Association between white matter hyperintensity and lacunar infarction on MRI and subitem scores of the Japanese version of mini-mental state examination for testing cognitive decline: The Ohasama study

Eman M. Elnimr, Takeo Kondo, Yoshimi Suzukamo, Michihiro Satoh, Yutaka Oouchida, Azusa Hara, Takayoshi Ohkubo, Masahiro Kikuya, Mikio Hirano, Aya Hosokawa, Toru Hosokawa, Yutaka Imai, Shin Ichi Izumi

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We assessed whether subitem scores on the Mini-Mental State Examination (MMSE) associated independently with cerebral white matter hyperintensity (WMH) and lacunar infarction (LI). Magnetic resonance imaging (MRI) and neuropsychological evaluation (MMSE) were performed in 1008 elderly individuals from the Ohasama Study (348 men, 660 women [65.5%]; age 68.0 ± 6.0 [mean ± SD] years; MMSE score, 26.5 ± 2.9). The relationships between MRI findings and MMSE subitem scores were analyzed by logistic regression. Significant associations were observed between the MMSE subitems "Orientation to place" and WMH, and "Copy a figure" and LI. Pathological changes were detected by brain MRI associated with a decrease in cognitive function in healthy elderly individuals.

Original languageEnglish
Pages (from-to)541-547
Number of pages7
JournalClinical and Experimental Hypertension
Issue number8
Publication statusPublished - 2012 Dec 7
Externally publishedYes



  • Cognitive function
  • General population
  • Lacunar infarction
  • Silent cerebrovascular lesions
  • Stroke
  • White matter hyperintensity

ASJC Scopus subject areas

  • Internal Medicine
  • Physiology

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