Association between PADI4 and rheumatoid arthritis

A meta-analysis

Takuji Iwamoto, K. Ikari, T. Nakamura, M. Kuwahara, Y. Toyama, T. Tomatsu, S. Momohara, N. Kamatani

Research output: Contribution to journalArticle

96 Citations (Scopus)

Abstract

Objective. Polymorphisms and haplotypes of the peptidylarginine deiminase type 4 gene (PADI4) have been reported to be associated with rheumatoid arthritis (RA) in a Japanese population. However, subsequent replication studies showed conflicting results. The aim of this study was to determine whether meta-analysis would prove the existence of the association. Methods. PubMed was searched using the term 'PADI4' for articles from the publication of the first study to December 2005. Replication studies that tested the association between PADI4 and RA were reviewed for meta-analysis. The Breslow-Day test for homogeneity across the studies was calculated. The Mantel-Haenszel procedure was used to pool odds ratios (OR) with 95% confidence intervals (CI) to evaluate the association. Results. Six replication studies, one from Japan and five from Europe and North America, fulfilled the selection criteria for inclusion in the meta-analysis. Homogeneity was confirmed across the replication studies. The common OR was 1.14 (95% CI=1.07-1.21) for allelic distribution. The association was confirmed when only five replication studies in the European descent populations were combined (P=0.0096, common OR=1.10). Conclusions. Our meta-analysis showed a positive association between PA DI4 and RA not only in the Japanese population but also in populations of European descent.

Original languageEnglish
Pages (from-to)804-807
Number of pages4
JournalRheumatology
Volume45
Issue number7
DOIs
Publication statusPublished - 2006 Jul

Fingerprint

Meta-Analysis
Rheumatoid Arthritis
Odds Ratio
Population
Genes
Confidence Intervals
North America
PubMed
Haplotypes
Patient Selection
Publications
Japan
protein-arginine deiminase

Keywords

  • Meta-analysis
  • PADI4
  • Population genetics
  • Rheumatoid arthritis
  • Susceptibility

ASJC Scopus subject areas

  • Neuroscience(all)
  • Rheumatology

Cite this

Iwamoto, T., Ikari, K., Nakamura, T., Kuwahara, M., Toyama, Y., Tomatsu, T., ... Kamatani, N. (2006). Association between PADI4 and rheumatoid arthritis: A meta-analysis. Rheumatology, 45(7), 804-807. https://doi.org/10.1093/rheumatology/kel023

Association between PADI4 and rheumatoid arthritis : A meta-analysis. / Iwamoto, Takuji; Ikari, K.; Nakamura, T.; Kuwahara, M.; Toyama, Y.; Tomatsu, T.; Momohara, S.; Kamatani, N.

In: Rheumatology, Vol. 45, No. 7, 07.2006, p. 804-807.

Research output: Contribution to journalArticle

Iwamoto, T, Ikari, K, Nakamura, T, Kuwahara, M, Toyama, Y, Tomatsu, T, Momohara, S & Kamatani, N 2006, 'Association between PADI4 and rheumatoid arthritis: A meta-analysis', Rheumatology, vol. 45, no. 7, pp. 804-807. https://doi.org/10.1093/rheumatology/kel023
Iwamoto T, Ikari K, Nakamura T, Kuwahara M, Toyama Y, Tomatsu T et al. Association between PADI4 and rheumatoid arthritis: A meta-analysis. Rheumatology. 2006 Jul;45(7):804-807. https://doi.org/10.1093/rheumatology/kel023
Iwamoto, Takuji ; Ikari, K. ; Nakamura, T. ; Kuwahara, M. ; Toyama, Y. ; Tomatsu, T. ; Momohara, S. ; Kamatani, N. / Association between PADI4 and rheumatoid arthritis : A meta-analysis. In: Rheumatology. 2006 ; Vol. 45, No. 7. pp. 804-807.
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