Apolipoprotein E ε4 allele distribution in alcoholic dementia and in Alzheimer's disease in Japan

Taro Muramatsu, Susumu Higuchi, Hiroyuki Arai, Hidetada Sasaki, Koichi Yamada, Motoi Hayashida, John Q. Trojanowski

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23 Citations (Scopus)

Abstract

The apolipoprotein E ε4 allele has been associated with both familial and sporadic Alzheimer's disease (AD). Given its possible role in nerve repair and growth, it is plausible that apolipoprotein E may be a common denominator in the pathogenesis of several dementing diseases. Therefore, we investigated ε4 frequencies in demented and nondemented alcoholics, as well as in patients with sporadic AD and controls in Japan. No significant difference in allele frequencies was found between demented and nondemented alcoholics and controls, while a significant association was demonstrated between AD and the ε4 allele. These results support a specific role of ε4 in the pathogenesis of AD, rather than a more general role for ε4 in dementing illnesses.

Original languageEnglish
Pages (from-to)797-799
Number of pages3
JournalAnnals of Neurology
Volume36
Issue number5
DOIs
Publication statusPublished - 1994 Nov
Externally publishedYes

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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    Muramatsu, T., Higuchi, S., Arai, H., Sasaki, H., Yamada, K., Hayashida, M., & Trojanowski, J. Q. (1994). Apolipoprotein E ε4 allele distribution in alcoholic dementia and in Alzheimer's disease in Japan. Annals of Neurology, 36(5), 797-799. https://doi.org/10.1002/ana.410360519