Aplyronine A, a potent antitumour macrolide of marine origin, and the congeners aplyronines B-H: Chemistry and biology

Kiyoyuki Yamada, Makoto Ojika, Hideo Kigoshi, Kiyotake Suenaga

Research output: Contribution to journalReview article

37 Citations (Scopus)

Abstract

Aplyronines A-H are cytotoxic macrolides isolated from the sea hare Aplysia kurodai. Aplyronine A is the major constituent among the aplyronines, and this review concentrates on the results of chemical and biological research into this natural product. The isolation, determination of stereostructure and enantioselective total synthesis of the aplyronines are covered, together with discussion of their antitumour activity and structure-activity relationships, and the three-dimensional X-ray structure of the actin-aplyronine A complex.

Original languageEnglish
Pages (from-to)27-43
Number of pages17
JournalNatural Product Reports
Volume26
Issue number1
DOIs
Publication statusPublished - 2009 Jan 6

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ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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