Apoptosis-inducing activity and antiproliferative effect of Paeoniflorigenone from moutan cortex

Ying Huang, Osamu Ohno, Kiyotake Suenaga, Kenji Miyamoto

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2 Citations (Scopus)

Abstract

Ninety samples from the extracts of plants from traditional Chinese medicines were screened for antitumor activity. Paeoniflorigenone (PFG) was isolated as an active ingredient from the root of moutan cortex, which showed the strongest activity. In addition, our data indicated that PFG was cytotoxic and induced apoptosis selectively in the cancer cell lines. These effects were cancelled by the addition of caspase inhibitor Z-VAD-FMK, suggesting that it was mediated by caspase-3 activation.

Original languageEnglish
Pages (from-to)1106-1113
Number of pages8
JournalBioscience, Biotechnology and Biochemistry
Volume81
Issue number6
DOIs
Publication statusPublished - 2017

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Keywords

  • Antiproliferative activity
  • Apoptosis
  • Caspase-3 activation
  • Paeonia suffruticosa Andr.
  • Paeoniflorigenone

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biotechnology
  • Biochemistry
  • Applied Microbiology and Biotechnology
  • Molecular Biology
  • Organic Chemistry

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