Apolipoprotein E ε4 allele distribution in alcoholic dementia and in Alzheimer's disease in Japan

Taro Muramatsu, Susumu Higuchi, Hiroyuki Arai, Hidetada Sasaki, Koichi Yamada, Motoi Hayashida, John Q. Trojanowski

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

The apolipoprotein E ε4 allele has been associated with both familial and sporadic Alzheimer's disease (AD). Given its possible role in nerve repair and growth, it is plausible that apolipoprotein E may be a common denominator in the pathogenesis of several dementing diseases. Therefore, we investigated ε4 frequencies in demented and nondemented alcoholics, as well as in patients with sporadic AD and controls in Japan. No significant difference in allele frequencies was found between demented and nondemented alcoholics and controls, while a significant association was demonstrated between AD and the ε4 allele. These results support a specific role of ε4 in the pathogenesis of AD, rather than a more general role for ε4 in dementing illnesses.

Original languageEnglish
Pages (from-to)797-799
Number of pages3
JournalAnnals of Neurology
Volume36
Issue number5
DOIs
Publication statusPublished - 1994 Nov
Externally publishedYes

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Apolipoprotein E4
Dementia
Japan
Alzheimer Disease
Alleles
Alcoholics
Apolipoproteins E
Gene Frequency
Growth

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Muramatsu, T., Higuchi, S., Arai, H., Sasaki, H., Yamada, K., Hayashida, M., & Trojanowski, J. Q. (1994). Apolipoprotein E ε4 allele distribution in alcoholic dementia and in Alzheimer's disease in Japan. Annals of Neurology, 36(5), 797-799. https://doi.org/10.1002/ana.410360519

Apolipoprotein E ε4 allele distribution in alcoholic dementia and in Alzheimer's disease in Japan. / Muramatsu, Taro; Higuchi, Susumu; Arai, Hiroyuki; Sasaki, Hidetada; Yamada, Koichi; Hayashida, Motoi; Trojanowski, John Q.

In: Annals of Neurology, Vol. 36, No. 5, 11.1994, p. 797-799.

Research output: Contribution to journalArticle

Muramatsu, T, Higuchi, S, Arai, H, Sasaki, H, Yamada, K, Hayashida, M & Trojanowski, JQ 1994, 'Apolipoprotein E ε4 allele distribution in alcoholic dementia and in Alzheimer's disease in Japan', Annals of Neurology, vol. 36, no. 5, pp. 797-799. https://doi.org/10.1002/ana.410360519
Muramatsu, Taro ; Higuchi, Susumu ; Arai, Hiroyuki ; Sasaki, Hidetada ; Yamada, Koichi ; Hayashida, Motoi ; Trojanowski, John Q. / Apolipoprotein E ε4 allele distribution in alcoholic dementia and in Alzheimer's disease in Japan. In: Annals of Neurology. 1994 ; Vol. 36, No. 5. pp. 797-799.
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