Application of efficient glycosylation of 2,6-anhydro-2-thio sugar to the total synthesis of erythromycin A

Kazunobu Toshima, Satsuki Mukaiyama, Takehito Yoshida, Tetsuro Tamai, Kuniaki Tatsuta

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

The total synthesis of erythromycin A (I) from (9S)-9-dihydroerythronolide A (2) was achieved efficiently by the highly stereoselective and powerful glycosylation of 2,6-anhydro-2-thio sugar 9 as a key step.

Original languageEnglish
Pages (from-to)6155-6158
Number of pages4
JournalTetrahedron Letters
Volume32
Issue number43
DOIs
Publication statusPublished - 1991 Oct 21

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Keywords

  • (9S)-9-Dihydrocrythronolide A
  • 2,6-Anhydro-2-thio-sugar
  • Erythromycin A.
  • Glycosylation

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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