Assembly of human organs from stem cells to study liver disease

Kan Handa, Kentaro Matsubara, Ken Fukumitsu, Jorge Guzman-Lepe, Alicia Watson, Alejandro Soto-Gutierrez

Research output: Contribution to journalReview article

15 Citations (Scopus)

Abstract

Recently, significant developments in the field of liver tissue engineering have raised new possibilities for the study of complex physiological and pathophysiological processes in vitro, as well as the potential to assemble entire organs for transplantation. Human-induced pluripotent stem cells have been differentiated into relatively functional populations of hepatic cells, and novel techniques to generate whole organ acellular three-dimensional scaffolds have been developed. In this review, we highlight the most recent advances in organ assembly regarding the development of liver tissue in vitro. We emphasize applications that involve multiple types of cells with a biomimetic spatial organization for which three-dimensional configurations could be used for drug development or to explain mechanisms of disease. We also discuss applications of liver organotypic surrogates and the challenges of translating the highly promising new field of tissue engineering into a proven platform for predicting drug metabolism and toxicity.

Original languageEnglish
Pages (from-to)348-357
Number of pages10
JournalAmerican Journal of Pathology
Volume184
Issue number2
DOIs
Publication statusPublished - 2014 Feb

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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    Handa, K., Matsubara, K., Fukumitsu, K., Guzman-Lepe, J., Watson, A., & Soto-Gutierrez, A. (2014). Assembly of human organs from stem cells to study liver disease. American Journal of Pathology, 184(2), 348-357. https://doi.org/10.1016/j.ajpath.2013.11.003