TY - JOUR
T1 - Association Between Fatty Acid Intakes and Age-Related Macular Degeneration in a Japanese Population
T2 - JPHC-NEXT Eye Study
AU - Yasukawa, Tomoyo
AU - Sasaki, Mariko
AU - Motomura, Kaoru
AU - Yuki, Kenya
AU - Kurihara, Toshihide
AU - Tomita, Yohei
AU - Mori, Kiwako
AU - Ozawa, Nobuhiro
AU - Ozawa, Yoko
AU - Yamagishi, Kazumasa
AU - Hanyuda, Akiko
AU - Sawada, Norie
AU - Tsubota, Kazuo
AU - Tsugane, Shoichiro
AU - Iso, Hiroyasu
N1 - Funding Information:
Supported in part by a Grant-in-Aid for Scientific Research from the Japan Society for the Promotion of Science, Japan (JSPS KAKENHI, 20K10490) to MS. The cohort study was originally supported by the National Cancer Center Research and Development Fund.
Funding Information:
The authors thank the medical staff for their techni-cal assistance and all staff members in Chikusei City for their extensive efforts to conduct the survey. We also thank Hidemasa Torii, Yusaku Katada, Erisa Yotsukura, Hiromitsu Kunimi, and Mari Ibuki, Keio University School of Medicine for their cooperation in the diagnosis on retinal fundus images. Supported in part by a Grant-in-Aid for Scientific Research from the Japan Society for the Promotion of Science, Japan (JSPS KAKENHI, 20K10490) to MS. The cohort study was originally supported by the National Cancer Center Research and Development Fund.
Publisher Copyright:
© 2023 The Authors.
PY - 2023/1/1
Y1 - 2023/1/1
N2 - Purpose: To determine the associations between fatty acid intakes and the prevalence of age-related macular degeneration (AMD) under a population-based cross-sectional study. Methods: Residents of Chikusei City aged ≥40 years underwent systemic and eye screening. AMD was graded according to a modified version of the Age-Related Eye Disease Study classification. Dietary intake was assessed using a food frequency questionnaire and was adjusted for total energy intake. Results: Altogether, 10,788 eyes of 5394 participants, 2116 men (mean [standard devia-tion (SD)] age, 62.4 [9.4] years) and 3278 women (60.6 [9.5] years), were included. The mean daily total fat intakes were 52.8 g and 59.0 g in men and women, respectively. After adjustments for potential confounders, saturated fatty acid (SFA) intake was inversely associated with the prevalence of any AMD in men (for each energy-adjusted 1-SD increase: odds ratio [OR], 0.86; 95% confidence interval [CI], 0.74–1.00). Significant trends were found for decreasing odds ratios of AMD with increasing SFA, monounsaturated fatty acid (MUFA), and polyunsaturated fatty acid (PUFA) intake (P for trend = 0.02, 0.04, and 0.04, respectively). In women, only a significant association was observed between the second quartile of linolenic acid intake and the prevalence of any AMD (OR, 0.78; 95% CI, 0.62–0.99). Conclusions: We found an inverse association of SFA intake and a weak inverse association of MUFA and PUFA intakes with the prevalence of any AMD in a Japanese popula-tion. Translational Relevance: Adequate fatty acid intake may be necessary to prevent or decelerate AMD.
AB - Purpose: To determine the associations between fatty acid intakes and the prevalence of age-related macular degeneration (AMD) under a population-based cross-sectional study. Methods: Residents of Chikusei City aged ≥40 years underwent systemic and eye screening. AMD was graded according to a modified version of the Age-Related Eye Disease Study classification. Dietary intake was assessed using a food frequency questionnaire and was adjusted for total energy intake. Results: Altogether, 10,788 eyes of 5394 participants, 2116 men (mean [standard devia-tion (SD)] age, 62.4 [9.4] years) and 3278 women (60.6 [9.5] years), were included. The mean daily total fat intakes were 52.8 g and 59.0 g in men and women, respectively. After adjustments for potential confounders, saturated fatty acid (SFA) intake was inversely associated with the prevalence of any AMD in men (for each energy-adjusted 1-SD increase: odds ratio [OR], 0.86; 95% confidence interval [CI], 0.74–1.00). Significant trends were found for decreasing odds ratios of AMD with increasing SFA, monounsaturated fatty acid (MUFA), and polyunsaturated fatty acid (PUFA) intake (P for trend = 0.02, 0.04, and 0.04, respectively). In women, only a significant association was observed between the second quartile of linolenic acid intake and the prevalence of any AMD (OR, 0.78; 95% CI, 0.62–0.99). Conclusions: We found an inverse association of SFA intake and a weak inverse association of MUFA and PUFA intakes with the prevalence of any AMD in a Japanese popula-tion. Translational Relevance: Adequate fatty acid intake may be necessary to prevent or decelerate AMD.
KW - age-related macular degeneration
KW - dietaryintake
KW - epidemiology
KW - fattyacids
KW - retina
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UR - http://www.scopus.com/inward/citedby.url?scp=85145428442&partnerID=8YFLogxK
U2 - 10.1167/tvst.12.1.3
DO - 10.1167/tvst.12.1.3
M3 - Article
C2 - 36595278
AN - SCOPUS:85145428442
SN - 2164-2591
VL - 12
JO - Translational Vision Science and Technology
JF - Translational Vision Science and Technology
IS - 1
M1 - 3
ER -