Association between severity of diffuse idiopathic skeletal hyperostosis and ossification of other spinal ligaments in patients with ossification of the posterior longitudinal ligament

Japanese Organization of the Study for Ossification of Spinal Ligament (JOSL)

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Although diffuse idiopathic skeletal hyperostosis (DISH) is known to coexist with the ossification of spinal ligaments (OSLs), details of the radiographic relationship remain unclear. Methods: We prospectively collected data of 239 patients with symptomatic cervical ossification of the posterior longitudinal ligament (OPLL) and analyzed the DISH severity on whole-spine computed tomography images, using the following grades: grade 0, no DISH; grade 1, DISH at T3–T10; grade 2, DISH at both T3–T10 and C6–T2 and/or T11–L2; and grade 3, DISH beyond C5 and/or L3. Ossification indices were calculated as the sum of vertebral and intervertebral levels with OSL for each patient. Results: DISH was found in 107 patients (44.8%), 65 (60.7%) of whom had grade 2 DISH. We found significant associations of DISH grade with the indices for cervical OPLL (r = 0.45, p < 0.0001), thoracic ossification of the ligamentum flavum (OLF; r = 0.41, p < 0.0001) and thoracic ossification of the supra/interspinous ligaments (OSIL; r = 0.53, p < 0.0001). DISH grade was also correlated with the index for each OSL in the whole spine (OPLL: r = 0.29, p < 0.0001; OLF: r = 0.40, p < 0.0001; OSIL: r = 0.50, p < 0.0001). Conclusion: The DISH grade correlated with the indices of OSL at each high-prevalence level as well as the whole spine.

Original languageEnglish
Article number4690
JournalJournal of Clinical Medicine
Volume10
Issue number20
DOIs
Publication statusPublished - 2021 Oct 1

Keywords

  • Cervical ossification of the posterior longitudinal ligament
  • Diffuse idiopathic skeletal hyperostosis
  • Grading system
  • Multicenter study
  • Whole-spine computed tomography

ASJC Scopus subject areas

  • Medicine(all)

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