Applicability of second-generation colon capsule endoscope to ulcerative colitis

A clinical feasibility study

Naoki Hosoe, Katsuyoshi Matsuoka, Makoto Naganuma, Yosuke Ida, Yuka Ishibashi, Kayoko Hukuhara, Kazuaki Yoneno, Shingo Usui, Kazuhiro Kashiwagi, Tadakazu Hisamatsu, Nagamu Inoue, Takanori Kanai, Hiroyuki Imaeda, Haruhiko Ogata, Toshifumi Hibi

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

Background and Aim: Colon capsule endoscopy has already been used for colon visualization and detection of polyps but its applicability to inflammatory bowel disease is still unconfirmed. The aim of this study was to assess the feasibility of evaluating the severity of mucosal inflammation in patients with ulcerative colitis (UC) using a second-generation colon capsule endoscope (CCE-2). Methods: Forty patients with histological confirmed diagnosis of UC were enrolled. Low-volume (2L) polyethylene glycol solution with prokinetics (mosapride citrate and metoclopramide) regimen was used for the bowel preparation. In Phase 1, consisting of 10 patients, to confirm appropriate CCE-2 bowel preparation for UC. In Phase 2, consisting of 30 patients, CCE-2 was performed with a fixed bowel preparation regimen. CCE-2 findings were recorded for 8h starting from capsule ingestion and conventional colonoscopy was subsequently performed on the same day. CCE-2 procedure completion rate and the colon cleansing level with a 4-point grading scale (poor, fair, good, and excellent) were evaluated in Phase 2. Correlations between Matts endoscopic scores as judged by CCE-2 and conventional colonoscopy were calculated. Results: CCE-2 procedure was completed within 8h in 69% of the patients. The proportion of patients with good or excellent cleansing level was below 50%. However, Matts endoscopic scores determined by CCE-2 showed a strong correlation with scores obtained by conventional colonoscopy (average ρ=0.797). Conclusions: Although modifications in bowel preparation are needed, CCE-2 might be feasible for assessing the severity of mucosal inflammation in patients with UC.

Original languageEnglish
Pages (from-to)1174-1179
Number of pages6
JournalJournal of Gastroenterology and Hepatology (Australia)
Volume28
Issue number7
DOIs
Publication statusPublished - 2013

Fingerprint

Capsule Endoscopes
Feasibility Studies
Ulcerative Colitis
Colon
Colonoscopy
Inflammation
Capsule Endoscopy
Metoclopramide
Polyps
Clinical Studies
Inflammatory Bowel Diseases
Capsules
Eating

Keywords

  • Colon capsule endoscopy
  • Colonoscopy
  • Polyethylene glycol
  • Ulcerative colitis

ASJC Scopus subject areas

  • Gastroenterology
  • Hepatology

Cite this

Applicability of second-generation colon capsule endoscope to ulcerative colitis : A clinical feasibility study. / Hosoe, Naoki; Matsuoka, Katsuyoshi; Naganuma, Makoto; Ida, Yosuke; Ishibashi, Yuka; Hukuhara, Kayoko; Yoneno, Kazuaki; Usui, Shingo; Kashiwagi, Kazuhiro; Hisamatsu, Tadakazu; Inoue, Nagamu; Kanai, Takanori; Imaeda, Hiroyuki; Ogata, Haruhiko; Hibi, Toshifumi.

In: Journal of Gastroenterology and Hepatology (Australia), Vol. 28, No. 7, 2013, p. 1174-1179.

