Antitumor Activity of Erbstatin, A Tyrosine Protein Kinase Inhibitor

Masaya Imoto; Keiko Komuro; Tsutomu Sawa; Tomio Takeuchi; Hamao Umezawa; Kazuo Umezawa

Antitumor Activity of Erbstatin, A Tyrosine Protein Kinase Inhibitor

Masaya Imoto, Keiko Komuro, Tsutomu Sawa, Tomio Takeuchi, Hamao Umezawa, Kazuo Umezawa

Research output: Contribution to journal › Article › peer-review

Abstract

A tyrosine protein kinase inhibitor, erbstatin, showed no antineoplastic effect on L-1210 mouse leukemia when it was injected alone. Erbstatin was found to be inactivated by incubation in serum, but not in dialyzed serum. It was also inactivated in reconstituted serum containing dialyzed serum components and ferric or ferrous ion. Because erbstatin was considered to be inactivated by the ferric or ferrous ion in serum, foroxymithine, which is a potent chelator for the ferric ion, was given to the mice together with erbstatin. Administration of both erbstatin and foroxymithine showed antineoplastic activity against L-1210 leukemia.

Original language	English
Pages (from-to)	329-332
Number of pages	4
Journal	Japanese Journal of Cancer Research
Volume	78
Issue number	4
Publication status	Published - 1987 Jan 1
Externally published	Yes

Keywords

Antitumor activity
Erbstatin
Foroxymithine
L-1210 leukemia

ASJC Scopus subject areas

Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Cite this

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T1 - Antitumor Activity of Erbstatin, A Tyrosine Protein Kinase Inhibitor

AU - Imoto, Masaya

AU - Komuro, Keiko

AU - Sawa, Tsutomu

AU - Takeuchi, Tomio

AU - Umezawa, Hamao

AU - Umezawa, Kazuo

PY - 1987/1/1

Y1 - 1987/1/1

N2 - A tyrosine protein kinase inhibitor, erbstatin, showed no antineoplastic effect on L-1210 mouse leukemia when it was injected alone. Erbstatin was found to be inactivated by incubation in serum, but not in dialyzed serum. It was also inactivated in reconstituted serum containing dialyzed serum components and ferric or ferrous ion. Because erbstatin was considered to be inactivated by the ferric or ferrous ion in serum, foroxymithine, which is a potent chelator for the ferric ion, was given to the mice together with erbstatin. Administration of both erbstatin and foroxymithine showed antineoplastic activity against L-1210 leukemia.

AB - A tyrosine protein kinase inhibitor, erbstatin, showed no antineoplastic effect on L-1210 mouse leukemia when it was injected alone. Erbstatin was found to be inactivated by incubation in serum, but not in dialyzed serum. It was also inactivated in reconstituted serum containing dialyzed serum components and ferric or ferrous ion. Because erbstatin was considered to be inactivated by the ferric or ferrous ion in serum, foroxymithine, which is a potent chelator for the ferric ion, was given to the mice together with erbstatin. Administration of both erbstatin and foroxymithine showed antineoplastic activity against L-1210 leukemia.

KW - Antitumor activity

KW - Erbstatin

KW - Foroxymithine

KW - L-1210 leukemia

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Antitumor Activity of Erbstatin, A Tyrosine Protein Kinase Inhibitor

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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