Apoptosis-inducing activity and antiproliferative effect of Paeoniflorigenone from moutan cortex

Ying Huang, Osamu Ohno, Kiyotake Suenaga, Kenji Miyamoto

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Ninety samples from the extracts of plants from traditional Chinese medicines were screened for antitumor activity. Paeoniflorigenone (PFG) was isolated as an active ingredient from the root of moutan cortex, which showed the strongest activity. In addition, our data indicated that PFG was cytotoxic and induced apoptosis selectively in the cancer cell lines. These effects were cancelled by the addition of caspase inhibitor Z-VAD-FMK, suggesting that it was mediated by caspase-3 activation.

Original languageEnglish
Pages (from-to)1106-1113
Number of pages8
JournalBioscience, Biotechnology and Biochemistry
Volume81
Issue number6
DOIs
Publication statusPublished - 2017

Fingerprint

Chinese Herbal Drugs
Apoptosis
Caspase Inhibitors
Chinese Traditional Medicine
Plant Extracts
Caspase 3
Medicine
Chemical activation
Cells
Cell Line
Neoplasms
paeoniflorigenone
moutan cortex
benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone

Keywords

  • Antiproliferative activity
  • Apoptosis
  • Caspase-3 activation
  • Paeonia suffruticosa Andr.
  • Paeoniflorigenone

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biotechnology
  • Biochemistry
  • Applied Microbiology and Biotechnology
  • Molecular Biology
  • Organic Chemistry

Cite this

Apoptosis-inducing activity and antiproliferative effect of Paeoniflorigenone from moutan cortex. / Huang, Ying; Ohno, Osamu; Suenaga, Kiyotake; Miyamoto, Kenji.

In: Bioscience, Biotechnology and Biochemistry, Vol. 81, No. 6, 2017, p. 1106-1113.

Research output: Contribution to journalArticle

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