Abstract
Objective: This study was designed to investigate in cognitively normal subjects the possible association between hypersensitive pupil dilation responses to the cholinergic antagonist tropicamide and the presence of the apolipoprotein E ξ4 (APOE4) allele, a well-defined genetic risk factor for Alzheimer's disease. Method: The authors measured tropicamide-induced changes in pupil area in 44 cognitively normal Japanese subjects with and without the APOE4 allele. Results: The subjects with the APOE4 allele had significantly greater increases in pupil area than the others. The significant correlation of changes in pupil area with age for the subjects with the APOE4 allele was lacking for those without this allele. Conclusions: The results suggest that a hypersensitive pupil dilation response to tropicamide is already present in cognitively normal individuals with the APOE4 allele. This association also suggests the potential involvement of APOE4 in the mechanism of pupil dilation.
| Original language | English |
|---|---|
| Pages (from-to) | 694-696 |
| Number of pages | 3 |
| Journal | American Journal of Psychiatry |
| Volume | 154 |
| Issue number | 5 |
| Publication status | Published - 1997 May |
| Externally published | Yes |
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ASJC Scopus subject areas
- Psychiatry and Mental health
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Apolipoprotein E ξ4 allele and pupillary response to tropicamide. / Higuchi, Susumu; Matsushita, Sachio; Hasegawa, Yoshio; Muramatsu, Taro; Arai, Hiroyuki; Hayashida, Motoi.
In: American Journal of Psychiatry, Vol. 154, No. 5, 05.1997, p. 694-696.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Apolipoprotein E ξ4 allele and pupillary response to tropicamide
AU - Higuchi, Susumu
AU - Matsushita, Sachio
AU - Hasegawa, Yoshio
AU - Muramatsu, Taro
AU - Arai, Hiroyuki
AU - Hayashida, Motoi
PY - 1997/5
Y1 - 1997/5
N2 - Objective: This study was designed to investigate in cognitively normal subjects the possible association between hypersensitive pupil dilation responses to the cholinergic antagonist tropicamide and the presence of the apolipoprotein E ξ4 (APOE4) allele, a well-defined genetic risk factor for Alzheimer's disease. Method: The authors measured tropicamide-induced changes in pupil area in 44 cognitively normal Japanese subjects with and without the APOE4 allele. Results: The subjects with the APOE4 allele had significantly greater increases in pupil area than the others. The significant correlation of changes in pupil area with age for the subjects with the APOE4 allele was lacking for those without this allele. Conclusions: The results suggest that a hypersensitive pupil dilation response to tropicamide is already present in cognitively normal individuals with the APOE4 allele. This association also suggests the potential involvement of APOE4 in the mechanism of pupil dilation.
AB - Objective: This study was designed to investigate in cognitively normal subjects the possible association between hypersensitive pupil dilation responses to the cholinergic antagonist tropicamide and the presence of the apolipoprotein E ξ4 (APOE4) allele, a well-defined genetic risk factor for Alzheimer's disease. Method: The authors measured tropicamide-induced changes in pupil area in 44 cognitively normal Japanese subjects with and without the APOE4 allele. Results: The subjects with the APOE4 allele had significantly greater increases in pupil area than the others. The significant correlation of changes in pupil area with age for the subjects with the APOE4 allele was lacking for those without this allele. Conclusions: The results suggest that a hypersensitive pupil dilation response to tropicamide is already present in cognitively normal individuals with the APOE4 allele. This association also suggests the potential involvement of APOE4 in the mechanism of pupil dilation.
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UR - http://www.scopus.com/inward/citedby.url?scp=0030611873&partnerID=8YFLogxK
M3 - Article
C2 - 9137131
AN - SCOPUS:0030611873
VL - 154
SP - 694
EP - 696
JO - American Journal of Psychiatry
JF - American Journal of Psychiatry
SN - 0002-953X
IS - 5
ER -