Antithrombogenicity of fluorinated diamond-like carbon films

T. Saito, T. Hasebe, S. Yohena, Y. Matsuoka, A. Kamijo, K. Takahashi, T. Suzuki

Research output: Contribution to journalArticle

99 Citations (Scopus)

Abstract

Effects of doping with fluorine to diamond-like carbon (DLC) films on the antithrombogenicity were investigated by changing its content. Fluorinated DLC (F-DLC) films were prepared on silicon (Si) substrates using radio frequency (RF) plasma enhanced chemical vapour deposition (CVD) by changing the ratio of hexafluoroethane (C2F6) and acetylene (C2H 2). The contact angle measurements of human whole blood droplet on Si, DLC and F-DLC were 24.2°, 60.8° and 95.3°, respectively. Furthermore, the static evaluation of F-DLC films incubated with platelet-rich plasma (PRP) showed dramatic reduction of platelet adhesion and activation on the surface. It was found that the addition of fluorine into DLC films much improved antithrombogenicity, which was clearly shown by scanning electron microscopy (SEM) with statistical analysis. F-DLC coating can be a great candidate for developing antithrombogenic surfaces in blood contacting materials.

Original languageEnglish
Pages (from-to)1116-1119
Number of pages4
JournalDiamond and Related Materials
Volume14
Issue number3-7
DOIs
Publication statusPublished - 2005 Mar

Keywords

  • Antithrombogenicity
  • Fluorinated diamond-like carbon
  • Hydrophobicity
  • Platelet adhesion

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Chemistry(all)
  • Mechanical Engineering
  • Materials Chemistry
  • Electrical and Electronic Engineering

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  • Cite this

    Saito, T., Hasebe, T., Yohena, S., Matsuoka, Y., Kamijo, A., Takahashi, K., & Suzuki, T. (2005). Antithrombogenicity of fluorinated diamond-like carbon films. Diamond and Related Materials, 14(3-7), 1116-1119. https://doi.org/10.1016/j.diamond.2004.09.017