Application of high pressure, induced by water freezing, to the direct asymmetric aldol reaction

Yujiro Hayashi, Wataru Tsuboi, Mitsuru Shoji, Noriyuki Suzuki

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55 Citations (Scopus)


High pressure, induced by water freezing, has been successfully applied to the direct catalytic asymmetric aldol reaction, in which higher yield and better enantioselectivity can be realized than in the reaction at room temperature under 0.1MPa.

Original languageEnglish
Pages (from-to)4353-4356
Number of pages4
JournalTetrahedron Letters
Issue number22
Publication statusPublished - 2004 May 24



  • Asymmetric reaction
  • Direct aldol reaction
  • High pressure
  • Organocatalyst
  • Proline

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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