ApoE gene and exceptional longevity

Insights from three independent cohorts

Nuria Garatachea, Enzo Emanuele, Miguel Calero, Noriyuki Fuku, Yasumichi Arai, Yukiko Abe, Haruka Murakami, Motohiko Miyachi, Thomas Yvert, Zoraida Verde, Ma Ascensión Zea, Letizia Venturini, Catalina Santiago, Alejandro Santos-Lozano, Gabriel Rodríguez-Romo, Giovanni Ricevuti, Nobuyoshi Hirose, Alberto Rábano, Alejandro Lucia

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

The ApoE gene is associated with the risk of Alzheimer or cardiovascular disease but its influence on exceptional longevity (EL) is uncertain. Our primary purpose was to determine, using a case-control design, if the ApoE gene is associated with EL. We compared ApoE allele/genotype frequencies among the following cohorts: cases (centenarians, most with 1. + major disease condition; n=163, 100-111. years) and healthy controls (n=1039, 20-85. years) from Spain; disease-free cases (centenarians; n=79, 100-104. years) and healthy controls (n=597, age 27-81. years) from Italy; and cases (centenarians and semi-supercentenarians, most with 1. + major disease condition; n=729, 100-116. years) and healthy controls (n=498, 23-59. years) from Japan. Our main findings were twofold. First, the ε4-allele was negatively associated with EL in the three cohorts, with the following odds ratio (OR) values (adjusted by sex) having been found: 0.55 (95% confidence interval (CI): 0.33, 0.94), P=0.030 (Spain); 0.41 (95%CI: 0.18, 0.99), P=0.05 (Italy); and 0.35 (95%CI: 0.26, 0.57), P<. 0.001 (Japan). Second, although no association was found in the Spanish cohort (OR=1.42 (95%CI: 0.89, 2.26), P=0.145), the ε2-allele was positively associated with EL in the Italian (OR=2.14 (95%CI: 1.18, 3.45), P=0.01) and Japanese subjects (OR=1.81 (95%CI: 1.25, 2.63), P=0.002). Notwithstanding the limitations of case-control designs, our data suggest that the ApoE might be a candidate to influence EL. The ε4-allele appears to decrease the likelihood of reaching EL among individuals of different ethnic/geographic origins. An additional, novel finding of our study was that the ε2-allele might favor EL, at least in the Italian and Japanese cohorts.

Original languageEnglish
Pages (from-to)16-23
Number of pages8
JournalExperimental Gerontology
Volume53
DOIs
Publication statusPublished - 2014

Fingerprint

Apolipoproteins E
Genes
Confidence Intervals
Alleles
Odds Ratio
Spain
Italy
Japan
Gene Frequency
Alzheimer Disease
Cardiovascular Diseases
Genotype

Keywords

  • ApoE
  • Case-control study
  • Centenarians
  • Genetics
  • Longevity

ASJC Scopus subject areas

  • Ageing
  • Biochemistry
  • Cell Biology
  • Endocrinology
  • Genetics
  • Molecular Biology
  • Medicine(all)

Cite this

ApoE gene and exceptional longevity : Insights from three independent cohorts. / Garatachea, Nuria; Emanuele, Enzo; Calero, Miguel; Fuku, Noriyuki; Arai, Yasumichi; Abe, Yukiko; Murakami, Haruka; Miyachi, Motohiko; Yvert, Thomas; Verde, Zoraida; Zea, Ma Ascensión; Venturini, Letizia; Santiago, Catalina; Santos-Lozano, Alejandro; Rodríguez-Romo, Gabriel; Ricevuti, Giovanni; Hirose, Nobuyoshi; Rábano, Alberto; Lucia, Alejandro.

In: Experimental Gerontology, Vol. 53, 2014, p. 16-23.

Research output: Contribution to journalArticle

Garatachea, N, Emanuele, E, Calero, M, Fuku, N, Arai, Y, Abe, Y, Murakami, H, Miyachi, M, Yvert, T, Verde, Z, Zea, MA, Venturini, L, Santiago, C, Santos-Lozano, A, Rodríguez-Romo, G, Ricevuti, G, Hirose, N, Rábano, A & Lucia, A 2014, 'ApoE gene and exceptional longevity: Insights from three independent cohorts', Experimental Gerontology, vol. 53, pp. 16-23. https://doi.org/10.1016/j.exger.2014.02.004
Garatachea, Nuria ; Emanuele, Enzo ; Calero, Miguel ; Fuku, Noriyuki ; Arai, Yasumichi ; Abe, Yukiko ; Murakami, Haruka ; Miyachi, Motohiko ; Yvert, Thomas ; Verde, Zoraida ; Zea, Ma Ascensión ; Venturini, Letizia ; Santiago, Catalina ; Santos-Lozano, Alejandro ; Rodríguez-Romo, Gabriel ; Ricevuti, Giovanni ; Hirose, Nobuyoshi ; Rábano, Alberto ; Lucia, Alejandro. / ApoE gene and exceptional longevity : Insights from three independent cohorts. In: Experimental Gerontology. 2014 ; Vol. 53. pp. 16-23.
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T2 - Insights from three independent cohorts

AU - Garatachea, Nuria

AU - Emanuele, Enzo

AU - Calero, Miguel

AU - Fuku, Noriyuki

AU - Arai, Yasumichi

AU - Abe, Yukiko

AU - Murakami, Haruka

AU - Miyachi, Motohiko

AU - Yvert, Thomas

AU - Verde, Zoraida

AU - Zea, Ma Ascensión

AU - Venturini, Letizia

AU - Santiago, Catalina

AU - Santos-Lozano, Alejandro

AU - Rodríguez-Romo, Gabriel

AU - Ricevuti, Giovanni

AU - Hirose, Nobuyoshi

AU - Rábano, Alberto

AU - Lucia, Alejandro

PY - 2014

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N2 - The ApoE gene is associated with the risk of Alzheimer or cardiovascular disease but its influence on exceptional longevity (EL) is uncertain. Our primary purpose was to determine, using a case-control design, if the ApoE gene is associated with EL. We compared ApoE allele/genotype frequencies among the following cohorts: cases (centenarians, most with 1. + major disease condition; n=163, 100-111. years) and healthy controls (n=1039, 20-85. years) from Spain; disease-free cases (centenarians; n=79, 100-104. years) and healthy controls (n=597, age 27-81. years) from Italy; and cases (centenarians and semi-supercentenarians, most with 1. + major disease condition; n=729, 100-116. years) and healthy controls (n=498, 23-59. years) from Japan. Our main findings were twofold. First, the ε4-allele was negatively associated with EL in the three cohorts, with the following odds ratio (OR) values (adjusted by sex) having been found: 0.55 (95% confidence interval (CI): 0.33, 0.94), P=0.030 (Spain); 0.41 (95%CI: 0.18, 0.99), P=0.05 (Italy); and 0.35 (95%CI: 0.26, 0.57), P<. 0.001 (Japan). Second, although no association was found in the Spanish cohort (OR=1.42 (95%CI: 0.89, 2.26), P=0.145), the ε2-allele was positively associated with EL in the Italian (OR=2.14 (95%CI: 1.18, 3.45), P=0.01) and Japanese subjects (OR=1.81 (95%CI: 1.25, 2.63), P=0.002). Notwithstanding the limitations of case-control designs, our data suggest that the ApoE might be a candidate to influence EL. The ε4-allele appears to decrease the likelihood of reaching EL among individuals of different ethnic/geographic origins. An additional, novel finding of our study was that the ε2-allele might favor EL, at least in the Italian and Japanese cohorts.

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