Arterial visualization by contrast-enhanced moving-table MR angiography: Crossover comparison of 0.1 and 0.2 mmol/kg doses of meglumine gadopentetate in normal volunteers

Hiromitsu Hayashi, Yuji Yuasa, Yasuo Amano, Akihiro Tanimoto, Yoko Saito, Kunihiro Yoshioka, Miho Kita, Tatsuo Kumazaki, Kyoichi Hiramatsu

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Purpose: To determine the appropriate dose of contrast medium for moving-table MR angiography (MT-MRA) from the abdominal aorta to the ankle by comparing visualization with different doses of meglumine gadopentetate (Gd-DTPA) administered in crossover fashion to normal volunteers. Materials and Methods: Twelve healthy adults underwent imaging after crossover administration of 0.1 and 0.2 mmol/kg of Gd-DTPA in random order. Continuous MT-MRA was performed with a fast 3D spoiled gradient echo sequence without parallel imaging technique. Visualization was evaluated in a total of 252 arteries by three blinded readers who independently rated arterial visualization using a 5-grade scale. Signal Intensity was determined and the blood concentration of Gd-DTPA was estimated. Results: Arterial visualization in the lower leg region was significantly better with a dose of 0.2 mmol/kg than with 0.1 mmol/kg (P < 0.001). For all regions assessed the estimated blood Gd-DTPA level was significantly higher with 0.2 mmol/kg than with 0.1 mmol/kg (abdominal aorta, P = 0.030; superficial femoral artery, P < 0.001; posterior tibial artery, P = 0.039). The vascular signal enhancement ratio and artery-to-muscle signal ratio were significantly higher in the upper leg and lower leg regions at 0.2 mmol/kg. Conclusion: With continuous MT-MRA imaging from the abdomen to the ankle in normal volunteers, better arterial visualization and superior contrast were achieved with 0.2 mmol/kg of Gd-DTPA.

Original languageEnglish
Pages (from-to)783-790
Number of pages8
JournalJournal of Magnetic Resonance Imaging
Volume28
Issue number3
DOIs
Publication statusPublished - 2008 Sep

Fingerprint

Meglumine
Gadolinium DTPA
Healthy Volunteers
Angiography
Leg
Abdominal Aorta
Ankle
Arteries
Tibial Arteries
Femoral Artery
Abdomen
Contrast Media
Blood Vessels
Muscles

Keywords

  • Comparative studies
  • Contrast medium
  • Cross-over administration
  • Meglumine gadopentetate
  • Moving-table MR angiography
  • MR angiography

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

Arterial visualization by contrast-enhanced moving-table MR angiography : Crossover comparison of 0.1 and 0.2 mmol/kg doses of meglumine gadopentetate in normal volunteers. / Hayashi, Hiromitsu; Yuasa, Yuji; Amano, Yasuo; Tanimoto, Akihiro; Saito, Yoko; Yoshioka, Kunihiro; Kita, Miho; Kumazaki, Tatsuo; Hiramatsu, Kyoichi.

In: Journal of Magnetic Resonance Imaging, Vol. 28, No. 3, 09.2008, p. 783-790.

Research output: Contribution to journalArticle

Hayashi, Hiromitsu ; Yuasa, Yuji ; Amano, Yasuo ; Tanimoto, Akihiro ; Saito, Yoko ; Yoshioka, Kunihiro ; Kita, Miho ; Kumazaki, Tatsuo ; Hiramatsu, Kyoichi. / Arterial visualization by contrast-enhanced moving-table MR angiography : Crossover comparison of 0.1 and 0.2 mmol/kg doses of meglumine gadopentetate in normal volunteers. In: Journal of Magnetic Resonance Imaging. 2008 ; Vol. 28, No. 3. pp. 783-790.
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abstract = "Purpose: To determine the appropriate dose of contrast medium for moving-table MR angiography (MT-MRA) from the abdominal aorta to the ankle by comparing visualization with different doses of meglumine gadopentetate (Gd-DTPA) administered in crossover fashion to normal volunteers. Materials and Methods: Twelve healthy adults underwent imaging after crossover administration of 0.1 and 0.2 mmol/kg of Gd-DTPA in random order. Continuous MT-MRA was performed with a fast 3D spoiled gradient echo sequence without parallel imaging technique. Visualization was evaluated in a total of 252 arteries by three blinded readers who independently rated arterial visualization using a 5-grade scale. Signal Intensity was determined and the blood concentration of Gd-DTPA was estimated. Results: Arterial visualization in the lower leg region was significantly better with a dose of 0.2 mmol/kg than with 0.1 mmol/kg (P < 0.001). For all regions assessed the estimated blood Gd-DTPA level was significantly higher with 0.2 mmol/kg than with 0.1 mmol/kg (abdominal aorta, P = 0.030; superficial femoral artery, P < 0.001; posterior tibial artery, P = 0.039). The vascular signal enhancement ratio and artery-to-muscle signal ratio were significantly higher in the upper leg and lower leg regions at 0.2 mmol/kg. Conclusion: With continuous MT-MRA imaging from the abdomen to the ankle in normal volunteers, better arterial visualization and superior contrast were achieved with 0.2 mmol/kg of Gd-DTPA.",
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author = "Hiromitsu Hayashi and Yuji Yuasa and Yasuo Amano and Akihiro Tanimoto and Yoko Saito and Kunihiro Yoshioka and Miho Kita and Tatsuo Kumazaki and Kyoichi Hiramatsu",
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T1 - Arterial visualization by contrast-enhanced moving-table MR angiography

