Application of liquid particle extraction to the purification of glycyrrhizin

H. Nishizawa, S. Okimura, Y. Watanabe, Y. Abe

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Glycyrrhizin on the market (about 90% in purity) contains two major impurities which are difficult to remove by recrystallization. Purification of a commercial sample was carried out by a dual-flow countercurrent extraction method, liquid particle extraction, which was recently introduced. Starting from 72.6 mg of commercial glycyrrhizin, it was purified to a purity of 99.7% with a recovery of 53.9% (35.3 mg).

Original languageEnglish
Pages (from-to)969-971
Number of pages3
JournalChemical and Pharmaceutical Bulletin
Volume39
Issue number4
Publication statusPublished - 1991

Fingerprint

Glycyrrhizic Acid
Purification
Liquids
Crystallization
Impurities
Recovery

ASJC Scopus subject areas

  • Chemistry(all)
  • Organic Chemistry
  • Drug Discovery
  • Pharmacology

Cite this

Nishizawa, H., Okimura, S., Watanabe, Y., & Abe, Y. (1991). Application of liquid particle extraction to the purification of glycyrrhizin. Chemical and Pharmaceutical Bulletin, 39(4), 969-971.

Application of liquid particle extraction to the purification of glycyrrhizin. / Nishizawa, H.; Okimura, S.; Watanabe, Y.; Abe, Y.

In: Chemical and Pharmaceutical Bulletin, Vol. 39, No. 4, 1991, p. 969-971.

Research output: Contribution to journalArticle

Nishizawa, H, Okimura, S, Watanabe, Y & Abe, Y 1991, 'Application of liquid particle extraction to the purification of glycyrrhizin', Chemical and Pharmaceutical Bulletin, vol. 39, no. 4, pp. 969-971.
Nishizawa, H. ; Okimura, S. ; Watanabe, Y. ; Abe, Y. / Application of liquid particle extraction to the purification of glycyrrhizin. In: Chemical and Pharmaceutical Bulletin. 1991 ; Vol. 39, No. 4. pp. 969-971.
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