Antitumor effect of piericidin B1 N-oxide

Hiroshi Nishioka, Tsutomu Sawa, Tomio Takeuchi, Masaya Imoto, Tomomi Imaoka, Kazuo Umezawa

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16 Citations (Scopus)

Abstract

Piericidin B1 N-oxide was isolated from a culture broth of Streptomyces sp. as a novel inhibitor of phosphatidylinositol (PI) turnover. Piericidin B1 N-oxide specifically inhibited orthophosphate labeling of PI induced by epidermal growth factor (EGF) without affecting the formation of phosphatidic acid (PA). Like piericidins A1 and B1, piericidin B1 N-oxide inhibited ATP synthesis in A431 cells; however, the effect of piericidin B1 N-oxide on PI synthesis was stronger than that of piericidins A1 and B1. At the concentration inhibiting PI synthesis, piericidin B1 N-oxide showed no inhibitory effect on DNA, RNA, or protein synthesis. We also demonstrated that piericidin B1 N-oxide reversibly inhibited the growth of A431 cells in situ and suppressed the growth of Ehrlich carcinoma in vivo when administered to mice by intraperitoneal (ip) injection.

Original languageEnglish
Pages (from-to)447-452
Number of pages6
JournalThe Journal of Antibiotics
Volume47
Issue number4
DOIs
Publication statusPublished - 1994 Jan 1

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery

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    Nishioka, H., Sawa, T., Takeuchi, T., Imoto, M., Imaoka, T., & Umezawa, K. (1994). Antitumor effect of piericidin B1 N-oxide. The Journal of Antibiotics, 47(4), 447-452. https://doi.org/10.7164/antibiotics.47.447