TY - JOUR
T1 - Application of low-intensity ultraviolet irradiation to the treatment for pharmacological vasoconstriction via a percutaneous transluminal approach.
AU - Nakai, K.
AU - Morimoto, Y.
AU - Arai, T.
AU - Ito, H.
AU - Kominami, M.
AU - Matsuo, H.
AU - Kikuchi, M.
N1 - Copyright:
This record is sourced from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
PY - 1999
Y1 - 1999
N2 - We applied low-power ultraviolet (UV) laser irradiation via a thin flexible optical fiber to an in vivo model of vasospasm using an intravascular transluminal approach. The surgically exposed left femoral arteries of a rabbit were constricted by norepinephrine. A quartz fiber of 400 microm in diameter was introduced into the artery via the right common carotid artery through a 2.5F catheter. The femoral artery lumen was then irradiated with a helium-cadmium laser (wavelength 325 nm, output power 8 mW) through the fiber for 30 s. The UV irradiation increased the mean luminal diameter by 85% in comparison to the precontracted state, while the increase was only 45% in a sham operation. A histopathologic examination revealed no thermal damage and an intact internal elastic lamina. These results suggest that intravascular transluminal irradiation with a low-power UV laser may thus have potentially clinical applications to reverse acute arterial vasospasm.
AB - We applied low-power ultraviolet (UV) laser irradiation via a thin flexible optical fiber to an in vivo model of vasospasm using an intravascular transluminal approach. The surgically exposed left femoral arteries of a rabbit were constricted by norepinephrine. A quartz fiber of 400 microm in diameter was introduced into the artery via the right common carotid artery through a 2.5F catheter. The femoral artery lumen was then irradiated with a helium-cadmium laser (wavelength 325 nm, output power 8 mW) through the fiber for 30 s. The UV irradiation increased the mean luminal diameter by 85% in comparison to the precontracted state, while the increase was only 45% in a sham operation. A histopathologic examination revealed no thermal damage and an intact internal elastic lamina. These results suggest that intravascular transluminal irradiation with a low-power UV laser may thus have potentially clinical applications to reverse acute arterial vasospasm.
UR - http://www.scopus.com/inward/record.url?scp=0033252605&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0033252605&partnerID=8YFLogxK
M3 - Article
C2 - 10612563
AN - SCOPUS:0033252605
VL - 9
SP - 241
EP - 248
JO - Frontiers of medical and biological engineering : the international journal of the Japan Society of Medical Electronics and Biological Engineering
JF - Frontiers of medical and biological engineering : the international journal of the Japan Society of Medical Electronics and Biological Engineering
SN - 0921-3775
IS - 3
ER -