T2 - Crossover comparison of 0.1 and 0.2 mmol/kg doses of meglumine gadopentetate in normal volunteers

AU - Hayashi, Hiromitsu

AU - Yuasa, Yuji

AU - Amano, Yasuo

AU - Tanimoto, Akihiro

AU - Saito, Yoko

AU - Yoshioka, Kunihiro

AU - Kita, Miho

AU - Kumazaki, Tatsuo

AU - Hiramatsu, Kyoichi

PY - 2008/9

Y1 - 2008/9

N2 - Purpose: To determine the appropriate dose of contrast medium for moving-table MR angiography (MT-MRA) from the abdominal aorta to the ankle by comparing visualization with different doses of meglumine gadopentetate (Gd-DTPA) administered in crossover fashion to normal volunteers. Materials and Methods: Twelve healthy adults underwent imaging after crossover administration of 0.1 and 0.2 mmol/kg of Gd-DTPA in random order. Continuous MT-MRA was performed with a fast 3D spoiled gradient echo sequence without parallel imaging technique. Visualization was evaluated in a total of 252 arteries by three blinded readers who independently rated arterial visualization using a 5-grade scale. Signal Intensity was determined and the blood concentration of Gd-DTPA was estimated. Results: Arterial visualization in the lower leg region was significantly better with a dose of 0.2 mmol/kg than with 0.1 mmol/kg (P < 0.001). For all regions assessed the estimated blood Gd-DTPA level was significantly higher with 0.2 mmol/kg than with 0.1 mmol/kg (abdominal aorta, P = 0.030; superficial femoral artery, P < 0.001; posterior tibial artery, P = 0.039). The vascular signal enhancement ratio and artery-to-muscle signal ratio were significantly higher in the upper leg and lower leg regions at 0.2 mmol/kg. Conclusion: With continuous MT-MRA imaging from the abdomen to the ankle in normal volunteers, better arterial visualization and superior contrast were achieved with 0.2 mmol/kg of Gd-DTPA.

AB - Purpose: To determine the appropriate dose of contrast medium for moving-table MR angiography (MT-MRA) from the abdominal aorta to the ankle by comparing visualization with different doses of meglumine gadopentetate (Gd-DTPA) administered in crossover fashion to normal volunteers. Materials and Methods: Twelve healthy adults underwent imaging after crossover administration of 0.1 and 0.2 mmol/kg of Gd-DTPA in random order. Continuous MT-MRA was performed with a fast 3D spoiled gradient echo sequence without parallel imaging technique. Visualization was evaluated in a total of 252 arteries by three blinded readers who independently rated arterial visualization using a 5-grade scale. Signal Intensity was determined and the blood concentration of Gd-DTPA was estimated. Results: Arterial visualization in the lower leg region was significantly better with a dose of 0.2 mmol/kg than with 0.1 mmol/kg (P < 0.001). For all regions assessed the estimated blood Gd-DTPA level was significantly higher with 0.2 mmol/kg than with 0.1 mmol/kg (abdominal aorta, P = 0.030; superficial femoral artery, P < 0.001; posterior tibial artery, P = 0.039). The vascular signal enhancement ratio and artery-to-muscle signal ratio were significantly higher in the upper leg and lower leg regions at 0.2 mmol/kg. Conclusion: With continuous MT-MRA imaging from the abdomen to the ankle in normal volunteers, better arterial visualization and superior contrast were achieved with 0.2 mmol/kg of Gd-DTPA.

KW - Comparative studies

KW - Contrast medium

KW - Cross-over administration

KW - Meglumine gadopentetate

KW - Moving-table MR angiography

KW - MR angiography

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