Association between J-point elevation and death from coronary artery disease

15-year follow-up of the NIPPON DATA90

Takashi Hisamatsu, Takayoshi Ohkubo, Katsuyuki Miura, Takashi Yamamoto, Akira Fujiyoshi, Naoko Miyagawa, Aya Kadota, Naoyuki Takashima, Shin ya Nagasawa, Yoshikuni Kita, Yoshitaka Murakami, Akira Okayama, Minoru Horie, Tomonori Okamura, Hirotsugu Ueshima

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Background: An early repolarization pattern, characterized by an elevation of the QRS-ST junction (J-point) on 12-lead electrocardiography (ECG) is associated with cardiac and sudden death. However, little is known about the prognostic significance of J-point elevation for various disease-specific cardiovascular outcomes, including coronary artery disease (CAD). Methods and Results: To investigate the association between the presence of J-point elevation ≥0.1 mV and various disease-specific cardiovascular outcomes, we conducted a 15-year prospective study in a representative general Japanese population of 7,630 individuals (41% men, mean age 52.4 years) who participated in the National Survey of Circulatory Disorders. Cox models were used to estimate the hazard ratios (HRs) adjusted for possible confounding factors. J-point elevation was present in 264 individuals (3.5%) and was associated with an increased risk of cardiac death (adjusted HR, 2.54; 95% confidence interval [CI] 1.40-4.58; P=0.002) and death from CAD (adjusted HR, 4.66; 95% CI 2.30-9.46; P<0.001). In a subgroup analysis by age, the association between J-point elevation and cardiovascular outcomes was more remarkable in middle-aged (<60 years) than in older individuals (≥60 years) (all P for interaction <0.05). Conclusions: J-point elevation on standard 12-lead ECG was an independent predictor of cardiac death and death from CAD in a representative sample of the general Japanese population, particularly among the middle-aged.

Original languageEnglish
Pages (from-to)1260-1266
Number of pages7
JournalCirculation Journal
Volume77
Issue number5
DOIs
Publication statusPublished - 2013

Fingerprint

Coronary Artery Disease
Electrocardiography
Cardiovascular Diseases
Confidence Intervals
Sudden Cardiac Death
Proportional Hazards Models
Population
Prospective Studies
Lead

Keywords

  • Cardiovascular diseases
  • Coronary artery disease
  • Electrocardiography
  • Epidemiology
  • J-point

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Hisamatsu, T., Ohkubo, T., Miura, K., Yamamoto, T., Fujiyoshi, A., Miyagawa, N., ... Ueshima, H. (2013). Association between J-point elevation and death from coronary artery disease: 15-year follow-up of the NIPPON DATA90. Circulation Journal, 77(5), 1260-1266. https://doi.org/10.1253/circj.CJ-12-1273

Association between J-point elevation and death from coronary artery disease : 15-year follow-up of the NIPPON DATA90. / Hisamatsu, Takashi; Ohkubo, Takayoshi; Miura, Katsuyuki; Yamamoto, Takashi; Fujiyoshi, Akira; Miyagawa, Naoko; Kadota, Aya; Takashima, Naoyuki; Nagasawa, Shin ya; Kita, Yoshikuni; Murakami, Yoshitaka; Okayama, Akira; Horie, Minoru; Okamura, Tomonori; Ueshima, Hirotsugu.

In: Circulation Journal, Vol. 77, No. 5, 2013, p. 1260-1266.

Research output: Contribution to journalArticle

Hisamatsu, T, Ohkubo, T, Miura, K, Yamamoto, T, Fujiyoshi, A, Miyagawa, N, Kadota, A, Takashima, N, Nagasawa, SY, Kita, Y, Murakami, Y, Okayama, A, Horie, M, Okamura, T & Ueshima, H 2013, 'Association between J-point elevation and death from coronary artery disease: 15-year follow-up of the NIPPON DATA90', Circulation Journal, vol. 77, no. 5, pp. 1260-1266. https://doi.org/10.1253/circj.CJ-12-1273
Hisamatsu, Takashi ; Ohkubo, Takayoshi ; Miura, Katsuyuki ; Yamamoto, Takashi ; Fujiyoshi, Akira ; Miyagawa, Naoko ; Kadota, Aya ; Takashima, Naoyuki ; Nagasawa, Shin ya ; Kita, Yoshikuni ; Murakami, Yoshitaka ; Okayama, Akira ; Horie, Minoru ; Okamura, Tomonori ; Ueshima, Hirotsugu. / Association between J-point elevation and death from coronary artery disease : 15-year follow-up of the NIPPON DATA90. In: Circulation Journal. 2013 ; Vol. 77, No. 5. pp. 1260-1266.
@article{87d0a1c5b03242c88b7bcc5be918b59a,
title = "Association between J-point elevation and death from coronary artery disease: 15-year follow-up of the NIPPON DATA90",
abstract = "Background: An early repolarization pattern, characterized by an elevation of the QRS-ST junction (J-point) on 12-lead electrocardiography (ECG) is associated with cardiac and sudden death. However, little is known about the prognostic significance of J-point elevation for various disease-specific cardiovascular outcomes, including coronary artery disease (CAD). Methods and Results: To investigate the association between the presence of J-point elevation ≥0.1 mV and various disease-specific cardiovascular outcomes, we conducted a 15-year prospective study in a representative general Japanese population of 7,630 individuals (41{\%} men, mean age 52.4 years) who participated in the National Survey of Circulatory Disorders. Cox models were used to estimate the hazard ratios (HRs) adjusted for possible confounding factors. J-point elevation was present in 264 individuals (3.5{\%}) and was associated with an increased risk of cardiac death (adjusted HR, 2.54; 95{\%} confidence interval [CI] 1.40-4.58; P=0.002) and death from CAD (adjusted HR, 4.66; 95{\%} CI 2.30-9.46; P<0.001). In a subgroup analysis by age, the association between J-point elevation and cardiovascular outcomes was more remarkable in middle-aged (<60 years) than in older individuals (≥60 years) (all P for interaction <0.05). Conclusions: J-point elevation on standard 12-lead ECG was an independent predictor of cardiac death and death from CAD in a representative sample of the general Japanese population, particularly among the middle-aged.",
keywords = "Cardiovascular diseases, Coronary artery disease, Electrocardiography, Epidemiology, J-point",
author = "Takashi Hisamatsu and Takayoshi Ohkubo and Katsuyuki Miura and Takashi Yamamoto and Akira Fujiyoshi and Naoko Miyagawa and Aya Kadota and Naoyuki Takashima and Nagasawa, {Shin ya} and Yoshikuni Kita and Yoshitaka Murakami and Akira Okayama and Minoru Horie and Tomonori Okamura and Hirotsugu Ueshima",
year = "2013",
doi = "10.1253/circj.CJ-12-1273",
language = "English",
volume = "77",
pages = "1260--1266",
journal = "Circulation Journal",
issn = "1346-9843",
publisher = "Japanese Circulation Society",
number = "5",

