Association between polymorphism of the AGTR1 and cardiovascular events in a Japanese general sample (The Shigaraki Study)

Shinji Tamaki, Yasuyuki Nakamura, Yasuharu Tabara, Tomonori Okamura, Hideyuki Kanda, Yoshikuni Kita, Takashi Kadowaki, Yasuyuki Tsujita, Tanvir Chowdhury Turin, Minoru Horie, Tetsuro Miki, Hirotsugu Ueshima

Research output: Contribution to journalArticle

Abstract

We examined whether the A1166C polymorphism of the angiotensin II type I receptor gene (AGTR1) affects cardiovascular event occurrence in a Japanese prospective cohort study. The 2212 participants who gave informed consent for genetic analysis were enrolled in this study (the Shigaraki Study). The average observation period was 1954 days. Cardiovascular events occurred in 37 individuals (1.7%). The independent factors which specified cardiovascular events were age (hazard ratio (HR) = 1.13; 95% confidence interval (CI): 1.10-1.16; p < 0.0001) and sex (HR = 2.18; 95%CI: 1.23-3.85; p = 0.007). However, the A1166C polymorphism of AGTR1 was not a predictive factor for cardiovascular events (HR = 1.11; 95%CI: 0.61-2.02; p = 0.731).

Original languageEnglish
Pages (from-to)354-355
Number of pages2
JournalInternational Journal of Cardiology
Volume136
Issue number3
DOIs
Publication statusPublished - 2009 Aug 21
Externally publishedYes

Fingerprint

Confidence Intervals
Angiotensin I
Angiotensin Receptors
Sex Ratio
Informed Consent
Cohort Studies
Observation
Prospective Studies
Genes

Keywords

  • A1166C polymorphism
  • AGTR1
  • Cardiovascular events
  • Prospective cohort study

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Association between polymorphism of the AGTR1 and cardiovascular events in a Japanese general sample (The Shigaraki Study). / Tamaki, Shinji; Nakamura, Yasuyuki; Tabara, Yasuharu; Okamura, Tomonori; Kanda, Hideyuki; Kita, Yoshikuni; Kadowaki, Takashi; Tsujita, Yasuyuki; Chowdhury Turin, Tanvir; Horie, Minoru; Miki, Tetsuro; Ueshima, Hirotsugu.

In: International Journal of Cardiology, Vol. 136, No. 3, 21.08.2009, p. 354-355.

Research output: Contribution to journalArticle

Tamaki, S, Nakamura, Y, Tabara, Y, Okamura, T, Kanda, H, Kita, Y, Kadowaki, T, Tsujita, Y, Chowdhury Turin, T, Horie, M, Miki, T & Ueshima, H 2009, 'Association between polymorphism of the AGTR1 and cardiovascular events in a Japanese general sample (The Shigaraki Study)', International Journal of Cardiology, vol. 136, no. 3, pp. 354-355. https://doi.org/10.1016/j.ijcard.2008.04.079
Tamaki, Shinji ; Nakamura, Yasuyuki ; Tabara, Yasuharu ; Okamura, Tomonori ; Kanda, Hideyuki ; Kita, Yoshikuni ; Kadowaki, Takashi ; Tsujita, Yasuyuki ; Chowdhury Turin, Tanvir ; Horie, Minoru ; Miki, Tetsuro ; Ueshima, Hirotsugu. / Association between polymorphism of the AGTR1 and cardiovascular events in a Japanese general sample (The Shigaraki Study). In: International Journal of Cardiology. 2009 ; Vol. 136, No. 3. pp. 354-355.
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