Aquaporin 1 water channel is overexpressed in the plasma membranes of pancreatic ducts in patients with autoimmune pancreatitis

Shigeru B.H. Ko, Nobumasa Mizuno, Yasushi Yatabe, Toshiyuki Yoshikawa, Hiroshi Ishiguro, Akiko Yamamoto, Sakiko Azuma, Satoru Naruse, Kenji Yamao, Shmuel Muallem, Hidemi Goto

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14 Citations (Scopus)

Abstract

Chronic pancreatitis with all kinds of etiologies is characterized by pancreatic exocrine dysfunction especially impaired fluid secretion from pancreatic ducts. However, the molecular mechanism of this impaired fluid secretion in chronic pancreatitis is largely unknown. Aquaporin water channels are intrinsic membrane proteins expressed most of the cell types which have high osmotic water permeability. Among them aquaporin 1 (AQP1) is a predominant water channel expressed in the plasma membranes of human pancreatic ducts. Exocrine function test revealed that fluid secretion was severely impaired in AIP. immunohistochemical analysis revealed that AQP1 is localized mainly in the apical and lateral membranes of small pancreatic ducts in control subjects. AQP1 expression was significantly increased in plasma membranes of pancreatic ducts in AIP. Upregulation of AQP1 expression seen in pancreatic ducts of patient with AIP may be caused by the reduced fluid secretion from the pancreas as compensation. Further study would be required to elucidate the precise molecular mechanism for the role of AQP1 in pancreatic fluid secretion from the pancreas in diseases characterized by the impaired ductal fluid secretion such as cystic fibrosis.

Original languageEnglish
Pages (from-to)318-321
Number of pages4
JournalJournal of Medical Investigation
Volume56
Issue numberSUPPL. 1
DOIs
Publication statusPublished - 2009 Dec 1

Keywords

  • Aquaporin1
  • Autoimmune pancreatitis
  • Immunolocalization
  • Pancreatic exocrine function
  • Secretin test

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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    Ko, S. B. H., Mizuno, N., Yatabe, Y., Yoshikawa, T., Ishiguro, H., Yamamoto, A., Azuma, S., Naruse, S., Yamao, K., Muallem, S., & Goto, H. (2009). Aquaporin 1 water channel is overexpressed in the plasma membranes of pancreatic ducts in patients with autoimmune pancreatitis. Journal of Medical Investigation, 56(SUPPL. 1), 318-321. https://doi.org/10.2152/jmi.56.318