Association Between Clinical Backgrounds and Malignant Progression of Suspected Intraductal Papillary Mucinous Neoplasm

Genki Fukushima, Kodai Abe, Minoru Kitago, Eisuke Iwasaki, Aya Hirata, Ryo Takemura, Ryota Ishii, Hiroshi Yagi, Yuta Abe, Yasushi Hasegawa, Seiichiro Fukuhara, Shutaro Hori, Masayuki Tanaka, Yutaka Nakano, Takahiro Yokose, Gaku Shimane, Yuko Kitagawa

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

Objectives Some intraductal papillary mucinous neoplasms (IPMNs) have malignant potential and can become pancreatic cancer. The mechanism behind the malignant progression of IPMN remains unknown. We aimed to identify the risk factors and interactions between backgrounds for IPMN. Methods We retrospectively enrolled 980 patients of pancreatic cancer or suspected IPMN (sIPMN) who underwent endoscopic ultrasound or retrograde cholangiopancreatography. We classified them into pancreatic cancer, high-risk sIPMN, and low-risk sIPMN, and investigated the risk factors for high-risk sIPMN. Results Smoking habits (odds ratio [OR], 3.74; 95% confidence interval [CI], 2.04-6.85; P < 0.001), serum carbohydrate antigen 19-9 ≥37 U/mL (OR, 6.30; 95% CI, 2.88-13.80; P < 0.001), and family history of cancers (OR, 2.38; 95% CI, 1.30-4.37; P = 0.005) were independent risk factors for high-risk suspected IPMN. Odds ratios of diabetes and neutrophil-to-lymphocyte ratio of 2.45 or greater were significantly higher in patients with a family history of cancer than those without a family history of cancer (OR, 3.28; 95% CI, 0.52-20.80 vs 1.85; 95% CI, 0.78-4.41; OR, 2.44; 95% CI, 0.81-7.34 vs 1.24; 95% CI, 0.67-2.30, respectively). Conclusions Understanding the interactions between background factors can effectively prevent IPMNs' malignant transformation.

Original languageEnglish
Pages (from-to)617-623
Number of pages7
JournalPancreas
Volume51
Issue number6
DOIs
Publication statusPublished - 2022 Jul 1

Keywords

  • family history
  • malignancy
  • neutrophil-to-lymphocyte ratio
  • pancreatic neoplasms
  • risk factors

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Hepatology
  • Endocrinology

Fingerprint

Dive into the research topics of 'Association Between Clinical Backgrounds and Malignant Progression of Suspected Intraductal Papillary Mucinous Neoplasm'. Together they form a unique fingerprint.

Cite this