Association between Asian dust exposure and respiratory function in children with bronchial asthma in Nagasaki Prefecture, Japan

Takahiro Nakamura, Yuji Nishiwaki, Kunio Hashimoto, Ayano Takeuchi, Tasuku Kitajima, Kazuhiro Komori, Kasumi Tashiro, Hideki Hasunuma, Kayo Ueda, Atsushi Shimizu, Hiroshi Odajima, Hiroyuki Moriuchi, Masahiro Hashizume

Research output: Contribution to journalArticle

Abstract

Background: Studies on the adverse effects of Asian dust (AD) on respiratory function in children are scarce. The objective of this study was to examine the association between AD and respiratory function by measuring peak expiratory flow rates (PEFRs) in asthmatic children. Methods: The study was carried out from March to May from 2014 through 2016. One hundred ten children with bronchial asthma were recruited from four hospitals in the Goto Islands and south Nagasaki area in Nagasaki prefecture. The parents were asked to record their children's PEFRs every morning/evening and clinical symptoms in an asthma diary. AD was assessed from light detection and ranging data, and a linear mixed-effects model was used to estimate the effects of AD on daily PEFR. Time-stratified case-crossover analyses were performed to examine the association between AD and asthma attacks defined by reduction levels in PEFR. Results: AD was detected on 11 days in the Goto Islands, and on 23 days in the south Nagasaki area. After adjusting for age, sex, temperature, and daily oxidants, we found a consistent association between AD and a 1.1% to 1.7% decrease in PEFR in the mornings and a 0.7% to 1.3% decrease in the evenings at a lag of 0 to 5 days. AD was not associated with the number of asthma attacks, respiratory symptoms, or other symptoms at any lag days examined. Conclusions: Exposure to AD was associated with reduced PEFR, although the effects were not large enough to induce clinically apparent symptoms, in clinically well-controlled asthmatic children.

Original languageEnglish
Article number8
JournalEnvironmental Health and Preventive Medicine
Volume25
Issue number1
DOIs
Publication statusPublished - 2020 Mar 4

Keywords

  • Asian dust
  • Bronchial asthma
  • Children
  • Peak expiratory flow rate

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health

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    Nakamura, T., Nishiwaki, Y., Hashimoto, K., Takeuchi, A., Kitajima, T., Komori, K., Tashiro, K., Hasunuma, H., Ueda, K., Shimizu, A., Odajima, H., Moriuchi, H., & Hashizume, M. (2020). Association between Asian dust exposure and respiratory function in children with bronchial asthma in Nagasaki Prefecture, Japan. Environmental Health and Preventive Medicine, 25(1), [8]. https://doi.org/10.1186/s12199-020-00846-9