Antithrombogenicity of fluorinated diamond-like carbon films coated nano porous polyethersulfone (PES) membrane

Gunawan S. Prihandana, Ippei Sanada, Hikaru Ito, Mayui Noborisaka, Yoshihiko Kanno, Tetsuya Suzuki, Norihisa Miki

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

A nano porous polyethersulfone (PES) membrane is widely used for aspects of nanofiltration, such as purification, fractionation and dialysis. However, the low-blood-compatibility characteristic of PES membrane causes platelets and blood cells to stick to the surface of the membrane and degrades ions diffusion through membrane, which further limits its application for dialysis systems. In this study, we deposited the fluorinated-diamond-like-carbon (F-DLC) onto the finger like structure layer of the PES membrane. By doing this, we have the F-DLC films coating the membrane surface without sacrificing the membrane permeability. In addition, we examined antithrombogenicity of the F-DLC/PES membranes using a microfluidic device, and experimentally found that F-DLC drastically reduced the amount of blood cells attached to the surface. We have also conducted long-term experiments for 24 days and the diffusion characteristics were found to be deteriorated due to fouling without any surface modification. On the other hand, the membranes coated by F-DLC film gave a consistent diffusion coefficient of ions transfer through a membrane porous. Therefore, F-DLC films can be a great candidate to improve the antithrombogenic characteristics of the membrane surfaces in hemodialysis systems.

Original languageEnglish
Pages (from-to)4309-4323
Number of pages15
JournalMaterials
Volume6
Issue number10
DOIs
Publication statusPublished - 2013 Dec 5

Keywords

  • Blood compatibility
  • Fluorinated diamond-like carbon
  • Nano porous polyethersulfone
  • Surface modification

ASJC Scopus subject areas

  • Materials Science(all)

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