Association between platelet glycoprotein Ibα genotype and ischemic cerebrovascular disease

Akira Sonoda, Mitsuru Murata, Daisuke Ito, Norio Tanahashi, Atsumi Ohta, Yoko Tada, Eiko Takeshita, Tadashi Yoshida, Ikuo Saito, Masatoshi Yamamoto, Yasuo Ikeda, Yasuo Fukuuchi, Kiyoaki Watanabe

Research output: Contribution to journalArticle

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Abstract

Background and Purpose - Platelets play pivotal roles in the development of ischemic cerebrovascular disease (CVD). The platelet glycoprotein (GP) Ib/IX/V complex is a receptor for von Willebrand factor, which plays a major role in the initial phase of platelet activation under high shear stress conditions. This study was designed to investigate the association between a genetic variation of this receptor and the prevalence of CVD. Methods - Two hundred patients with ischemic CVD, as confirmed by brain CT and/or MRI, and 317 age- and sex-matched control subjects without clinical evidence of CVD or cardiovascular disease were analyzed for their genotype frequencies of the 145Thr/Met dimorphism of the α-chain of GPIb (GPIbα). Results - Genotypes with 145Met (T/M and M/M) were more frequently found in the CVD patients (26.5%) than in control subjects (14.2%, P=0.0005). The genotype effect was more obvious in those <60 years of age or without acquired cardiovascular risk factors. The odds ratio for nonsmoking women <60 years of age was 10.6 (95% confidence intervals, 2.2 to 51.7). Although the number of patients studied was small (n=24), transient ischemic attack showed the highest odds ratio (4.3, P=0.0004), followed by lacunar infarction (OR=2.2, P=0.0024) and atherothrombotic infarction (OR=1.5, P=0.3143). Logistic regression analysis revealed that the presence of Met-allele was independently associated with CVD. Conclusions - Our study suggests that the platelet GPIbα genotype is a genetic risk factor for ischemic CVD.

Original languageEnglish
Pages (from-to)493-497
Number of pages5
JournalStroke
Volume31
Issue number2
Publication statusPublished - 2000 Feb

Fingerprint

Platelet Glycoprotein GPIb-IX Complex
Platelet Membrane Glycoproteins
Cerebrovascular Disorders
Genotype
Blood Platelets
Odds Ratio
Lacunar Stroke
Transient Ischemic Attack
Platelet Activation
Infarction
Cardiovascular Diseases
Logistic Models
Alleles
Regression Analysis
Confidence Intervals
Brain

Keywords

  • Cerebrovascular disorders
  • Genetics
  • Platelets
  • Polymorphism
  • Thrombosis

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Neuroscience(all)

Cite this

Sonoda, A., Murata, M., Ito, D., Tanahashi, N., Ohta, A., Tada, Y., ... Watanabe, K. (2000). Association between platelet glycoprotein Ibα genotype and ischemic cerebrovascular disease. Stroke, 31(2), 493-497.

Association between platelet glycoprotein Ibα genotype and ischemic cerebrovascular disease. / Sonoda, Akira; Murata, Mitsuru; Ito, Daisuke; Tanahashi, Norio; Ohta, Atsumi; Tada, Yoko; Takeshita, Eiko; Yoshida, Tadashi; Saito, Ikuo; Yamamoto, Masatoshi; Ikeda, Yasuo; Fukuuchi, Yasuo; Watanabe, Kiyoaki.

In: Stroke, Vol. 31, No. 2, 02.2000, p. 493-497.

