Abstract
Background: Pulmonary hypertension (PH) leads to chronic right heart failure, which is associated with an increase in sympathetic tone. The reaction affects adversely hemodynamics. We investigated heart rate turbulence (HRT), autonomic activity marker in relation to hemodynamics in patients with PH. Methods: We enrolled 38 patients with PH (mean age 44±15 years, 33 women). All patients underwent a 24-hour Holter electrocardiogram and a right cardiac Catheterization. We assessed two HRT parameters: turbulence onset (TO) and turbulence slope (TS) and hemodynamic indices: pulmonary artery (PA) pressure and pulmonary vascular resistance (PVR). According to previously published reports, TO>0% and TS<2.5msec/RRI were defined as abnormal, respectively. Results: Of the enrolled patients, two HRT parameters were utilized in 28 patients. A mean PA pressure and PVR in abnormal TO patients were worse than those in normal TO patients (50±11 versus 42±12 mmHg, P=0.04; 12 ±5 versus 8±2 wood unit, P=0.01, respectively). However, no significant difference of hemodynamic indices was achieved between abnormal and normal TS patients. Conclusions: HRT was not so strongly associated with hemodynamic indices in patients with PH because results of two parameters were not concordant.
| Original language | English |
|---|---|
| Number of pages | 1 |
| Journal | journal of arrhythmia |
| Volume | 27 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - 2011 Jan 1 |
| Externally published | Yes |
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Keywords
- heart rate turbulence
- hemodynamicity
- pulmonary hypertension
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine
Cite this
Assessment of Relationship between Heart Rate Turbulence Parameters and Hemodynamic Indices in Patients with Pulmonary Hypertension. / Kimura, Go; Miwa, Yosuke; Hoshida, Kyoko; Taguchi, Hiroki; Miyakoshi, Mutsumi; Kataoka, Masaharu; Mera, Hisaaki; Yusu, Satoru; Sato, Toshiaki; Sato, Toru; Yoshino, Hideaki; Ikeda, Takanori.
In: journal of arrhythmia, Vol. 27, No. 4, 01.01.2011.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Assessment of Relationship between Heart Rate Turbulence Parameters and Hemodynamic Indices in Patients with Pulmonary Hypertension
AU - Kimura, Go
AU - Miwa, Yosuke
AU - Hoshida, Kyoko
AU - Taguchi, Hiroki
AU - Miyakoshi, Mutsumi
AU - Kataoka, Masaharu
AU - Mera, Hisaaki
AU - Yusu, Satoru
AU - Sato, Toshiaki
AU - Sato, Toru
AU - Yoshino, Hideaki
AU - Ikeda, Takanori
PY - 2011/1/1
Y1 - 2011/1/1
N2 - Background: Pulmonary hypertension (PH) leads to chronic right heart failure, which is associated with an increase in sympathetic tone. The reaction affects adversely hemodynamics. We investigated heart rate turbulence (HRT), autonomic activity marker in relation to hemodynamics in patients with PH. Methods: We enrolled 38 patients with PH (mean age 44±15 years, 33 women). All patients underwent a 24-hour Holter electrocardiogram and a right cardiac Catheterization. We assessed two HRT parameters: turbulence onset (TO) and turbulence slope (TS) and hemodynamic indices: pulmonary artery (PA) pressure and pulmonary vascular resistance (PVR). According to previously published reports, TO>0% and TS<2.5msec/RRI were defined as abnormal, respectively. Results: Of the enrolled patients, two HRT parameters were utilized in 28 patients. A mean PA pressure and PVR in abnormal TO patients were worse than those in normal TO patients (50±11 versus 42±12 mmHg, P=0.04; 12 ±5 versus 8±2 wood unit, P=0.01, respectively). However, no significant difference of hemodynamic indices was achieved between abnormal and normal TS patients. Conclusions: HRT was not so strongly associated with hemodynamic indices in patients with PH because results of two parameters were not concordant.
AB - Background: Pulmonary hypertension (PH) leads to chronic right heart failure, which is associated with an increase in sympathetic tone. The reaction affects adversely hemodynamics. We investigated heart rate turbulence (HRT), autonomic activity marker in relation to hemodynamics in patients with PH. Methods: We enrolled 38 patients with PH (mean age 44±15 years, 33 women). All patients underwent a 24-hour Holter electrocardiogram and a right cardiac Catheterization. We assessed two HRT parameters: turbulence onset (TO) and turbulence slope (TS) and hemodynamic indices: pulmonary artery (PA) pressure and pulmonary vascular resistance (PVR). According to previously published reports, TO>0% and TS<2.5msec/RRI were defined as abnormal, respectively. Results: Of the enrolled patients, two HRT parameters were utilized in 28 patients. A mean PA pressure and PVR in abnormal TO patients were worse than those in normal TO patients (50±11 versus 42±12 mmHg, P=0.04; 12 ±5 versus 8±2 wood unit, P=0.01, respectively). However, no significant difference of hemodynamic indices was achieved between abnormal and normal TS patients. Conclusions: HRT was not so strongly associated with hemodynamic indices in patients with PH because results of two parameters were not concordant.
KW - heart rate turbulence
KW - hemodynamicity
KW - pulmonary hypertension
UR - http://www.scopus.com/inward/record.url?scp=85009625526&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85009625526&partnerID=8YFLogxK
U2 - 10.4020/jhrs.27.PJ1_100
DO - 10.4020/jhrs.27.PJ1_100
M3 - Article
VL - 27
JO - Journal of Arrhythmia
JF - Journal of Arrhythmia
SN - 1880-4276
IS - 4
ER -