Apolipoprotein B-48: A unique marker of chylomicron metabolism

Katsuyuki Nakajima, Takeaki Nagamine, Masaki Q. Fujita, Masumi Ai, Akira Tanaka, Ernst Schaefer

Research output: Chapter in Book/Report/Conference proceedingChapter

23 Citations (Scopus)

Abstract

Apolipoprotein B-48 (apoB-48) is known to be the only specific marker of intestinal chylomicron particles. The amino acid sequence of apoB-48 represents 48% of the initial sequence of apoB-100. ApoB-48 is synthesized only by the intestine in humans, while apoB-100 is synthesized primarily by the liver. Therefore, apoB-48 is a most appropriate biomarker for cardiovascular and nutritional investigation of postprandial chylomicron metabolism. In this review article, we discussed the difference between the recent findings and Zilversmit's proposal of postprandial hyperlipidemia reported over 30 years ago. The characteristics and role of apoB-48 as an apolipoprotein in chylomicrons, especially as a marker of chylomicron remnant lipoproteins, are described. The need for appropriate analytical methods to measure apoB-48 is also discussed.

Original languageEnglish
Title of host publicationAdvances in Clinical Chemistry
PublisherAcademic Press Inc.
Pages117-177
Number of pages61
DOIs
Publication statusPublished - 2014

Publication series

NameAdvances in Clinical Chemistry
Volume64
ISSN (Print)0065-2423

Keywords

  • ApoB-100
  • ApoB-48
  • Chylomicron remnants
  • Postprandial lipoproteins
  • Remnant lipoprotein particles
  • Very low density lipoprotein remnants

ASJC Scopus subject areas

  • Chemistry(all)
  • Clinical Biochemistry

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    Nakajima, K., Nagamine, T., Fujita, M. Q., Ai, M., Tanaka, A., & Schaefer, E. (2014). Apolipoprotein B-48: A unique marker of chylomicron metabolism. In Advances in Clinical Chemistry (pp. 117-177). (Advances in Clinical Chemistry; Vol. 64). Academic Press Inc.. https://doi.org/10.1016/B978-0-12-800263-6.00003-3