Application of FDG-PET in cervical cancer and endometrial cancer: Utility and future prospects

Yuya Nogami, Miho Iida, Kouji Banno, Iori Kisu, Masataka Adachi, Kanako Nakamura, Kiyoko Umene, Kenta Masuda, Eiichiro Tominaga, Kyoko Tanaka, Daisuke Aoki

Research output: Contribution to journalReview article

23 Citations (Scopus)

Abstract

Positron-emission tomography (PET), a diagnostic imaging technique using an agent labeled with a positron-emitting radionuclide, may facilitate improved diagnosis and treatment in gynecological fields. A combined PET/computerized tomography (CT) scan can identify the precise anatomical location of a lesion based on accumulation of 18F-fluoro-D-glucose (FDG). FDG-PET and PET/CT have been used for detecting metastatic lesions and predicting prognosis in uterine cancer. PET has higher reliability in diagnosing lymph node metastases of uterine cancer than CT or MRI, and is considered most useful among non-invasive diagnostic imaging methods. Accumulation of FDG in lesions is indicative of a poor prognosis. Due to its limited spatial resolution, PET is not suitable has lower utility for detecting small lesions, and is not suitable for early-stage screening, and diagnosing primary lesions. Further improvements in diagnostic technology, including PET/MRI, investigation of new positron tracers, and analysis of data from various combinations of tracers are likely to make PET particularly useful for diagnosis and therapeutic strategy planning.

Original languageEnglish
Pages (from-to)585-592
Number of pages8
JournalAnticancer research
Volume34
Issue number2
Publication statusPublished - 2014 Feb 1

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Keywords

  • Cervical cancer
  • Endometrial cancer
  • FDG-PET
  • Review
  • SUV
  • Sensitivity
  • Specificity

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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