Application of high pressure induced by water-freezing to the direct catalytic asymmetric three-component List-Barbas-Mannich reaction

Yujiro Hayashi; Wataru Tsuboi; Mitsuru Shoji; Noriyuki Suzuki

doi:10.1021/ja0372513

Application of high pressure induced by water-freezing to the direct catalytic asymmetric three-component List-Barbas-Mannich reaction

Yujiro Hayashi, Wataru Tsuboi, Mitsuru Shoji, Noriyuki Suzuki

School of Pharmaceutical Sciences

Research output: Contribution to journal › Article › peer-review

140 Citations (Scopus)

Abstract

High pressure induced by water-freezing has been successfully applied to the direct catalytic asymmetric-three component List-Barbas-Mannich reaction, in which higher yield and better enantioselectivity can be realized than those from the reaction at room temperature under 0.1 MPa.

Original language	English
Pages (from-to)	11208-11209
Number of pages	2
Journal	Journal of the American Chemical Society
Volume	125
Issue number	37
DOIs	https://doi.org/10.1021/ja0372513
Publication status	Published - 2003 Sept 17

ASJC Scopus subject areas

Catalysis
Chemistry(all)
Biochemistry
Colloid and Surface Chemistry

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10.1021/ja0372513

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title = "Application of high pressure induced by water-freezing to the direct catalytic asymmetric three-component List-Barbas-Mannich reaction",

abstract = "High pressure induced by water-freezing has been successfully applied to the direct catalytic asymmetric-three component List-Barbas-Mannich reaction, in which higher yield and better enantioselectivity can be realized than those from the reaction at room temperature under 0.1 MPa.",

author = "Yujiro Hayashi and Wataru Tsuboi and Mitsuru Shoji and Noriyuki Suzuki",

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AU - Hayashi, Yujiro

AU - Tsuboi, Wataru

AU - Shoji, Mitsuru

AU - Suzuki, Noriyuki

PY - 2003/9/17

Y1 - 2003/9/17

N2 - High pressure induced by water-freezing has been successfully applied to the direct catalytic asymmetric-three component List-Barbas-Mannich reaction, in which higher yield and better enantioselectivity can be realized than those from the reaction at room temperature under 0.1 MPa.

AB - High pressure induced by water-freezing has been successfully applied to the direct catalytic asymmetric-three component List-Barbas-Mannich reaction, in which higher yield and better enantioselectivity can be realized than those from the reaction at room temperature under 0.1 MPa.

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Application of high pressure induced by water-freezing to the direct catalytic asymmetric three-component List-Barbas-Mannich reaction

Abstract

ASJC Scopus subject areas

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