Assessment of olfactory detection thresholds in children with autism spectrum disorders using a pulse ejection system

Hirokazu Kumazaki, Taro Muramatsu, Takashi X. Fujisawa, Masutomo Miyao, Eri Matsuura, Ken ichi Okada, Hirotaka Kosaka, Akemi Tomoda, Masaru Mimura

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Background: Atypical responsiveness to olfactory stimuli has been reported as the strongest predictor of social impairment in children with autism spectrum disorders (ASD). However, previous laboratory-based sensory psychophysical studies that have aimed to investigate olfactory sensitivity in children with ASD have produced inconsistent results. The methodology of these studies is limited by several factors, and more sophisticated approaches are required to produce consistent results. Methods: We measured olfactory detection thresholds in children with ASD and typical development (TD) using a pulse ejection system-a newly developed methodology designed to resolve problems encountered in previous studies. The two odorants used as stimuli were isoamyl acetate and allyl caproate. Results: Forty-three participants took part in this study: 23 (6 females, 17 males) children with ASD and 20 with TD (6 females, 14 males). Olfactory detection thresholds of children with ASD were significantly higher than those of TD children with both isoamyl acetate (2.85 ± 0.28 vs 1.57 ± 0.15; p <0.001) and allyl caproate ( 3.30 ± 0.23 vs 1.17 ± 0.08; p <0.001). Conclusions: We found impaired olfactory detection thresholds in children with ASD. Our results contribute to a better understanding of the olfactory abnormalities that children with ASD experience. Considering the role and effect that odors play in our daily lives, insensitivity to some odorants might have a tremendous impact on children with ASD. Future studies of olfactory processing in ASD may reveal important links between brain function, clinically relevant behavior, and treatment.

Original languageEnglish
JournalMolecular Autism
DOIs
Publication statusAccepted/In press - 2016 Jan 19

Fingerprint

Autism Spectrum Disorder
Child Development
Brain
Odorants
allyl caproate
isoamyl acetate
Therapeutics

Keywords

  • Autism spectrum disorder
  • Laboratory-based studies
  • Olfaction
  • Olfactory detection threshold
  • Pulse ejection system

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Developmental Neuroscience
  • Developmental Biology
  • Molecular Biology

Cite this

Assessment of olfactory detection thresholds in children with autism spectrum disorders using a pulse ejection system. / Kumazaki, Hirokazu; Muramatsu, Taro; Fujisawa, Takashi X.; Miyao, Masutomo; Matsuura, Eri; Okada, Ken ichi; Kosaka, Hirotaka; Tomoda, Akemi; Mimura, Masaru.

In: Molecular Autism, 19.01.2016.

Research output: Contribution to journalArticle

Kumazaki, Hirokazu ; Muramatsu, Taro ; Fujisawa, Takashi X. ; Miyao, Masutomo ; Matsuura, Eri ; Okada, Ken ichi ; Kosaka, Hirotaka ; Tomoda, Akemi ; Mimura, Masaru. / Assessment of olfactory detection thresholds in children with autism spectrum disorders using a pulse ejection system. In: Molecular Autism. 2016.
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abstract = "Background: Atypical responsiveness to olfactory stimuli has been reported as the strongest predictor of social impairment in children with autism spectrum disorders (ASD). However, previous laboratory-based sensory psychophysical studies that have aimed to investigate olfactory sensitivity in children with ASD have produced inconsistent results. The methodology of these studies is limited by several factors, and more sophisticated approaches are required to produce consistent results. Methods: We measured olfactory detection thresholds in children with ASD and typical development (TD) using a pulse ejection system-a newly developed methodology designed to resolve problems encountered in previous studies. The two odorants used as stimuli were isoamyl acetate and allyl caproate. Results: Forty-three participants took part in this study: 23 (6 females, 17 males) children with ASD and 20 with TD (6 females, 14 males). Olfactory detection thresholds of children with ASD were significantly higher than those of TD children with both isoamyl acetate (2.85 ± 0.28 vs 1.57 ± 0.15; p <0.001) and allyl caproate ( 3.30 ± 0.23 vs 1.17 ± 0.08; p <0.001). Conclusions: We found impaired olfactory detection thresholds in children with ASD. Our results contribute to a better understanding of the olfactory abnormalities that children with ASD experience. Considering the role and effect that odors play in our daily lives, insensitivity to some odorants might have a tremendous impact on children with ASD. Future studies of olfactory processing in ASD may reveal important links between brain function, clinically relevant behavior, and treatment.",
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N2 - Background: Atypical responsiveness to olfactory stimuli has been reported as the strongest predictor of social impairment in children with autism spectrum disorders (ASD). However, previous laboratory-based sensory psychophysical studies that have aimed to investigate olfactory sensitivity in children with ASD have produced inconsistent results. The methodology of these studies is limited by several factors, and more sophisticated approaches are required to produce consistent results. Methods: We measured olfactory detection thresholds in children with ASD and typical development (TD) using a pulse ejection system-a newly developed methodology designed to resolve problems encountered in previous studies. The two odorants used as stimuli were isoamyl acetate and allyl caproate. Results: Forty-three participants took part in this study: 23 (6 females, 17 males) children with ASD and 20 with TD (6 females, 14 males). Olfactory detection thresholds of children with ASD were significantly higher than those of TD children with both isoamyl acetate (2.85 ± 0.28 vs 1.57 ± 0.15; p <0.001) and allyl caproate ( 3.30 ± 0.23 vs 1.17 ± 0.08; p <0.001). Conclusions: We found impaired olfactory detection thresholds in children with ASD. Our results contribute to a better understanding of the olfactory abnormalities that children with ASD experience. Considering the role and effect that odors play in our daily lives, insensitivity to some odorants might have a tremendous impact on children with ASD. Future studies of olfactory processing in ASD may reveal important links between brain function, clinically relevant behavior, and treatment.

AB - Background: Atypical responsiveness to olfactory stimuli has been reported as the strongest predictor of social impairment in children with autism spectrum disorders (ASD). However, previous laboratory-based sensory psychophysical studies that have aimed to investigate olfactory sensitivity in children with ASD have produced inconsistent results. The methodology of these studies is limited by several factors, and more sophisticated approaches are required to produce consistent results. Methods: We measured olfactory detection thresholds in children with ASD and typical development (TD) using a pulse ejection system-a newly developed methodology designed to resolve problems encountered in previous studies. The two odorants used as stimuli were isoamyl acetate and allyl caproate. Results: Forty-three participants took part in this study: 23 (6 females, 17 males) children with ASD and 20 with TD (6 females, 14 males). Olfactory detection thresholds of children with ASD were significantly higher than those of TD children with both isoamyl acetate (2.85 ± 0.28 vs 1.57 ± 0.15; p <0.001) and allyl caproate ( 3.30 ± 0.23 vs 1.17 ± 0.08; p <0.001). Conclusions: We found impaired olfactory detection thresholds in children with ASD. Our results contribute to a better understanding of the olfactory abnormalities that children with ASD experience. Considering the role and effect that odors play in our daily lives, insensitivity to some odorants might have a tremendous impact on children with ASD. Future studies of olfactory processing in ASD may reveal important links between brain function, clinically relevant behavior, and treatment.

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