Association between γ-glutamyl transpeptidase activity and status of disorders constituting insulin resistance syndrome

Hirokazu Yokoyama, Susumu Moriya, Yasuhiko Homma, Tetsuhei Ogawa

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Background: Serum γ-glutamyl transferase (γGTP) activity is a well-established marker of alcohol consumption. However, recently, a correlation between serum γGTP activity and insulin resistance status has been demonstrated. Methods: To determine whether serum γGTP activity could be associated with the status of various disorders caused by increased insulin resistance levels, namely, insulin resistance syndrome, a cross-sectional study for 11,884 Japanese men was performed. They were divided into three groups by their age, and associations between γGTP and various indexes of insulin resistance syndrome were studied by multiple logistic regression analysis in which subjects' drinking styles were corrected for in each age bracket. Results: Consuming ethanol more than 40 g/day, body mass index more than 25.9 kg/m2, and triglyceride levels more than 150 mg/dl were significant risk factors accounting for increased γGTP activity (more than 78 IU/liters) irrespective of age. In addition, when subjects of 40 to 59 years old were selectively studied, hypertension, hypercholesteremia, hyperuricemia, and increased glycohemoglobin A1C levels were also significant risk factors for increased γGTP activity. Conclusions: There are significant associations between γGTP and the status of insulin resistance syndrome. In addition to excessive alcohol consumption, the status of insulin resistance syndrome could affect subjects' γGTP activities.

Original languageEnglish
JournalAlcoholism: Clinical and Experimental Research
Volume27
Issue number8 SUPPL.
Publication statusPublished - 2003 Aug 1

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gamma-Glutamyltransferase
Guanosine Triphosphate
Insulin Resistance
Insulin
Alcohol Drinking
Serum
Alcohols
Hyperuricemia
Transferases
Hypercholesterolemia
Regression analysis
Drinking
Logistics
Triglycerides
Body Mass Index
Ethanol
Age Groups
Cross-Sectional Studies
Logistic Models
Regression Analysis

Keywords

  • γGTP
  • Ethanol consumption
  • Insulin resistance syndrome

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Toxicology

Cite this

Association between γ-glutamyl transpeptidase activity and status of disorders constituting insulin resistance syndrome. / Yokoyama, Hirokazu; Moriya, Susumu; Homma, Yasuhiko; Ogawa, Tetsuhei.

In: Alcoholism: Clinical and Experimental Research, Vol. 27, No. 8 SUPPL., 01.08.2003.

Research output: Contribution to journalArticle

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