Apocrine carcinoma of the breast: Clinicopathological analysis and histological subclassification of 12 cases

Kaneyuki Matsuo, Takashi Fukutomi, Hitoshi Tsuda, Yae Kanai, Sadako Akashi-Tanaka, Takeshi Nanasawa

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Background: Apocrine carcinoma is rare and most of its clinicopathological features are still unknown. The purpose of this study was to identify the clinicopathological characteristics of apocrine carcinoma. Methods: We clinicopathologically analyzed apocrine breast carcinomas resected from 12 Japanese women and subclassified them histopathologically. Results: The average age of the patients at diagnosis was 60.1 years (range: 38-78). Tumor diameters ranged from 0.5 to 4.5 cm (median 2.4). Mammography revealed tumor shadows without microcalcifications in all patients. Two (17%) of the 12 patients were lymph node metastasis-positive, and lymphatic permeation by tumor cells was observed in 3 (25%). Apocrine carcinoma in this study could be classified into three subtypes according to predominant histopathological growth pattern: type I, intraductal spreading type (4 patients); type II, adenosis-associated type (3 patients); and type III, infiltrating type (5 patients). Types I and II showed no lymph node metastasis and had an excellent prognosis, whereas the infiltrating type was associated with lymph node metastasis and death from cancer. Estrogen receptors and progesterone receptors were positive in 17% (1/6) and 60% (3/5), respectively, of the tumors tested. Conclusions: In the present study, apocrine carcinoma of the breast was characterized by higher patient age and tumor shadows without microcalcifications on mammography. However, the tumors were heterogenous with regard to pattern of local spread.

Original languageEnglish
Pages (from-to)279-284
Number of pages6
JournalBreast Cancer
Volume5
Issue number3
DOIs
Publication statusPublished - 1998 Jul
Externally publishedYes

Fingerprint

Breast Neoplasms
Neoplasms
Calcinosis
Lymph Nodes
Mammography
Carcinoma
Neoplasm Metastasis
Lymphatic Metastasis
Progesterone Receptors
Estrogen Receptors
Growth

Keywords

  • Apocrine carcinoma
  • Breast cancer
  • Prognosis

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Pharmacology (medical)

Cite this

Apocrine carcinoma of the breast : Clinicopathological analysis and histological subclassification of 12 cases. / Matsuo, Kaneyuki; Fukutomi, Takashi; Tsuda, Hitoshi; Kanai, Yae; Akashi-Tanaka, Sadako; Nanasawa, Takeshi.

In: Breast Cancer, Vol. 5, No. 3, 07.1998, p. 279-284.

Research output: Contribution to journalArticle

Matsuo, Kaneyuki ; Fukutomi, Takashi ; Tsuda, Hitoshi ; Kanai, Yae ; Akashi-Tanaka, Sadako ; Nanasawa, Takeshi. / Apocrine carcinoma of the breast : Clinicopathological analysis and histological subclassification of 12 cases. In: Breast Cancer. 1998 ; Vol. 5, No. 3. pp. 279-284.
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