Association of alcohol consumption with fat deposition in a community-based sample of Japanese men: The Shiga epidemiological study of subclinical atherosclerosis (SESSA)

Masaki Sumi, Takashi Hisamatsu, Akira Fujiyoshi, Aya Kadota, Naoko Miyagawa, Keiko Kondo, Sayaka Kadowaki, Sentaro Suzuki, Sayuki Torii, Maryam Zaid, Atsushi Sato, Hisatomi Arima, Tomohiro Terada, Katsuyuki Miura, Hirotsugu Ueshima, Minoru Horie, Yasutaka Nakano, Takashi Yamamoto, Hideki Hayashi, Emiko OgawaHiroshi Maegawa, Itsuko Miyazawa, Kiyoshi Murata, Kenichi Mitsunami, Kazuhiko Nozaki, Ikuo Tooyama, Akihiko Shiino, Teruhiko Tsuru, Hisakazu Ogita, Akio Shimizu, Naomi Miyamatsu, Toru Kita, Takeshi Kimura, Yoshihiko Nishio, Yasuyuki Nakamura, Tomonori Okamura, Akira Sekikawa, Emma Jm Barinas-Mitchell, Daniel Edmundowicz, Takayoshi Ohkubo, Atsushi Hozawa, Sendai Miyagi, Yoshitaka Murakami, Nagako Okuda, Yoshikuni Kita, Aya Higashiyama, Shinya Nagasawa, Koichiro Azuma, Masahiko Yanagita, Robert D. Abbott, Seiko Ohno, Naoyuki Takashima, Takashi Kadowaki, Yoshino Saito, Takahiro Ito, Atsushi Satoh, Masahiro Yamazoe

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Background: Excessive alcohol intake has been shown to be associated with cardiovascular disease via metabolic pathways. However, the relationship between alcohol intake and obesity has not been fully elucidated. We aimed to examine the association of alcohol consumption with fat deposition and anthropometric measures. Methods: From 2006–2008, we conducted a cross-sectional study in a population-based sample of Japanese men aged 40 through 79 years. Areas of abdominal visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT) were calculated using computed tomography imaging. Based on a questionnaire, we classified participants into five groups according to weekly alcohol consumption, excluding former drinkers: Non-drinkers (0 g=week), 0.1–160.9, 161–321.9, 322–482.9, and ≥483 g=week. Multivariable linear regression was used to estimate adjusted means of obesity indices for each group. Results: We analyzed 998 men (mean age and body mass index [BMI], 63.8 years and 23.6 kg=m2, respectively). Higher weekly alcohol consumption was strongly and significantly associated with higher abdominal VAT area, percentage of VAT, and VATto- SAT ratio (all P for trend <0.001), and also with waist circumferences and waist-to-hip ratio (P for trend = 0.042 and 0.007, respectively). These associations remained significant after further adjustment for BMI, whereas alcohol consumption had no significant association with abdominal SAT area. Conclusions: Higher alcohol consumption was associated with higher VAT area, VAT%, and VAT-to-SAT ratio, independent of confounders, including BMI, in general Japanese men. These results suggest that alcohol consumption may have a potential adverse effect on visceral fat deposition.

Original languageEnglish
Pages (from-to)205-212
Number of pages8
JournalJournal of epidemiology
Volume29
Issue number6
DOIs
Publication statusPublished - 2019 Jun

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Intra-Abdominal Fat
Alcohol Drinking
Epidemiologic Studies
Atherosclerosis
Fats
Subcutaneous Fat
Abdominal Fat
Body Mass Index
Obesity
Alcohols
Abdominal Subcutaneous Fat
Waist-Hip Ratio
Waist Circumference
Metabolic Networks and Pathways
Linear Models
Cardiovascular Diseases
Cross-Sectional Studies
Tomography
Population

Keywords

  • Alcohol consumption
  • Anthropometric obesity indice
  • Fat deposition
  • Visceral adipose tissue

