Assembly of 3D microstructures powered by cells

Kaori Kuribayashi, Hiroaki Onoe, Shoji Takeuchi

Research output: Chapter in Book/Report/Conference proceedingConference contribution

7 Citations (Scopus)

Abstract

This paper describes a method for assembly of three-dimensional (3D) microstructures powered by cell traction forces. We seeded cells onto the parylene microplates on a glass substrate; the cells were adhered and stretched onto the plates. Immediately after detaching the plates from the substrate, the plates were lifted and folded up into 3D structures due to the traction forces caused by stretched cells between two plates. Using this method we demonstrated to produce regular dodecahedrons (cell balls). Also, we successfully reconstructed 3D co-cultured structures with different kinds of the cells. We believe that this method is useful to fold 2D plates into 3D microstructures.

Original languageEnglish
Title of host publicationProceedings of Conference, MicroTAS 2009 - The 13th International Conference on Miniaturized Systems for Chemistry and Life Sciences
PublisherChemical and Biological Microsystems Society
Pages1321-1323
Number of pages3
ISBN (Print)9780979806421
Publication statusPublished - 2009 Jan 1
Externally publishedYes
Event13th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2009 - Jeju, Korea, Republic of
Duration: 2009 Nov 12009 Nov 5

Publication series

NameProceedings of Conference, MicroTAS 2009 - The 13th International Conference on Miniaturized Systems for Chemistry and Life Sciences

Other

Other13th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2009
CountryKorea, Republic of
CityJeju
Period09/11/109/11/5

Keywords

  • 3D structure
  • Cells tractionforce
  • MPC polymer
  • Parylene

ASJC Scopus subject areas

  • Chemical Engineering (miscellaneous)
  • Bioengineering

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