Antitumor Activity of Erbstatin, A Tyrosine Protein Kinase Inhibitor

Masaya Imoto, Keiko Komuro, Tsutomu Sawa, Tomio Takeuchi, Hamao Umezawa, Kazuo Umezawa

Research output: Contribution to journalArticle

50 Citations (Scopus)

Abstract

A tyrosine protein kinase inhibitor, erbstatin, showed no antineoplastic effect on L-1210 mouse leukemia when it was injected alone. Erbstatin was found to be inactivated by incubation in serum, but not in dialyzed serum. It was also inactivated in reconstituted serum containing dialyzed serum components and ferric or ferrous ion. Because erbstatin was considered to be inactivated by the ferric or ferrous ion in serum, foroxymithine, which is a potent chelator for the ferric ion, was given to the mice together with erbstatin. Administration of both erbstatin and foroxymithine showed antineoplastic activity against L-1210 leukemia.

Original languageEnglish
Pages (from-to)329-332
Number of pages4
JournalJapanese Journal of Cancer Research
Volume78
Issue number4
Publication statusPublished - 1987 Jan 1
Externally publishedYes

    Fingerprint

Keywords

  • Antitumor activity
  • Erbstatin
  • Foroxymithine
  • L-1210 leukemia

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Imoto, M., Komuro, K., Sawa, T., Takeuchi, T., Umezawa, H., & Umezawa, K. (1987). Antitumor Activity of Erbstatin, A Tyrosine Protein Kinase Inhibitor. Japanese Journal of Cancer Research, 78(4), 329-332.