ASJC Scopus subject areas

  • Epidemiology

Cite this

Association of alcohol consumption with fat deposition in a community-based sample of Japanese men : The Shiga epidemiological study of subclinical atherosclerosis (SESSA). / Sumi, Masaki; Hisamatsu, Takashi; Fujiyoshi, Akira; Kadota, Aya; Miyagawa, Naoko; Kondo, Keiko; Kadowaki, Sayaka; Suzuki, Sentaro; Torii, Sayuki; Zaid, Maryam; Sato, Atsushi; Arima, Hisatomi; Terada, Tomohiro; Miura, Katsuyuki; Ueshima, Hirotsugu; Horie, Minoru; Nakano, Yasutaka; Yamamoto, Takashi; Hayashi, Hideki; Ogawa, Emiko; Maegawa, Hiroshi; Miyazawa, Itsuko; Murata, Kiyoshi; Mitsunami, Kenichi; Nozaki, Kazuhiko; Tooyama, Ikuo; Shiino, Akihiko; Tsuru, Teruhiko; Ogita, Hisakazu; Shimizu, Akio; Miyamatsu, Naomi; Kita, Toru; Kimura, Takeshi; Nishio, Yoshihiko; Nakamura, Yasuyuki; Okamura, Tomonori; Sekikawa, Akira; Barinas-Mitchell, Emma Jm; Edmundowicz, Daniel; Ohkubo, Takayoshi; Hozawa, Atsushi; Miyagi, Sendai; Murakami, Yoshitaka; Okuda, Nagako; Kita, Yoshikuni; Higashiyama, Aya; Nagasawa, Shinya; Azuma, Koichiro; Yanagita, Masahiko; Abbott, Robert D.; Ohno, Seiko; Takashima, Naoyuki; Kadowaki, Takashi; Saito, Yoshino; Ito, Takahiro; Satoh, Atsushi; Yamazoe, Masahiro.

In: Journal of epidemiology, Vol. 29, No. 6, 06.2019, p. 205-212.

