Aryl hydrocarbon receptor deficiency in T cells suppresses the development of collagen-induced arthritis

Taisuke Nakahama, Akihiro Kimura, Nam Trung Nguyen, Ichino Chinen, Hamza Hanieh, Keiko Nohara, Yoshiaki Fujii-Kuriyama, Tadamitsu Kishimoto

Research output: Contribution to journalArticle

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Abstract

The contributions of aryl hydrocarbon receptor (Ahr) to the pathogenesis of rheumatoid arthritis have not been elucidated. Here, we show that Ahr deficiency ameliorated collagen-induced arthritis, a mouse model of RA. Collagen-immunized Ahr KO mice showed decreased serum levels of such proinflammatory cytokines as IL-1β and IL-6. The Th17 and Th1 cell populations in lymph nodes from these mice decreased and increased, respectively, whereas the percentage of regulatory T cells was unchanged. Interestingly, a lack of Ahr specifically in T cells significantly suppressed collagen-induced arthritis development, whereas Ahr deficiency in macrophages had no effect. These finding indicate that the development of experimental autoimmune arthritis depends on the presence of Ahr in T cells, and that Th1/Th17 balance may be particularly important for this process.

Original languageEnglish
Pages (from-to)14222-14227
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Volume108
Issue number34
DOIs
Publication statusPublished - 2011 Aug 23

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Aryl Hydrocarbon Receptors
Experimental Arthritis
T-Lymphocytes
Th17 Cells
Th1 Cells
Regulatory T-Lymphocytes
Interleukin-1
Interleukin-6
Rheumatoid Arthritis
Collagen
Lymph Nodes
Macrophages
Cytokines
Serum
Population

Keywords

  • Autoimmunity
  • Dioxin receptor
  • Immune regulation

ASJC Scopus subject areas

  • General

Cite this

Aryl hydrocarbon receptor deficiency in T cells suppresses the development of collagen-induced arthritis. / Nakahama, Taisuke; Kimura, Akihiro; Trung Nguyen, Nam; Chinen, Ichino; Hanieh, Hamza; Nohara, Keiko; Fujii-Kuriyama, Yoshiaki; Kishimoto, Tadamitsu.

In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 108, No. 34, 23.08.2011, p. 14222-14227.

Research output: Contribution to journalArticle

Nakahama, T, Kimura, A, Trung Nguyen, N, Chinen, I, Hanieh, H, Nohara, K, Fujii-Kuriyama, Y & Kishimoto, T 2011, 'Aryl hydrocarbon receptor deficiency in T cells suppresses the development of collagen-induced arthritis', Proceedings of the National Academy of Sciences of the United States of America, vol. 108, no. 34, pp. 14222-14227. https://doi.org/10.1073/pnas.1111786108
Nakahama, Taisuke ; Kimura, Akihiro ; Trung Nguyen, Nam ; Chinen, Ichino ; Hanieh, Hamza ; Nohara, Keiko ; Fujii-Kuriyama, Yoshiaki ; Kishimoto, Tadamitsu. / Aryl hydrocarbon receptor deficiency in T cells suppresses the development of collagen-induced arthritis. In: Proceedings of the National Academy of Sciences of the United States of America. 2011 ; Vol. 108, No. 34. pp. 14222-14227.
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