Antithrombogenicity of nano porous polyethersulfone membrane coated with fluorinated diamond-like carbon

I. Sanada, H. Ito, G. S. Prihandana, M. Noborisaka, N. Miki, T. Suzuki, Y. Kanno

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

We have ever developed micro dialysis system that consists of micro channels and polyethersulfone (PES) membranes. However, when blood was used in dialysis experiments, platelets adhered to the surface of membrane and performance of the membrane degraded. Therefore, we modify the surface of PES membranes by coating fluorinated diamond-like carbon (F-DLC). We examined antithrombogencity of the F-DLC/PES membranes using a microfluidic device and experimentally found that F-DLC drastically reduced the amount of cells attached to the surface. We conducted long-term experiments for 1 week and the diffusion characteristics were found to retrogress because of fouling without the surface modification.

Original languageEnglish
Title of host publication17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013
PublisherChemical and Biological Microsystems Society
Pages808-810
Number of pages3
ISBN (Print)9781632666246
Publication statusPublished - 2013 Jan 1
Event17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013 - Freiburg, Germany
Duration: 2013 Oct 272013 Oct 31

Publication series

Name17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013
Volume2

Other

Other17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013
CountryGermany
CityFreiburg
Period13/10/2713/10/31

Keywords

  • Dialysis system
  • Fluorinated diamond-like carbon
  • Nano porous polyethersulfone membrane

ASJC Scopus subject areas

  • Bioengineering

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