Association Between Inflammatory Diet Pattern and Risk of Colorectal Carcinoma Subtypes Classified by Immune Responses to Tumor

Li Liu, Reiko Nishihara, Zhi Rong Qian, Fred K. Tabung, Daniel Nevo, Xuehong Zhang, Mingyang Song, Yin Cao, Kosuke Mima, Yohei Masugi, Yan Shi, Annacarolina da Silva, Tyler Twombly, Mancang Gu, Wanwan Li, Tsuyoshi Hamada, Keisuke Kosumi, Kentaro Inamura, Jonathan A. Nowak, David A. DrewPaul Lochhead, Katsuhiko Nosho, Kana Wu, Molin Wang, Wendy S. Garrett, Andrew T. Chan, Charles S. Fuchs, Edward L. Giovannucci, Shuji Ogino

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Background & Aims Dietary patterns affect systemic and local intestinal inflammation, which have been linked to colorectal carcinogenesis. Chronic inflammation can interfere with the adaptive immune response. We investigated whether the association of a diet that promotes intestinal inflammation with risk of colorectal carcinoma was stronger for tumors with lower lymphocytic reactions than tumors with higher lymphocytic reactions. Methods We collected data from the molecular pathological epidemiology databases of 2 prospective cohort studies: the Nurses’ Health Study (since 1976) and the Health Professionals Follow-Up Study (since 1986). We used duplication-method time-varying Cox proportional cause-specific hazards regression to assess the association of empirical dietary inflammatory pattern (EDIP) score (derived from food frequency questionnaire data) with colorectal carcinoma subtype. Foods that contribute to high EDIP scores include red and processed meats, refined grains, carbonated beverages, and some vegetables; foods that contribute to low EDIP scores include beer, wine, coffee, tea, yellow and leafy vegetables, and fruit juice. Colorectal tissue samples were analyzed histologically for patterns of lymphocytic reactions (Crohn's-like lymphoid reaction, peritumoral lymphocytic reaction, intratumoral periglandular reaction, and tumor-infiltrating lymphocytes). Results During follow-up of 124,433 participants, we documented 1311 incident colon and rectal cancer cases with available tissue data. The association between the EDIP and colorectal cancer risk was significant (Ptrend =.02), and varied with degree of peritumoral lymphocytic reaction (Pheterogeneity <.001). Higher EDIP scores were associated with increased risk of colorectal cancer with an absent or low peritumoral lymphocytic reaction (highest vs lowest EDIP score quintile hazard ratio, 2.60; 95% confidence interval, 1.60−4.23; Ptrend <.001), but not risk of tumors with intermediate or high peritumoral lymphocytic reaction (Ptrend >.80). Conclusions In 2 prospective cohort studies, we associated inflammatory diets with a higher risk of colorectal cancer subtype that contains little or no peritumoral lymphocytic reaction. These findings suggest that diet-related inflammation might contribute to development of colorectal cancer, by suppressing the adaptive anti-tumor immune response.

Original languageEnglish
Pages (from-to)1517-1530.e14
JournalGastroenterology
Volume153
Issue number6
DOIs
Publication statusPublished - 2017 Dec

Keywords

  • Adaptive Immune Cells
  • BRAF
  • CpG Island Methylator Phenotype
  • Cyclooxygenase-2

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology

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    Liu, L., Nishihara, R., Qian, Z. R., Tabung, F. K., Nevo, D., Zhang, X., Song, M., Cao, Y., Mima, K., Masugi, Y., Shi, Y., da Silva, A., Twombly, T., Gu, M., Li, W., Hamada, T., Kosumi, K., Inamura, K., Nowak, J. A., ... Ogino, S. (2017). Association Between Inflammatory Diet Pattern and Risk of Colorectal Carcinoma Subtypes Classified by Immune Responses to Tumor. Gastroenterology, 153(6), 1517-1530.e14. https://doi.org/10.1053/j.gastro.2017.08.045