Antithrombogenicity of fluorinated diamond-like carbon films

T. Saito, T. Hasebe, S. Yohena, Y. Matsuoka, A. Kamijo, K. Takahashi, Tetsuya Suzuki

Research output: Contribution to journalArticle

97 Citations (Scopus)

Abstract

Effects of doping with fluorine to diamond-like carbon (DLC) films on the antithrombogenicity were investigated by changing its content. Fluorinated DLC (F-DLC) films were prepared on silicon (Si) substrates using radio frequency (RF) plasma enhanced chemical vapour deposition (CVD) by changing the ratio of hexafluoroethane (C2F6) and acetylene (C2H 2). The contact angle measurements of human whole blood droplet on Si, DLC and F-DLC were 24.2°, 60.8° and 95.3°, respectively. Furthermore, the static evaluation of F-DLC films incubated with platelet-rich plasma (PRP) showed dramatic reduction of platelet adhesion and activation on the surface. It was found that the addition of fluorine into DLC films much improved antithrombogenicity, which was clearly shown by scanning electron microscopy (SEM) with statistical analysis. F-DLC coating can be a great candidate for developing antithrombogenic surfaces in blood contacting materials.

Original languageEnglish
Pages (from-to)1116-1119
Number of pages4
JournalDiamond and Related Materials
Volume14
Issue number3-7
DOIs
Publication statusPublished - 2005 Mar

Fingerprint

Diamond like carbon films
Fluorine
diamonds
Silicon
Platelets
carbon
Blood
platelets
blood
fluorine
Acetylene
Diamond
Plasma enhanced chemical vapor deposition
Angle measurement
Contact angle
Diamonds
Statistical methods
silicon
Carbon
Adhesion

Keywords

  • Antithrombogenicity
  • Fluorinated diamond-like carbon
  • Hydrophobicity
  • Platelet adhesion

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Materials Chemistry
  • Surfaces, Coatings and Films
  • Surfaces and Interfaces

Cite this

Saito, T., Hasebe, T., Yohena, S., Matsuoka, Y., Kamijo, A., Takahashi, K., & Suzuki, T. (2005). Antithrombogenicity of fluorinated diamond-like carbon films. Diamond and Related Materials, 14(3-7), 1116-1119. https://doi.org/10.1016/j.diamond.2004.09.017

Antithrombogenicity of fluorinated diamond-like carbon films. / Saito, T.; Hasebe, T.; Yohena, S.; Matsuoka, Y.; Kamijo, A.; Takahashi, K.; Suzuki, Tetsuya.

In: Diamond and Related Materials, Vol. 14, No. 3-7, 03.2005, p. 1116-1119.

Research output: Contribution to journalArticle

Saito, T, Hasebe, T, Yohena, S, Matsuoka, Y, Kamijo, A, Takahashi, K & Suzuki, T 2005, 'Antithrombogenicity of fluorinated diamond-like carbon films', Diamond and Related Materials, vol. 14, no. 3-7, pp. 1116-1119. https://doi.org/10.1016/j.diamond.2004.09.017
Saito T, Hasebe T, Yohena S, Matsuoka Y, Kamijo A, Takahashi K et al. Antithrombogenicity of fluorinated diamond-like carbon films. Diamond and Related Materials. 2005 Mar;14(3-7):1116-1119. https://doi.org/10.1016/j.diamond.2004.09.017
Saito, T. ; Hasebe, T. ; Yohena, S. ; Matsuoka, Y. ; Kamijo, A. ; Takahashi, K. ; Suzuki, Tetsuya. / Antithrombogenicity of fluorinated diamond-like carbon films. In: Diamond and Related Materials. 2005 ; Vol. 14, No. 3-7. pp. 1116-1119.
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