Arthritis and ankylosis in twy mice with hereditary multiple osteochondral lesions: With special reference to calcium deposition

Michiie Sakamoto, Y. Hosoda, K. Kojimahara, T. Yamazaki, Y. Yoshimura

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

A murine autosomal recessive mutant named twy (tiptoe walking-Yoshimura) mouse showing multiple osteochondral lesions including ankylosis of the vertebral column and limb joints underwent sequential histopathological analysis of posterior limb joint lesions and intervertebral disc lesions. In the articular cartilage, a decrease in alcian blue-positive extracellular matrix and the presence of degenerated collagen fibers were found at the age of around 4-8 weeks. Calcium deposits in the articular cartilage were found at that time and later in the articular space and synovial tissue. Calcium deposits were also found in the intervertebral discs at 4 weeks. Using electron microscopy, some of the crystals were seen inside small vesicles. In both joints, degeneration of, and calcium deposition in, the articular cartilage progressed with age, finally producing bony ankylosis. These histological observations suggest that calcification and degeneration of the articular cartilage are the major factors in the pathogenesis of joint disorders in the twy mouse, and this mutant mouse provides a good model for studying the process and mechanism of osteoarthritic lesions, destructive arthritis and ankylosis.

Original languageEnglish
Pages (from-to)420-427
Number of pages8
JournalPathology International
Volume44
Issue number6
Publication statusPublished - 1994
Externally publishedYes

Fingerprint

Ankylosis
Walking
Arthritis
Articular Cartilage
Joints
Calcium
Intervertebral Disc
Extremities
Alcian Blue
Extracellular Matrix
Electron Microscopy
Spine
Collagen

Keywords

  • animal model
  • calcification
  • osteoarthritis

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Arthritis and ankylosis in twy mice with hereditary multiple osteochondral lesions : With special reference to calcium deposition. / Sakamoto, Michiie; Hosoda, Y.; Kojimahara, K.; Yamazaki, T.; Yoshimura, Y.

In: Pathology International, Vol. 44, No. 6, 1994, p. 420-427.

Research output: Contribution to journalArticle

@article{2415f5f46f6c407aac7b4ca2914c950a,
title = "Arthritis and ankylosis in twy mice with hereditary multiple osteochondral lesions: With special reference to calcium deposition",
abstract = "A murine autosomal recessive mutant named twy (tiptoe walking-Yoshimura) mouse showing multiple osteochondral lesions including ankylosis of the vertebral column and limb joints underwent sequential histopathological analysis of posterior limb joint lesions and intervertebral disc lesions. In the articular cartilage, a decrease in alcian blue-positive extracellular matrix and the presence of degenerated collagen fibers were found at the age of around 4-8 weeks. Calcium deposits in the articular cartilage were found at that time and later in the articular space and synovial tissue. Calcium deposits were also found in the intervertebral discs at 4 weeks. Using electron microscopy, some of the crystals were seen inside small vesicles. In both joints, degeneration of, and calcium deposition in, the articular cartilage progressed with age, finally producing bony ankylosis. These histological observations suggest that calcification and degeneration of the articular cartilage are the major factors in the pathogenesis of joint disorders in the twy mouse, and this mutant mouse provides a good model for studying the process and mechanism of osteoarthritic lesions, destructive arthritis and ankylosis.",
keywords = "animal model, calcification, osteoarthritis",
author = "Michiie Sakamoto and Y. Hosoda and K. Kojimahara and T. Yamazaki and Y. Yoshimura",
year = "1994",
language = "English",
volume = "44",
pages = "420--427",
journal = "Pathology International",
issn = "1320-5463",
publisher = "Wiley-Blackwell",
number = "6",

}

TY - JOUR

T1 - Arthritis and ankylosis in twy mice with hereditary multiple osteochondral lesions

T2 - With special reference to calcium deposition

AU - Sakamoto, Michiie

AU - Hosoda, Y.

AU - Kojimahara, K.

AU - Yamazaki, T.

AU - Yoshimura, Y.

PY - 1994

Y1 - 1994

N2 - A murine autosomal recessive mutant named twy (tiptoe walking-Yoshimura) mouse showing multiple osteochondral lesions including ankylosis of the vertebral column and limb joints underwent sequential histopathological analysis of posterior limb joint lesions and intervertebral disc lesions. In the articular cartilage, a decrease in alcian blue-positive extracellular matrix and the presence of degenerated collagen fibers were found at the age of around 4-8 weeks. Calcium deposits in the articular cartilage were found at that time and later in the articular space and synovial tissue. Calcium deposits were also found in the intervertebral discs at 4 weeks. Using electron microscopy, some of the crystals were seen inside small vesicles. In both joints, degeneration of, and calcium deposition in, the articular cartilage progressed with age, finally producing bony ankylosis. These histological observations suggest that calcification and degeneration of the articular cartilage are the major factors in the pathogenesis of joint disorders in the twy mouse, and this mutant mouse provides a good model for studying the process and mechanism of osteoarthritic lesions, destructive arthritis and ankylosis.

AB - A murine autosomal recessive mutant named twy (tiptoe walking-Yoshimura) mouse showing multiple osteochondral lesions including ankylosis of the vertebral column and limb joints underwent sequential histopathological analysis of posterior limb joint lesions and intervertebral disc lesions. In the articular cartilage, a decrease in alcian blue-positive extracellular matrix and the presence of degenerated collagen fibers were found at the age of around 4-8 weeks. Calcium deposits in the articular cartilage were found at that time and later in the articular space and synovial tissue. Calcium deposits were also found in the intervertebral discs at 4 weeks. Using electron microscopy, some of the crystals were seen inside small vesicles. In both joints, degeneration of, and calcium deposition in, the articular cartilage progressed with age, finally producing bony ankylosis. These histological observations suggest that calcification and degeneration of the articular cartilage are the major factors in the pathogenesis of joint disorders in the twy mouse, and this mutant mouse provides a good model for studying the process and mechanism of osteoarthritic lesions, destructive arthritis and ankylosis.

KW - animal model

KW - calcification

KW - osteoarthritis

UR - http://www.scopus.com/inward/record.url?scp=0028228997&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028228997&partnerID=8YFLogxK

M3 - Article

C2 - 8055108

AN - SCOPUS:0028228997

VL - 44

SP - 420

EP - 427

JO - Pathology International

JF - Pathology International

SN - 1320-5463

IS - 6

ER -