Application of polymer particles on SPR sensor about control of telomerase function

Ryuji Hara, Kazunobu Toshima, Haruma Kawaguchi

Research output: Contribution to conferencePaper

Abstract

The interaction of G-quadruplex (G4)-DNA with telomerase inhibitors was investigated using SPR sensor. SPR signal was enhanced with polymer particle on which inhibitor was immobilized. The relation among molecular structure of inhibitors, inhibition activity and the effect of polymer particles was discussed. And we also evaluated effect of flow rate and amount of inhibitor which was immobilized on polymer particle. The results suggested polymer particle led to enhancement of SPR signal of interaction between G4-DNA and telomerase inhibitors, and the affinity of inhibitors immobilized on particle was unchanged with respect to structures of DNA.

Original languageEnglish
Pages4983-4984
Number of pages2
Publication statusPublished - 2006 Dec 1
Event55th Society of Polymer Science Japan Symposium on Macromolecules - Toyama, Japan
Duration: 2006 Sep 202006 Sep 22

Other

Other55th Society of Polymer Science Japan Symposium on Macromolecules
CountryJapan
CityToyama
Period06/9/2006/9/22

Keywords

  • Polymer particle
  • SPR (Surface Plasmon Resonance)
  • Telomerase inhibitor
  • Telomere

ASJC Scopus subject areas

  • Engineering(all)

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  • Cite this

    Hara, R., Toshima, K., & Kawaguchi, H. (2006). Application of polymer particles on SPR sensor about control of telomerase function. 4983-4984. Paper presented at 55th Society of Polymer Science Japan Symposium on Macromolecules, Toyama, Japan.