}

TY - JOUR

T1 - Association between J-point elevation and death from coronary artery disease

T2 - 15-year follow-up of the NIPPON DATA90

AU - Hisamatsu, Takashi

AU - Ohkubo, Takayoshi

AU - Miura, Katsuyuki

AU - Yamamoto, Takashi

AU - Fujiyoshi, Akira

AU - Miyagawa, Naoko

AU - Kadota, Aya

AU - Takashima, Naoyuki

AU - Nagasawa, Shin ya

AU - Kita, Yoshikuni

AU - Murakami, Yoshitaka

AU - Okayama, Akira

AU - Horie, Minoru

AU - Okamura, Tomonori

AU - Ueshima, Hirotsugu

PY - 2013

Y1 - 2013

N2 - Background: An early repolarization pattern, characterized by an elevation of the QRS-ST junction (J-point) on 12-lead electrocardiography (ECG) is associated with cardiac and sudden death. However, little is known about the prognostic significance of J-point elevation for various disease-specific cardiovascular outcomes, including coronary artery disease (CAD). Methods and Results: To investigate the association between the presence of J-point elevation ≥0.1 mV and various disease-specific cardiovascular outcomes, we conducted a 15-year prospective study in a representative general Japanese population of 7,630 individuals (41% men, mean age 52.4 years) who participated in the National Survey of Circulatory Disorders. Cox models were used to estimate the hazard ratios (HRs) adjusted for possible confounding factors. J-point elevation was present in 264 individuals (3.5%) and was associated with an increased risk of cardiac death (adjusted HR, 2.54; 95% confidence interval [CI] 1.40-4.58; P=0.002) and death from CAD (adjusted HR, 4.66; 95% CI 2.30-9.46; P<0.001). In a subgroup analysis by age, the association between J-point elevation and cardiovascular outcomes was more remarkable in middle-aged (<60 years) than in older individuals (≥60 years) (all P for interaction <0.05). Conclusions: J-point elevation on standard 12-lead ECG was an independent predictor of cardiac death and death from CAD in a representative sample of the general Japanese population, particularly among the middle-aged.

AB - Background: An early repolarization pattern, characterized by an elevation of the QRS-ST junction (J-point) on 12-lead electrocardiography (ECG) is associated with cardiac and sudden death. However, little is known about the prognostic significance of J-point elevation for various disease-specific cardiovascular outcomes, including coronary artery disease (CAD). Methods and Results: To investigate the association between the presence of J-point elevation ≥0.1 mV and various disease-specific cardiovascular outcomes, we conducted a 15-year prospective study in a representative general Japanese population of 7,630 individuals (41% men, mean age 52.4 years) who participated in the National Survey of Circulatory Disorders. Cox models were used to estimate the hazard ratios (HRs) adjusted for possible confounding factors. J-point elevation was present in 264 individuals (3.5%) and was associated with an increased risk of cardiac death (adjusted HR, 2.54; 95% confidence interval [CI] 1.40-4.58; P=0.002) and death from CAD (adjusted HR, 4.66; 95% CI 2.30-9.46; P<0.001). In a subgroup analysis by age, the association between J-point elevation and cardiovascular outcomes was more remarkable in middle-aged (<60 years) than in older individuals (≥60 years) (all P for interaction <0.05). Conclusions: J-point elevation on standard 12-lead ECG was an independent predictor of cardiac death and death from CAD in a representative sample of the general Japanese population, particularly among the middle-aged.

KW - Cardiovascular diseases

KW - Coronary artery disease

KW - Electrocardiography

KW - Epidemiology

KW - J-point

UR - http://www.scopus.com/inward/record.url?scp=84876779226&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84876779226&partnerID=8YFLogxK

U2 - 10.1253/circj.CJ-12-1273

DO - 10.1253/circj.CJ-12-1273

M3 - Article

VL - 77

SP - 1260

EP - 1266

JO - Circulation Journal

JF - Circulation Journal

SN - 1346-9843

IS - 5

ER -