Research output: Contribution to journalArticle

Sonoda, A, Murata, M, Ito, D, Tanahashi, N, Ohta, A, Tada, Y, Takeshita, E, Yoshida, T, Saito, I, Yamamoto, M, Ikeda, Y, Fukuuchi, Y & Watanabe, K 2000, 'Association between platelet glycoprotein Ibα genotype and ischemic cerebrovascular disease', Stroke, vol. 31, no. 2, pp. 493-497.
Sonoda, Akira ; Murata, Mitsuru ; Ito, Daisuke ; Tanahashi, Norio ; Ohta, Atsumi ; Tada, Yoko ; Takeshita, Eiko ; Yoshida, Tadashi ; Saito, Ikuo ; Yamamoto, Masatoshi ; Ikeda, Yasuo ; Fukuuchi, Yasuo ; Watanabe, Kiyoaki. / Association between platelet glycoprotein Ibα genotype and ischemic cerebrovascular disease. In: Stroke. 2000 ; Vol. 31, No. 2. pp. 493-497.
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AU - Murata, Mitsuru

AU - Ito, Daisuke

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AU - Tada, Yoko

AU - Takeshita, Eiko

AU - Yoshida, Tadashi

AU - Saito, Ikuo

AU - Yamamoto, Masatoshi

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AU - Fukuuchi, Yasuo

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N2 - Background and Purpose - Platelets play pivotal roles in the development of ischemic cerebrovascular disease (CVD). The platelet glycoprotein (GP) Ib/IX/V complex is a receptor for von Willebrand factor, which plays a major role in the initial phase of platelet activation under high shear stress conditions. This study was designed to investigate the association between a genetic variation of this receptor and the prevalence of CVD. Methods - Two hundred patients with ischemic CVD, as confirmed by brain CT and/or MRI, and 317 age- and sex-matched control subjects without clinical evidence of CVD or cardiovascular disease were analyzed for their genotype frequencies of the 145Thr/Met dimorphism of the α-chain of GPIb (GPIbα). Results - Genotypes with 145Met (T/M and M/M) were more frequently found in the CVD patients (26.5%) than in control subjects (14.2%, P=0.0005). The genotype effect was more obvious in those <60 years of age or without acquired cardiovascular risk factors. The odds ratio for nonsmoking women <60 years of age was 10.6 (95% confidence intervals, 2.2 to 51.7). Although the number of patients studied was small (n=24), transient ischemic attack showed the highest odds ratio (4.3, P=0.0004), followed by lacunar infarction (OR=2.2, P=0.0024) and atherothrombotic infarction (OR=1.5, P=0.3143). Logistic regression analysis revealed that the presence of Met-allele was independently associated with CVD. Conclusions - Our study suggests that the platelet GPIbα genotype is a genetic risk factor for ischemic CVD.

AB - Background and Purpose - Platelets play pivotal roles in the development of ischemic cerebrovascular disease (CVD). The platelet glycoprotein (GP) Ib/IX/V complex is a receptor for von Willebrand factor, which plays a major role in the initial phase of platelet activation under high shear stress conditions. This study was designed to investigate the association between a genetic variation of this receptor and the prevalence of CVD. Methods - Two hundred patients with ischemic CVD, as confirmed by brain CT and/or MRI, and 317 age- and sex-matched control subjects without clinical evidence of CVD or cardiovascular disease were analyzed for their genotype frequencies of the 145Thr/Met dimorphism of the α-chain of GPIb (GPIbα). Results - Genotypes with 145Met (T/M and M/M) were more frequently found in the CVD patients (26.5%) than in control subjects (14.2%, P=0.0005). The genotype effect was more obvious in those <60 years of age or without acquired cardiovascular risk factors. The odds ratio for nonsmoking women <60 years of age was 10.6 (95% confidence intervals, 2.2 to 51.7). Although the number of patients studied was small (n=24), transient ischemic attack showed the highest odds ratio (4.3, P=0.0004), followed by lacunar infarction (OR=2.2, P=0.0024) and atherothrombotic infarction (OR=1.5, P=0.3143). Logistic regression analysis revealed that the presence of Met-allele was independently associated with CVD. Conclusions - Our study suggests that the platelet GPIbα genotype is a genetic risk factor for ischemic CVD.

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