Application of intramolecular Dötz reaction to the synthesis of ansa-compounds: concise synthesis of arnebinol

Masahito Watanabe, Kyosuke Tanaka, Yoko Saikawa, Masaya Nakata

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Fischer carbene complexes having long alkynyloxy chains regioselectively produced oxametacyclophanes via the intramolecular Dötz reaction. The utility of this reaction was demonstrated in the synthesis of arnebinol, an ansa-type terpenoid, from geranyl acetate in six steps.

Original languageEnglish
Pages (from-to)203-206
Number of pages4
JournalTetrahedron Letters
Volume48
Issue number2
DOIs
Publication statusPublished - 2007 Jan 8

Keywords

  • Ansa-compound
  • Arnebinol
  • Dötz reaction
  • Fischer carbene complex

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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