Association between polymorphism of the AGTR1 and cardiovascular events in a Japanese general sample (The Shigaraki Study)

Shinji Tamaki; Yasuyuki Nakamura; Yasuharu Tabara; Tomonori Okamura; Hideyuki Kanda; Yoshikuni Kita; Takashi Kadowaki; Yasuyuki Tsujita; Tanvir Chowdhury Turin; Minoru Horie; Tetsuro Miki; Hirotsugu Ueshima

doi:10.1016/j.ijcard.2008.04.079

Association between polymorphism of the AGTR1 and cardiovascular events in a Japanese general sample (The Shigaraki Study)

Shinji Tamaki, Yasuyuki Nakamura, Yasuharu Tabara, Tomonori Okamura, Hideyuki Kanda, Yoshikuni Kita, Takashi Kadowaki, Yasuyuki Tsujita, Tanvir Chowdhury Turin, Minoru Horie, Tetsuro Miki, Hirotsugu Ueshima

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

We examined whether the A1166C polymorphism of the angiotensin II type I receptor gene (AGTR1) affects cardiovascular event occurrence in a Japanese prospective cohort study. The 2212 participants who gave informed consent for genetic analysis were enrolled in this study (the Shigaraki Study). The average observation period was 1954 days. Cardiovascular events occurred in 37 individuals (1.7%). The independent factors which specified cardiovascular events were age (hazard ratio (HR) = 1.13; 95% confidence interval (CI): 1.10-1.16; p < 0.0001) and sex (HR = 2.18; 95%CI: 1.23-3.85; p = 0.007). However, the A1166C polymorphism of AGTR1 was not a predictive factor for cardiovascular events (HR = 1.11; 95%CI: 0.61-2.02; p = 0.731).

Original language	English
Pages (from-to)	354-355
Number of pages	2
Journal	International Journal of Cardiology
Volume	136
Issue number	3
DOIs	https://doi.org/10.1016/j.ijcard.2008.04.079
Publication status	Published - 2009 Aug 21
Externally published	Yes

Keywords

A1166C polymorphism
AGTR1
Cardiovascular events
Prospective cohort study

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine

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10.1016/j.ijcard.2008.04.079

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Tamaki, S., Nakamura, Y., Tabara, Y., Okamura, T., Kanda, H., Kita, Y., Kadowaki, T., Tsujita, Y., Chowdhury Turin, T., Horie, M., Miki, T., & Ueshima, H. (2009). Association between polymorphism of the AGTR1 and cardiovascular events in a Japanese general sample (The Shigaraki Study). International Journal of Cardiology, 136(3), 354-355. https://doi.org/10.1016/j.ijcard.2008.04.079

Tamaki, S, Nakamura, Y, Tabara, Y, Okamura, T, Kanda, H, Kita, Y, Kadowaki, T, Tsujita, Y, Chowdhury Turin, T, Horie, M, Miki, T & Ueshima, H 2009, 'Association between polymorphism of the AGTR1 and cardiovascular events in a Japanese general sample (The Shigaraki Study)', International Journal of Cardiology, vol. 136, no. 3, pp. 354-355. https://doi.org/10.1016/j.ijcard.2008.04.079

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abstract = "We examined whether the A1166C polymorphism of the angiotensin II type I receptor gene (AGTR1) affects cardiovascular event occurrence in a Japanese prospective cohort study. The 2212 participants who gave informed consent for genetic analysis were enrolled in this study (the Shigaraki Study). The average observation period was 1954 days. Cardiovascular events occurred in 37 individuals (1.7%). The independent factors which specified cardiovascular events were age (hazard ratio (HR) = 1.13; 95% confidence interval (CI): 1.10-1.16; p < 0.0001) and sex (HR = 2.18; 95%CI: 1.23-3.85; p = 0.007). However, the A1166C polymorphism of AGTR1 was not a predictive factor for cardiovascular events (HR = 1.11; 95%CI: 0.61-2.02; p = 0.731).",

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author = "Shinji Tamaki and Yasuyuki Nakamura and Yasuharu Tabara and Tomonori Okamura and Hideyuki Kanda and Yoshikuni Kita and Takashi Kadowaki and Yasuyuki Tsujita and {Chowdhury Turin}, Tanvir and Minoru Horie and Tetsuro Miki and Hirotsugu Ueshima",

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AU - Tamaki, Shinji

AU - Nakamura, Yasuyuki

AU - Tabara, Yasuharu

AU - Okamura, Tomonori

AU - Kanda, Hideyuki

AU - Kita, Yoshikuni

AU - Kadowaki, Takashi

AU - Tsujita, Yasuyuki

AU - Chowdhury Turin, Tanvir

AU - Horie, Minoru

AU - Miki, Tetsuro

AU - Ueshima, Hirotsugu

PY - 2009/8/21

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N2 - We examined whether the A1166C polymorphism of the angiotensin II type I receptor gene (AGTR1) affects cardiovascular event occurrence in a Japanese prospective cohort study. The 2212 participants who gave informed consent for genetic analysis were enrolled in this study (the Shigaraki Study). The average observation period was 1954 days. Cardiovascular events occurred in 37 individuals (1.7%). The independent factors which specified cardiovascular events were age (hazard ratio (HR) = 1.13; 95% confidence interval (CI): 1.10-1.16; p < 0.0001) and sex (HR = 2.18; 95%CI: 1.23-3.85; p = 0.007). However, the A1166C polymorphism of AGTR1 was not a predictive factor for cardiovascular events (HR = 1.11; 95%CI: 0.61-2.02; p = 0.731).

AB - We examined whether the A1166C polymorphism of the angiotensin II type I receptor gene (AGTR1) affects cardiovascular event occurrence in a Japanese prospective cohort study. The 2212 participants who gave informed consent for genetic analysis were enrolled in this study (the Shigaraki Study). The average observation period was 1954 days. Cardiovascular events occurred in 37 individuals (1.7%). The independent factors which specified cardiovascular events were age (hazard ratio (HR) = 1.13; 95% confidence interval (CI): 1.10-1.16; p < 0.0001) and sex (HR = 2.18; 95%CI: 1.23-3.85; p = 0.007). However, the A1166C polymorphism of AGTR1 was not a predictive factor for cardiovascular events (HR = 1.11; 95%CI: 0.61-2.02; p = 0.731).

KW - A1166C polymorphism

KW - AGTR1

KW - Cardiovascular events

KW - Prospective cohort study

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Association between polymorphism of the AGTR1 and cardiovascular events in a Japanese general sample (The Shigaraki Study)

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