Apolipoprotein B-48

A unique marker of chylomicron metabolism

Katsuyuki Nakajima, Takeaki Nagamine, Masaki Q Fujita, Masumi Ai, Akira Tanaka, Ernst Schaefer

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Apolipoprotein B-48 (apoB-48) is known to be the only specific marker of intestinal chylomicron particles. The amino acid sequence of apoB-48 represents 48% of the initial sequence of apoB-100. ApoB-48 is synthesized only by the intestine in humans, while apoB-100 is synthesized primarily by the liver. Therefore, apoB-48 is a most appropriate biomarker for cardiovascular and nutritional investigation of postprandial chylomicron metabolism. In this review article, we discussed the difference between the recent findings and Zilversmit's proposal of postprandial hyperlipidemia reported over 30 years ago. The characteristics and role of apoB-48 as an apolipoprotein in chylomicrons, especially as a marker of chylomicron remnant lipoproteins, are described. The need for appropriate analytical methods to measure apoB-48 is also discussed.

Original languageEnglish
Pages (from-to)117-177
Number of pages61
JournalAdvances in Clinical Chemistry
Volume64
DOIs
Publication statusPublished - 2014

Fingerprint

Apolipoprotein B-48
Chylomicrons
Metabolism
Apolipoprotein B-100
Chylomicron Remnants
Apolipoproteins
Biomarkers
Hyperlipidemias
Liver
Lipoproteins
Intestines
Amino Acid Sequence
Amino Acids

Keywords

  • ApoB-100
  • ApoB-48
  • Chylomicron remnants
  • Postprandial lipoproteins
  • Remnant lipoprotein particles
  • Very low density lipoprotein remnants

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Chemistry(all)
  • Medicine(all)

Cite this

Apolipoprotein B-48 : A unique marker of chylomicron metabolism. / Nakajima, Katsuyuki; Nagamine, Takeaki; Fujita, Masaki Q; Ai, Masumi; Tanaka, Akira; Schaefer, Ernst.

In: Advances in Clinical Chemistry, Vol. 64, 2014, p. 117-177.

Research output: Contribution to journalArticle

Nakajima, Katsuyuki ; Nagamine, Takeaki ; Fujita, Masaki Q ; Ai, Masumi ; Tanaka, Akira ; Schaefer, Ernst. / Apolipoprotein B-48 : A unique marker of chylomicron metabolism. In: Advances in Clinical Chemistry. 2014 ; Vol. 64. pp. 117-177.
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