Research output: Contribution to journalArticle

Hosoe, Naoki ; Matsuoka, Katsuyoshi ; Naganuma, Makoto ; Ida, Yosuke ; Ishibashi, Yuka ; Hukuhara, Kayoko ; Yoneno, Kazuaki ; Usui, Shingo ; Kashiwagi, Kazuhiro ; Hisamatsu, Tadakazu ; Inoue, Nagamu ; Kanai, Takanori ; Imaeda, Hiroyuki ; Ogata, Haruhiko ; Hibi, Toshifumi. / Applicability of second-generation colon capsule endoscope to ulcerative colitis : A clinical feasibility study. In: Journal of Gastroenterology and Hepatology (Australia). 2013 ; Vol. 28, No. 7. pp. 1174-1179.
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T1 - Applicability of second-generation colon capsule endoscope to ulcerative colitis

T2 - A clinical feasibility study

AU - Hosoe, Naoki

AU - Matsuoka, Katsuyoshi

AU - Naganuma, Makoto

AU - Ida, Yosuke

AU - Ishibashi, Yuka

AU - Hukuhara, Kayoko

AU - Yoneno, Kazuaki

AU - Usui, Shingo

AU - Kashiwagi, Kazuhiro

AU - Hisamatsu, Tadakazu

AU - Inoue, Nagamu

AU - Kanai, Takanori

AU - Imaeda, Hiroyuki

AU - Ogata, Haruhiko

AU - Hibi, Toshifumi

PY - 2013

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N2 - Background and Aim: Colon capsule endoscopy has already been used for colon visualization and detection of polyps but its applicability to inflammatory bowel disease is still unconfirmed. The aim of this study was to assess the feasibility of evaluating the severity of mucosal inflammation in patients with ulcerative colitis (UC) using a second-generation colon capsule endoscope (CCE-2). Methods: Forty patients with histological confirmed diagnosis of UC were enrolled. Low-volume (2L) polyethylene glycol solution with prokinetics (mosapride citrate and metoclopramide) regimen was used for the bowel preparation. In Phase 1, consisting of 10 patients, to confirm appropriate CCE-2 bowel preparation for UC. In Phase 2, consisting of 30 patients, CCE-2 was performed with a fixed bowel preparation regimen. CCE-2 findings were recorded for 8h starting from capsule ingestion and conventional colonoscopy was subsequently performed on the same day. CCE-2 procedure completion rate and the colon cleansing level with a 4-point grading scale (poor, fair, good, and excellent) were evaluated in Phase 2. Correlations between Matts endoscopic scores as judged by CCE-2 and conventional colonoscopy were calculated. Results: CCE-2 procedure was completed within 8h in 69% of the patients. The proportion of patients with good or excellent cleansing level was below 50%. However, Matts endoscopic scores determined by CCE-2 showed a strong correlation with scores obtained by conventional colonoscopy (average ρ=0.797). Conclusions: Although modifications in bowel preparation are needed, CCE-2 might be feasible for assessing the severity of mucosal inflammation in patients with UC.

AB - Background and Aim: Colon capsule endoscopy has already been used for colon visualization and detection of polyps but its applicability to inflammatory bowel disease is still unconfirmed. The aim of this study was to assess the feasibility of evaluating the severity of mucosal inflammation in patients with ulcerative colitis (UC) using a second-generation colon capsule endoscope (CCE-2). Methods: Forty patients with histological confirmed diagnosis of UC were enrolled. Low-volume (2L) polyethylene glycol solution with prokinetics (mosapride citrate and metoclopramide) regimen was used for the bowel preparation. In Phase 1, consisting of 10 patients, to confirm appropriate CCE-2 bowel preparation for UC. In Phase 2, consisting of 30 patients, CCE-2 was performed with a fixed bowel preparation regimen. CCE-2 findings were recorded for 8h starting from capsule ingestion and conventional colonoscopy was subsequently performed on the same day. CCE-2 procedure completion rate and the colon cleansing level with a 4-point grading scale (poor, fair, good, and excellent) were evaluated in Phase 2. Correlations between Matts endoscopic scores as judged by CCE-2 and conventional colonoscopy were calculated. Results: CCE-2 procedure was completed within 8h in 69% of the patients. The proportion of patients with good or excellent cleansing level was below 50%. However, Matts endoscopic scores determined by CCE-2 showed a strong correlation with scores obtained by conventional colonoscopy (average ρ=0.797). Conclusions: Although modifications in bowel preparation are needed, CCE-2 might be feasible for assessing the severity of mucosal inflammation in patients with UC.

KW - Colon capsule endoscopy

KW - Colonoscopy

KW - Polyethylene glycol

KW - Ulcerative colitis

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