Antithrombogenicity of fluorinated diamond-like carbon films

T. Saito; T. Hasebe; S. Yohena; Y. Matsuoka; A. Kamijo; K. Takahashi; T. Suzuki

doi:10.1016/j.diamond.2004.09.017

Antithrombogenicity of fluorinated diamond-like carbon films

T. Saito, T. Hasebe, S. Yohena, Y. Matsuoka, A. Kamijo, K. Takahashi, T. Suzuki

Department of Mechanical Engineering

Research output: Contribution to journal › Article › peer-review

102 Citations (Scopus)

Abstract

Effects of doping with fluorine to diamond-like carbon (DLC) films on the antithrombogenicity were investigated by changing its content. Fluorinated DLC (F-DLC) films were prepared on silicon (Si) substrates using radio frequency (RF) plasma enhanced chemical vapour deposition (CVD) by changing the ratio of hexafluoroethane (C₂F₆) and acetylene (C₂H ₂). The contact angle measurements of human whole blood droplet on Si, DLC and F-DLC were 24.2°, 60.8° and 95.3°, respectively. Furthermore, the static evaluation of F-DLC films incubated with platelet-rich plasma (PRP) showed dramatic reduction of platelet adhesion and activation on the surface. It was found that the addition of fluorine into DLC films much improved antithrombogenicity, which was clearly shown by scanning electron microscopy (SEM) with statistical analysis. F-DLC coating can be a great candidate for developing antithrombogenic surfaces in blood contacting materials.

Original language	English
Pages (from-to)	1116-1119
Number of pages	4
Journal	Diamond and Related Materials
Volume	14
Issue number	3-7
DOIs	https://doi.org/10.1016/j.diamond.2004.09.017
Publication status	Published - 2005 Mar

Keywords

Antithrombogenicity
Fluorinated diamond-like carbon
Hydrophobicity
Platelet adhesion

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Chemistry(all)
Mechanical Engineering
Materials Chemistry
Electrical and Electronic Engineering

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title = "Antithrombogenicity of fluorinated diamond-like carbon films",

abstract = "Effects of doping with fluorine to diamond-like carbon (DLC) films on the antithrombogenicity were investigated by changing its content. Fluorinated DLC (F-DLC) films were prepared on silicon (Si) substrates using radio frequency (RF) plasma enhanced chemical vapour deposition (CVD) by changing the ratio of hexafluoroethane (C2F6) and acetylene (C2H 2). The contact angle measurements of human whole blood droplet on Si, DLC and F-DLC were 24.2°, 60.8° and 95.3°, respectively. Furthermore, the static evaluation of F-DLC films incubated with platelet-rich plasma (PRP) showed dramatic reduction of platelet adhesion and activation on the surface. It was found that the addition of fluorine into DLC films much improved antithrombogenicity, which was clearly shown by scanning electron microscopy (SEM) with statistical analysis. F-DLC coating can be a great candidate for developing antithrombogenic surfaces in blood contacting materials.",

keywords = "Antithrombogenicity, Fluorinated diamond-like carbon, Hydrophobicity, Platelet adhesion",

author = "T. Saito and T. Hasebe and S. Yohena and Y. Matsuoka and A. Kamijo and K. Takahashi and T. Suzuki",

year = "2005",

month = mar,

doi = "10.1016/j.diamond.2004.09.017",

language = "English",

volume = "14",

pages = "1116--1119",

journal = "Diamond and Related Materials",

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TY - JOUR

T1 - Antithrombogenicity of fluorinated diamond-like carbon films

AU - Saito, T.

AU - Hasebe, T.

AU - Yohena, S.

AU - Matsuoka, Y.

AU - Kamijo, A.

AU - Takahashi, K.

AU - Suzuki, T.

PY - 2005/3

Y1 - 2005/3

N2 - Effects of doping with fluorine to diamond-like carbon (DLC) films on the antithrombogenicity were investigated by changing its content. Fluorinated DLC (F-DLC) films were prepared on silicon (Si) substrates using radio frequency (RF) plasma enhanced chemical vapour deposition (CVD) by changing the ratio of hexafluoroethane (C2F6) and acetylene (C2H 2). The contact angle measurements of human whole blood droplet on Si, DLC and F-DLC were 24.2°, 60.8° and 95.3°, respectively. Furthermore, the static evaluation of F-DLC films incubated with platelet-rich plasma (PRP) showed dramatic reduction of platelet adhesion and activation on the surface. It was found that the addition of fluorine into DLC films much improved antithrombogenicity, which was clearly shown by scanning electron microscopy (SEM) with statistical analysis. F-DLC coating can be a great candidate for developing antithrombogenic surfaces in blood contacting materials.

AB - Effects of doping with fluorine to diamond-like carbon (DLC) films on the antithrombogenicity were investigated by changing its content. Fluorinated DLC (F-DLC) films were prepared on silicon (Si) substrates using radio frequency (RF) plasma enhanced chemical vapour deposition (CVD) by changing the ratio of hexafluoroethane (C2F6) and acetylene (C2H 2). The contact angle measurements of human whole blood droplet on Si, DLC and F-DLC were 24.2°, 60.8° and 95.3°, respectively. Furthermore, the static evaluation of F-DLC films incubated with platelet-rich plasma (PRP) showed dramatic reduction of platelet adhesion and activation on the surface. It was found that the addition of fluorine into DLC films much improved antithrombogenicity, which was clearly shown by scanning electron microscopy (SEM) with statistical analysis. F-DLC coating can be a great candidate for developing antithrombogenic surfaces in blood contacting materials.

KW - Antithrombogenicity

KW - Fluorinated diamond-like carbon

KW - Hydrophobicity

KW - Platelet adhesion

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DO - 10.1016/j.diamond.2004.09.017

M3 - Article

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JO - Diamond and Related Materials

JF - Diamond and Related Materials

SN - 0925-9635

IS - 3-7

ER -

Antithrombogenicity of fluorinated diamond-like carbon films

Abstract

Keywords

ASJC Scopus subject areas

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