Association between adjuvant regional radiotherapy and cognitive function in breast cancer patients treated with conservation therapy

Osamu Shibayama, Kazuhiro Yoshiuchi, Masatoshi Inagaki, Yutaka Matsuoka, Eisho Yoshikawa, Yuriko Sugawara, Tatsuo Akechi, Noriaki Wada, Shigeru Imoto, Koji Murakami, Asao Ogawa, Akira Akabayashi, Yosuke Uchitomi

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Although protracted cognitive impairment has been reported to occur after radiotherapy even when such therapy is not directed to brain areas, the mechanism remains unclear. This study investigated whether breast cancer patients exposed to local radiotherapy showed lower cognitive function mediated by higher plasma interleukin (IL)-6 levels than those unexposed. We performed the Wechsler Memory Scale-Revised (WMS-R) and measured plasma IL-6 levels for 105 breast cancer surgical patients within 1 year after the initial therapy. The group differences in each of the indices of WMS-R were investigated between cancer patients exposed to adjuvant regional radiotherapy (n = 51) and those unexposed (n = 54) using analysis of covariance. We further investigated a mediation effect by plasma IL-6 levels on the relationship between radiotherapy and the indices of WMS-R using the bootstrapping method. The radiotherapy group showed significantly lower Immediate Verbal Memory Index and Delayed Recall Index (P = 0.001, P = 0.008, respectively). Radiotherapy exerted an indirect effect on the lower Delayed Recall Index of WMS-R through elevation of plasma IL-6 levels (bootstrap 95% confidence interval = -2.6626 to -0.0402). This study showed that breast cancer patients exposed to adjuvant regional radiotherapy in conservation therapy might have cognitive impairment even several months after their treatment. The relationship between the therapy and the cognitive impairment could be partially mediated by elevation of plasma IL-6 levels.

Original languageEnglish
Pages (from-to)702-709
Number of pages8
JournalCancer Medicine
Volume3
Issue number3
DOIs
Publication statusPublished - 2014 Jun 1
Externally publishedYes

Fingerprint

Adjuvant Radiotherapy
Wechsler Scales
Cognition
Interleukin-6
Radiotherapy
Breast Neoplasms
Therapeutics
Short-Term Memory
Confidence Intervals
Brain
Cognitive Dysfunction
Neoplasms

Keywords

  • Breast cancer
  • cognitive impairment
  • interleukin-6
  • radiotherapy
  • Wechsler Memory Scale-Revised

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Shibayama, O., Yoshiuchi, K., Inagaki, M., Matsuoka, Y., Yoshikawa, E., Sugawara, Y., ... Uchitomi, Y. (2014). Association between adjuvant regional radiotherapy and cognitive function in breast cancer patients treated with conservation therapy. Cancer Medicine, 3(3), 702-709. https://doi.org/10.1002/cam4.174

Association between adjuvant regional radiotherapy and cognitive function in breast cancer patients treated with conservation therapy. / Shibayama, Osamu; Yoshiuchi, Kazuhiro; Inagaki, Masatoshi; Matsuoka, Yutaka; Yoshikawa, Eisho; Sugawara, Yuriko; Akechi, Tatsuo; Wada, Noriaki; Imoto, Shigeru; Murakami, Koji; Ogawa, Asao; Akabayashi, Akira; Uchitomi, Yosuke.

In: Cancer Medicine, Vol. 3, No. 3, 01.06.2014, p. 702-709.

Research output: Contribution to journalArticle

Shibayama, O, Yoshiuchi, K, Inagaki, M, Matsuoka, Y, Yoshikawa, E, Sugawara, Y, Akechi, T, Wada, N, Imoto, S, Murakami, K, Ogawa, A, Akabayashi, A & Uchitomi, Y 2014, 'Association between adjuvant regional radiotherapy and cognitive function in breast cancer patients treated with conservation therapy', Cancer Medicine, vol. 3, no. 3, pp. 702-709. https://doi.org/10.1002/cam4.174
Shibayama, Osamu ; Yoshiuchi, Kazuhiro ; Inagaki, Masatoshi ; Matsuoka, Yutaka ; Yoshikawa, Eisho ; Sugawara, Yuriko ; Akechi, Tatsuo ; Wada, Noriaki ; Imoto, Shigeru ; Murakami, Koji ; Ogawa, Asao ; Akabayashi, Akira ; Uchitomi, Yosuke. / Association between adjuvant regional radiotherapy and cognitive function in breast cancer patients treated with conservation therapy. In: Cancer Medicine. 2014 ; Vol. 3, No. 3. pp. 702-709.
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