Association between a polymorphism of aminolevulinate dehydrogenase (ALAD) gene and blood lead levels in Japanese subjects

Koichi Miyaki, Htay Lwin, Katsunori Masaki, Yixuan Song, Yoshimitsu Takahashi, Masaaki Muramatsu, Takeo Nakayama

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

This cross-sectional study investigated the relationship between the aminolevulinate dehydrogenase (ALAD) genotype and blood lead levels among 101 Japanese workers. Blood lead concentration measurement, biomarkers, and genotyping were performed. The minor allele frequency (MAF) for ALAD (ALAD2) was 0.08. Although the blood lead level in the subjects with heterozygous GC genotype was significantly higher than those with homozygous GG genotype, there were no significant differences for hemoglobin, hematocrit, serum and urinary ALA levels among genotypes. ALAD2 genotype was significantly associated with the blood lead concentration, even in the environmental lead exposed subjects. Further confirmation with a large sample size is needed.

Original languageEnglish
Pages (from-to)999-1009
Number of pages11
JournalInternational journal of environmental research and public health
Volume6
Issue number3
DOIs
Publication statusPublished - 2009 Mar 1

Fingerprint

Oxidoreductases
Genotype
Genes
Hematocrit
Gene Frequency
Sample Size
Hemoglobins
Cross-Sectional Studies
Biomarkers
Serum
Lead

Keywords

  • Alad gene
  • Blood lead level
  • Environmentally lead exposure
  • Japanese

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Health, Toxicology and Mutagenesis

Cite this

Association between a polymorphism of aminolevulinate dehydrogenase (ALAD) gene and blood lead levels in Japanese subjects. / Miyaki, Koichi; Lwin, Htay; Masaki, Katsunori; Song, Yixuan; Takahashi, Yoshimitsu; Muramatsu, Masaaki; Nakayama, Takeo.

In: International journal of environmental research and public health, Vol. 6, No. 3, 01.03.2009, p. 999-1009.

Research output: Contribution to journalArticle

Miyaki, Koichi ; Lwin, Htay ; Masaki, Katsunori ; Song, Yixuan ; Takahashi, Yoshimitsu ; Muramatsu, Masaaki ; Nakayama, Takeo. / Association between a polymorphism of aminolevulinate dehydrogenase (ALAD) gene and blood lead levels in Japanese subjects. In: International journal of environmental research and public health. 2009 ; Vol. 6, No. 3. pp. 999-1009.
@article{0eee7629dc3245718981fe4a89523094,
title = "Association between a polymorphism of aminolevulinate dehydrogenase (ALAD) gene and blood lead levels in Japanese subjects",
abstract = "This cross-sectional study investigated the relationship between the aminolevulinate dehydrogenase (ALAD) genotype and blood lead levels among 101 Japanese workers. Blood lead concentration measurement, biomarkers, and genotyping were performed. The minor allele frequency (MAF) for ALAD (ALAD2) was 0.08. Although the blood lead level in the subjects with heterozygous GC genotype was significantly higher than those with homozygous GG genotype, there were no significant differences for hemoglobin, hematocrit, serum and urinary ALA levels among genotypes. ALAD2 genotype was significantly associated with the blood lead concentration, even in the environmental lead exposed subjects. Further confirmation with a large sample size is needed.",
keywords = "Alad gene, Blood lead level, Environmentally lead exposure, Japanese",
author = "Koichi Miyaki and Htay Lwin and Katsunori Masaki and Yixuan Song and Yoshimitsu Takahashi and Masaaki Muramatsu and Takeo Nakayama",
year = "2009",
month = "3",
day = "1",
doi = "10.3390/ijerph6030999",
language = "English",
volume = "6",
pages = "999--1009",
journal = "International Journal of Environmental Research and Public Health",
issn = "1661-7827",
publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",
number = "3",

}

TY - JOUR

T1 - Association between a polymorphism of aminolevulinate dehydrogenase (ALAD) gene and blood lead levels in Japanese subjects

AU - Miyaki, Koichi

AU - Lwin, Htay

AU - Masaki, Katsunori

AU - Song, Yixuan

AU - Takahashi, Yoshimitsu

AU - Muramatsu, Masaaki

AU - Nakayama, Takeo

PY - 2009/3/1

Y1 - 2009/3/1

N2 - This cross-sectional study investigated the relationship between the aminolevulinate dehydrogenase (ALAD) genotype and blood lead levels among 101 Japanese workers. Blood lead concentration measurement, biomarkers, and genotyping were performed. The minor allele frequency (MAF) for ALAD (ALAD2) was 0.08. Although the blood lead level in the subjects with heterozygous GC genotype was significantly higher than those with homozygous GG genotype, there were no significant differences for hemoglobin, hematocrit, serum and urinary ALA levels among genotypes. ALAD2 genotype was significantly associated with the blood lead concentration, even in the environmental lead exposed subjects. Further confirmation with a large sample size is needed.

AB - This cross-sectional study investigated the relationship between the aminolevulinate dehydrogenase (ALAD) genotype and blood lead levels among 101 Japanese workers. Blood lead concentration measurement, biomarkers, and genotyping were performed. The minor allele frequency (MAF) for ALAD (ALAD2) was 0.08. Although the blood lead level in the subjects with heterozygous GC genotype was significantly higher than those with homozygous GG genotype, there were no significant differences for hemoglobin, hematocrit, serum and urinary ALA levels among genotypes. ALAD2 genotype was significantly associated with the blood lead concentration, even in the environmental lead exposed subjects. Further confirmation with a large sample size is needed.

KW - Alad gene

KW - Blood lead level

KW - Environmentally lead exposure

KW - Japanese

UR - http://www.scopus.com/inward/record.url?scp=67649233791&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=67649233791&partnerID=8YFLogxK

U2 - 10.3390/ijerph6030999

DO - 10.3390/ijerph6030999

M3 - Article

VL - 6

SP - 999

EP - 1009

JO - International Journal of Environmental Research and Public Health

JF - International Journal of Environmental Research and Public Health

SN - 1661-7827

IS - 3

ER -