Application of polymer particles on SPR sensor about control of telomerase function

Ryuji Hara, Kazunobu Toshima, Haruma Kawaguchi

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The interaction of G-quadruplex (G4)-DNA with telomerase inhibitors was investigated using SPR sensor. SPR signal was enhanced with polymer particle on which inhibitor was immobilized. The relation among molecular structure of inhibitors, inhibition activity and the effect of polymer particles was discussed. And we also evaluated effect of flow rate and amount of inhibitor which was immobilized on polymer particle. The results suggested polymer particle led to enhancement of SPR signal of interaction between G4-DNA and telomerase inhibitors, and the affinity of inhibitors immobilized on particle was unchanged with respect to structures of DNA.

Original languageEnglish
Title of host publicationPolymer Preprints, Japan
Pages4983-4984
Number of pages2
Volume55
Edition2
Publication statusPublished - 2006
Event55th Society of Polymer Science Japan Symposium on Macromolecules - Toyama, Japan
Duration: 2006 Sep 202006 Sep 22

Other

Other55th Society of Polymer Science Japan Symposium on Macromolecules
CountryJapan
CityToyama
Period06/9/2006/9/22

Fingerprint

DNA
Sensors
Polymers
Molecular structure
Flow rate

Keywords

  • Polymer particle
  • SPR (Surface Plasmon Resonance)
  • Telomerase inhibitor
  • Telomere

ASJC Scopus subject areas

  • Engineering(all)

Cite this

Hara, R., Toshima, K., & Kawaguchi, H. (2006). Application of polymer particles on SPR sensor about control of telomerase function. In Polymer Preprints, Japan (2 ed., Vol. 55, pp. 4983-4984)

Application of polymer particles on SPR sensor about control of telomerase function. / Hara, Ryuji; Toshima, Kazunobu; Kawaguchi, Haruma.

Polymer Preprints, Japan. Vol. 55 2. ed. 2006. p. 4983-4984.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Hara, R, Toshima, K & Kawaguchi, H 2006, Application of polymer particles on SPR sensor about control of telomerase function. in Polymer Preprints, Japan. 2 edn, vol. 55, pp. 4983-4984, 55th Society of Polymer Science Japan Symposium on Macromolecules, Toyama, Japan, 06/9/20.
Hara R, Toshima K, Kawaguchi H. Application of polymer particles on SPR sensor about control of telomerase function. In Polymer Preprints, Japan. 2 ed. Vol. 55. 2006. p. 4983-4984
Hara, Ryuji ; Toshima, Kazunobu ; Kawaguchi, Haruma. / Application of polymer particles on SPR sensor about control of telomerase function. Polymer Preprints, Japan. Vol. 55 2. ed. 2006. pp. 4983-4984
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