Association analysis of the NOD2 gene with susceptibility to graft-versus-host disease in a Japanese population

Tsuyoshi Tanabe, Natsu Yamaguchi, Koichi Matsuda, Keiko Yamazaki, Satoshi Takahashi, Arinobu Tojo, Makoto Onizuka, Yoshinobu Eishi, Hideki Akiyama, Jun Ishikawa, Takehiko Mori, Masamichi Hara, Kazutoshi Koike, Keisei Kawa, Takakazu Kawase, Yasuo Morishima, Hiroki Amano, Mikiko Kobayashi-Miura, Takeyasu Kakamu, Yusuke NakamuraShigetaka Asano, Yasuyuki Fujita

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Members of the nucleotide-binding oligomerization domain (NOD)-like receptor (NLR) family participate in the innate immune system, exerting widespread effects on cytokine secretion, autophagy, and apoptosis. Recent studies in Caucasians revealed the association between mutants of NOD2, a member of the NLR family, and severity of acute graft-versus-host disease (GVHD). NOD2 polymorphism screening has been recommended for donor selection and risk assessment at bone marrow transplantation. To investigate whether NOD2 plays a role in the pathogenesis of GVHD in a Japanese population, we examined DNA from 142 bone marrow transplant patient/donor pairs to detect genetic variation in the NOD2 gene. No genetic variants of NOD2 were associated with the severity of acute GVHD in our patients. However, a weak association between a single nucleotide polymorphism in the NOD2 gene (R471C) and acute myeloid leukemia in the bone marrow patients (p = 0.029, odds ratio 4.08, 95% CI 1.22-13.67) was detected. This polymorphism was not prevalent in 479 Crohn's disease (CD) patients in Japan. These results suggest that, in the Japanese population, unlike the Caucasian, NOD2 is not a major contributor to susceptibility to severe acute GVHD.

Original languageEnglish
Pages (from-to)771-778
Number of pages8
JournalInternational journal of hematology
Volume93
Issue number6
DOIs
Publication statusPublished - 2011 Jun

Keywords

  • Crohn's disease
  • GVHD
  • Innate immunity
  • Leukemia
  • NLR
  • NOD2

ASJC Scopus subject areas

  • Hematology

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    Tanabe, T., Yamaguchi, N., Matsuda, K., Yamazaki, K., Takahashi, S., Tojo, A., Onizuka, M., Eishi, Y., Akiyama, H., Ishikawa, J., Mori, T., Hara, M., Koike, K., Kawa, K., Kawase, T., Morishima, Y., Amano, H., Kobayashi-Miura, M., Kakamu, T., ... Fujita, Y. (2011). Association analysis of the NOD2 gene with susceptibility to graft-versus-host disease in a Japanese population. International journal of hematology, 93(6), 771-778. https://doi.org/10.1007/s12185-011-0860-5