Aquaporins and disease: Lessons from mice to humans

Landon S. King, Masato Yasui

Research output: Contribution to journalArticle

63 Citations (Scopus)

Abstract

Recent discovery of a family of water-specific membrane channel proteins, the aquaporins, has provided new insights into the molecular basis of membrane water permeability. Eleven mammalian aquaporins have been identified to date, with homolog present across the spectrum of life, including bacteria, yeast and plants. The distribution of the mammalian aquaporins predicts their participation in a range of pathophysiological events. Empirical evidence of a physiological role for aquaporins is emerging from studies in both mice and humans, and suggests that aquaporins are likely to play significant roles in human pathophysiology.

Original languageEnglish
Pages (from-to)355-360
Number of pages6
JournalTrends in Endocrinology and Metabolism
Volume13
Issue number8
DOIs
Publication statusPublished - 2002 Oct
Externally publishedYes

Fingerprint

Aquaporins
Water
Ion Channels
Permeability
Membrane Proteins
Yeasts
Bacteria
Membranes

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

Aquaporins and disease : Lessons from mice to humans. / King, Landon S.; Yasui, Masato.

In: Trends in Endocrinology and Metabolism, Vol. 13, No. 8, 10.2002, p. 355-360.

Research output: Contribution to journalArticle

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