Association between N-terminal pro B-type natriuretic peptide and day-to-day blood pressure and heart rate variability in a general population: The Ohasama study

Michihiro Satoh, Miki Hosaka, Kei Asayama, Masahiro Kikuya, Ryusuke Inoue, Hirohito Metoki, Megumi Tsubota-Utsugi, Azusa Hara, Takuo Hirose, Taku Obara, Kazuhito Totsune, Haruhisa Hoshi, Nariyasu Mano, Koichi Node, Yutaka Imai, Takayoshi Ohkubo

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Abstract

Background: In addition to day-to-day variability in blood pressure (BP) or heart rate (HR), N-terminal pro B-type natriuretic peptide (NT-proBNP) has been reported to be a predictor of cardiovascular disease. Here, we tested the hypothesis that day-to-day BP or HR variability calculated as the intraindividual standard deviation (SD) of home BP or HR is associated with elevated NT-proBNP in a cross-sectional study. Methods: Among 664 participants (mean age, 61.9 years; female, 70.5%) from a general Japanese population without a history of heart disease, 86 (13.0%) had NT-proBNP at least 125pg/ml. Results: Each 1 SD increase in the SD of home systolic BP (SBP) [odds ratio (OR), 1.82; P<.0001) and in the SD of home HR (OR, 1.44; P=0.008) were significantly associated with the prevalence of NT-proBNP at least 125pg/ml after adjustment for possible confounding factors including home SBP and HR. Among the four groups defined by the median SD of home SBP and of home HR, the group with higher SDs in home SBP (≥8.0mmHg) and HR (≥5.0bpm) had the greatest OR for the prevalence of NT-proBNP at least 125pg/ml (OR, 4.80; P=0007 vs. a reference group with lower SDs of home SBP and HR). Conclusion: These results suggest that day-to-day variability in BP and HR may be associated with target-organ damage or complications, which can lead to an elevated NT-proBNP level. An elevated NT-proBNP level may be involved in the prognostic significance of day-to-day variability in BP or HR.

Original languageEnglish
Pages (from-to)1536-1541
Number of pages6
JournalJournal of hypertension
Volume33
Issue number8
DOIs
Publication statusPublished - 2015 Aug 11
Externally publishedYes

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Keywords

  • biomarker
  • blood pressure
  • day-to-day variability
  • epidemiology
  • N -terminal pro B-type natriuretic peptide

ASJC Scopus subject areas

  • Internal Medicine
  • Physiology
  • Cardiology and Cardiovascular Medicine

Cite this

Satoh, M., Hosaka, M., Asayama, K., Kikuya, M., Inoue, R., Metoki, H., Tsubota-Utsugi, M., Hara, A., Hirose, T., Obara, T., Totsune, K., Hoshi, H., Mano, N., Node, K., Imai, Y., & Ohkubo, T. (2015). Association between N-terminal pro B-type natriuretic peptide and day-to-day blood pressure and heart rate variability in a general population: The Ohasama study. Journal of hypertension, 33(8), 1536-1541. https://doi.org/10.1097/HJH.0000000000000570