Aspirin and eicosapentaenoic acid may arrest progressive IgA nephropathy: A potential alternative to immunosuppression

Junichi Hirahashi, Norio Hanafusa, Takehiko Wada, Makoto Arita, Keiichi Hishikawa, Matsuhiko Hayashi, Masaomi Nangaku

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Immunoglobulin (Ig) A nephropathy is a prevalent form of primary glomerulonephritis, which leads to end-stage renal failure in a significant proportion of patients. Immunotherapy, including steroid use, is widely used to induce disease remission; however, it can cause serious side effects. We herein report 3 cases of progressive IgA nephropathy and their successful treatment with a combination of aspirin and eicosapentaenoic acid (EPA) without the use of steroids. The precise mechanism responsible for the combination therapy is still unknown; however, aspirin may potentiate the production of anti-inflammatory lipid mediators derived from EPA. Further clinical trials are required to substantiate this treatment regimen.

Original languageEnglish
Pages (from-to)2377-2382
Number of pages6
JournalInternal Medicine
Volume54
Issue number18
DOIs
Publication statusPublished - 2015 Sep 15

Fingerprint

Eicosapentaenoic Acid
Immunosuppression
Immunoglobulin A
Aspirin
IGA Glomerulonephritis
Steroids
Glomerulonephritis
Immunotherapy
Chronic Kidney Failure
Anti-Inflammatory Agents
Therapeutics
Clinical Trials
Lipids

Keywords

  • Aspirin
  • Eicosapentaenoic acid
  • IgA nephropathy
  • Steroids

ASJC Scopus subject areas

  • Internal Medicine

Cite this

Aspirin and eicosapentaenoic acid may arrest progressive IgA nephropathy : A potential alternative to immunosuppression. / Hirahashi, Junichi; Hanafusa, Norio; Wada, Takehiko; Arita, Makoto; Hishikawa, Keiichi; Hayashi, Matsuhiko; Nangaku, Masaomi.

In: Internal Medicine, Vol. 54, No. 18, 15.09.2015, p. 2377-2382.

Research output: Contribution to journalArticle

Hirahashi, Junichi ; Hanafusa, Norio ; Wada, Takehiko ; Arita, Makoto ; Hishikawa, Keiichi ; Hayashi, Matsuhiko ; Nangaku, Masaomi. / Aspirin and eicosapentaenoic acid may arrest progressive IgA nephropathy : A potential alternative to immunosuppression. In: Internal Medicine. 2015 ; Vol. 54, No. 18. pp. 2377-2382.
@article{959feed6be434697804577bbabd4e58d,
title = "Aspirin and eicosapentaenoic acid may arrest progressive IgA nephropathy: A potential alternative to immunosuppression",
abstract = "Immunoglobulin (Ig) A nephropathy is a prevalent form of primary glomerulonephritis, which leads to end-stage renal failure in a significant proportion of patients. Immunotherapy, including steroid use, is widely used to induce disease remission; however, it can cause serious side effects. We herein report 3 cases of progressive IgA nephropathy and their successful treatment with a combination of aspirin and eicosapentaenoic acid (EPA) without the use of steroids. The precise mechanism responsible for the combination therapy is still unknown; however, aspirin may potentiate the production of anti-inflammatory lipid mediators derived from EPA. Further clinical trials are required to substantiate this treatment regimen.",
keywords = "Aspirin, Eicosapentaenoic acid, IgA nephropathy, Steroids",
author = "Junichi Hirahashi and Norio Hanafusa and Takehiko Wada and Makoto Arita and Keiichi Hishikawa and Matsuhiko Hayashi and Masaomi Nangaku",
year = "2015",
month = "9",
day = "15",
doi = "10.2169/internalmedicine.54.4623",
language = "English",
volume = "54",
pages = "2377--2382",
journal = "Internal Medicine",
issn = "0918-2918",
publisher = "Japanese Society of Internal Medicine",
number = "18",

}

TY - JOUR

T1 - Aspirin and eicosapentaenoic acid may arrest progressive IgA nephropathy

T2 - A potential alternative to immunosuppression

AU - Hirahashi, Junichi

AU - Hanafusa, Norio

AU - Wada, Takehiko

AU - Arita, Makoto

AU - Hishikawa, Keiichi

AU - Hayashi, Matsuhiko

AU - Nangaku, Masaomi

PY - 2015/9/15

Y1 - 2015/9/15

N2 - Immunoglobulin (Ig) A nephropathy is a prevalent form of primary glomerulonephritis, which leads to end-stage renal failure in a significant proportion of patients. Immunotherapy, including steroid use, is widely used to induce disease remission; however, it can cause serious side effects. We herein report 3 cases of progressive IgA nephropathy and their successful treatment with a combination of aspirin and eicosapentaenoic acid (EPA) without the use of steroids. The precise mechanism responsible for the combination therapy is still unknown; however, aspirin may potentiate the production of anti-inflammatory lipid mediators derived from EPA. Further clinical trials are required to substantiate this treatment regimen.

AB - Immunoglobulin (Ig) A nephropathy is a prevalent form of primary glomerulonephritis, which leads to end-stage renal failure in a significant proportion of patients. Immunotherapy, including steroid use, is widely used to induce disease remission; however, it can cause serious side effects. We herein report 3 cases of progressive IgA nephropathy and their successful treatment with a combination of aspirin and eicosapentaenoic acid (EPA) without the use of steroids. The precise mechanism responsible for the combination therapy is still unknown; however, aspirin may potentiate the production of anti-inflammatory lipid mediators derived from EPA. Further clinical trials are required to substantiate this treatment regimen.

KW - Aspirin

KW - Eicosapentaenoic acid

KW - IgA nephropathy

KW - Steroids

UR - http://www.scopus.com/inward/record.url?scp=84941584496&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84941584496&partnerID=8YFLogxK

U2 - 10.2169/internalmedicine.54.4623

DO - 10.2169/internalmedicine.54.4623

M3 - Article

C2 - 26370865

AN - SCOPUS:84941584496

VL - 54

SP - 2377

EP - 2382

JO - Internal Medicine

JF - Internal Medicine

SN - 0918-2918

IS - 18

ER -