Application of high pressure induced by water-freezing to the direct catalytic asymmetric three-component List-Barbas-Mannich reaction

Yujiro Hayashi, Wataru Tsuboi, Mitsuru Shoji, Noriyuki Suzuki

Research output: Contribution to journalArticle

131 Citations (Scopus)

Abstract

High pressure induced by water-freezing has been successfully applied to the direct catalytic asymmetric-three component List-Barbas-Mannich reaction, in which higher yield and better enantioselectivity can be realized than those from the reaction at room temperature under 0.1 MPa.

Original languageEnglish
Pages (from-to)11208-11209
Number of pages2
JournalJournal of the American Chemical Society
Volume125
Issue number37
DOIs
Publication statusPublished - 2003 Sep 17
Externally publishedYes

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Enantioselectivity
Freezing
Pressure
Temperature
Water

ASJC Scopus subject areas

  • Chemistry(all)

Cite this

Application of high pressure induced by water-freezing to the direct catalytic asymmetric three-component List-Barbas-Mannich reaction. / Hayashi, Yujiro; Tsuboi, Wataru; Shoji, Mitsuru; Suzuki, Noriyuki.

In: Journal of the American Chemical Society, Vol. 125, No. 37, 17.09.2003, p. 11208-11209.

Research output: Contribution to journalArticle

Hayashi, Yujiro ; Tsuboi, Wataru ; Shoji, Mitsuru ; Suzuki, Noriyuki. / Application of high pressure induced by water-freezing to the direct catalytic asymmetric three-component List-Barbas-Mannich reaction. In: Journal of the American Chemical Society. 2003 ; Vol. 125, No. 37. pp. 11208-11209.
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