasma (PRP) showed dramatic reduction of platelet adhesion and activation on the surface. It was found that the addition of fluorine into DLC films much improved antithrombogenicity, which was clearly shown by scanning electron microscopy (SEM) with statistical analysis. F-DLC coating can be a great candidate for developing antithrombogenic surfaces in blood contacting materials.
| Original language | English |
|---|---|
| Pages (from-to) | 1116-1119 |
| Number of pages | 4 |
| Journal | Diamond and Related Materials |
| Volume | 14 |
| Issue number | 3-7 |
| DOIs | |
| Publication status | Published - 2005 Mar |
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Keywords
- Antithrombogenicity
- Fluorinated diamond-like carbon
- Hydrophobicity
- Platelet adhesion
ASJC Scopus subject areas
- Electronic, Optical and Magnetic Materials
- Materials Chemistry
- Surfaces, Coatings and Films
- Surfaces and Interfaces
Cite this
Antithrombogenicity of fluorinated diamond-like carbon films. / Saito, T.; Hasebe, T.; Yohena, S.; Matsuoka, Y.; Kamijo, A.; Takahashi, K.; Suzuki, Tetsuya.
In: Diamond and Related Materials, Vol. 14, No. 3-7, 03.2005, p. 1116-1119.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Antithrombogenicity of fluorinated diamond-like carbon films
AU - Saito, T.
AU - Hasebe, T.
AU - Yohena, S.
AU - Matsuoka, Y.
AU - Kamijo, A.
AU - Takahashi, K.
AU - Suzuki, Tetsuya
PY - 2005/3
Y1 - 2005/3
N2 - Effects of doping with fluorine to diamond-like carbon (DLC) films on the antithrombogenicity were investigated by changing its content. Fluorinated DLC (F-DLC) films were prepared on silicon (Si) substrates using radio frequency (RF) plasma enhanced chemical vapour deposition (CVD) by changing the ratio of hexafluoroethane (C2F6) and acetylene (C2H 2). The contact angle measurements of human whole blood droplet on Si, DLC and F-DLC were 24.2°, 60.8° and 95.3°, respectively. Furthermore, the static evaluation of F-DLC films incubated with platelet-rich plasma (PRP) showed dramatic reduction of platelet adhesion and activation on the surface. It was found that the addition of fluorine into DLC films much improved antithrombogenicity, which was clearly shown by scanning electron microscopy (SEM) with statistical analysis. F-DLC coating can be a great candidate for developing antithrombogenic surfaces in blood contacting materials.
AB - Effects of doping with fluorine to diamond-like carbon (DLC) films on the antithrombogenicity were investigated by changing its content. Fluorinated DLC (F-DLC) films were prepared on silicon (Si) substrates using radio frequency (RF) plasma enhanced chemical vapour deposition (CVD) by changing the ratio of hexafluoroethane (C2F6) and acetylene (C2H 2). The contact angle measurements of human whole blood droplet on Si, DLC and F-DLC were 24.2°, 60.8° and 95.3°, respectively. Furthermore, the static evaluation of F-DLC films incubated with platelet-rich plasma (PRP) showed dramatic reduction of platelet adhesion and activation on the surface. It was found that the addition of fluorine into DLC films much improved antithrombogenicity, which was clearly shown by scanning electron microscopy (SEM) with statistical analysis. F-DLC coating can be a great candidate for developing antithrombogenic surfaces in blood contacting materials.
KW - Antithrombogenicity
KW - Fluorinated diamond-like carbon
KW - Hydrophobicity
KW - Platelet adhesion
UR - http://www.scopus.com/inward/record.url?scp=18444411390&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=18444411390&partnerID=8YFLogxK
U2 - 10.1016/j.diamond.2004.09.017
DO - 10.1016/j.diamond.2004.09.017
M3 - Article
AN - SCOPUS:18444411390
VL - 14
SP - 1116
EP - 1119
JO - Diamond and Related Materials
JF - Diamond and Related Materials
SN - 0925-9635
IS - 3-7
ER -