Research output: Contribution to journalArticle

Sumi, M, Hisamatsu, T, Fujiyoshi, A, Kadota, A, Miyagawa, N, Kondo, K, Kadowaki, S, Suzuki, S, Torii, S, Zaid, M, Sato, A, Arima, H, Terada, T, Miura, K, Ueshima, H, Horie, M, Nakano, Y, Yamamoto, T, Hayashi, H, Ogawa, E, Maegawa, H, Miyazawa, I, Murata, K, Mitsunami, K, Nozaki, K, Tooyama, I, Shiino, A, Tsuru, T, Ogita, H, Shimizu, A, Miyamatsu, N, Kita, T, Kimura, T, Nishio, Y, Nakamura, Y, Okamura, T, Sekikawa, A, Barinas-Mitchell, EJ, Edmundowicz, D, Ohkubo, T, Hozawa, A, Miyagi, S, Murakami, Y, Okuda, N, Kita, Y, Higashiyama, A, Nagasawa, S, Azuma, K, Yanagita, M, Abbott, RD, Ohno, S, Takashima, N, Kadowaki, T, Saito, Y, Ito, T, Satoh, A & Yamazoe, M 2019, 'Association of alcohol consumption with fat deposition in a community-based sample of Japanese men: The Shiga epidemiological study of subclinical atherosclerosis (SESSA)', Journal of epidemiology, vol. 29, no. 6, pp. 205-212. https://doi.org/10.2188/jea.JE20170191
Sumi, Masaki ; Hisamatsu, Takashi ; Fujiyoshi, Akira ; Kadota, Aya ; Miyagawa, Naoko ; Kondo, Keiko ; Kadowaki, Sayaka ; Suzuki, Sentaro ; Torii, Sayuki ; Zaid, Maryam ; Sato, Atsushi ; Arima, Hisatomi ; Terada, Tomohiro ; Miura, Katsuyuki ; Ueshima, Hirotsugu ; Horie, Minoru ; Nakano, Yasutaka ; Yamamoto, Takashi ; Hayashi, Hideki ; Ogawa, Emiko ; Maegawa, Hiroshi ; Miyazawa, Itsuko ; Murata, Kiyoshi ; Mitsunami, Kenichi ; Nozaki, Kazuhiko ; Tooyama, Ikuo ; Shiino, Akihiko ; Tsuru, Teruhiko ; Ogita, Hisakazu ; Shimizu, Akio ; Miyamatsu, Naomi ; Kita, Toru ; Kimura, Takeshi ; Nishio, Yoshihiko ; Nakamura, Yasuyuki ; Okamura, Tomonori ; Sekikawa, Akira ; Barinas-Mitchell, Emma Jm ; Edmundowicz, Daniel ; Ohkubo, Takayoshi ; Hozawa, Atsushi ; Miyagi, Sendai ; Murakami, Yoshitaka ; Okuda, Nagako ; Kita, Yoshikuni ; Higashiyama, Aya ; Nagasawa, Shinya ; Azuma, Koichiro ; Yanagita, Masahiko ; Abbott, Robert D. ; Ohno, Seiko ; Takashima, Naoyuki ; Kadowaki, Takashi ; Saito, Yoshino ; Ito, Takahiro ; Satoh, Atsushi ; Yamazoe, Masahiro. / Association of alcohol consumption with fat deposition in a community-based sample of Japanese men : The Shiga epidemiological study of subclinical atherosclerosis (SESSA). In: Journal of epidemiology. 2019 ; Vol. 29, No. 6. pp. 205-212.
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abstract = "Background: Excessive alcohol intake has been shown to be associated with cardiovascular disease via metabolic pathways. However, the relationship between alcohol intake and obesity has not been fully elucidated. We aimed to examine the association of alcohol consumption with fat deposition and anthropometric measures. Methods: From 2006–2008, we conducted a cross-sectional study in a population-based sample of Japanese men aged 40 through 79 years. Areas of abdominal visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT) were calculated using computed tomography imaging. Based on a questionnaire, we classified participants into five groups according to weekly alcohol consumption, excluding former drinkers: Non-drinkers (0 g=week), 0.1–160.9, 161–321.9, 322–482.9, and ≥483 g=week. Multivariable linear regression was used to estimate adjusted means of obesity indices for each group. Results: We analyzed 998 men (mean age and body mass index [BMI], 63.8 years and 23.6 kg=m2, respectively). Higher weekly alcohol consumption was strongly and significantly associated with higher abdominal VAT area, percentage of VAT, and VATto- SAT ratio (all P for trend <0.001), and also with waist circumferences and waist-to-hip ratio (P for trend = 0.042 and 0.007, respectively). These associations remained significant after further adjustment for BMI, whereas alcohol consumption had no significant association with abdominal SAT area. Conclusions: Higher alcohol consumption was associated with higher VAT area, VAT{\%}, and VAT-to-SAT ratio, independent of confounders, including BMI, in general Japanese men. These results suggest that alcohol consumption may have a potential adverse effect on visceral fat deposition.",
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TY - JOUR

T1 - Association of alcohol consumption with fat deposition in a community-based sample of Japanese men

T2 - The Shiga epidemiological study of subclinical atherosclerosis (SESSA)

AU - Sumi, Masaki

AU - Hisamatsu, Takashi

AU - Fujiyoshi, Akira

AU - Kadota, Aya

AU - Miyagawa, Naoko

AU - Kondo, Keiko

AU - Kadowaki, Sayaka

AU - Suzuki, Sentaro

AU - Torii, Sayuki

AU - Zaid, Maryam

AU - Sato, Atsushi

AU - Arima, Hisatomi

AU - Terada, Tomohiro

AU - Miura, Katsuyuki

AU - Ueshima, Hirotsugu

AU - Horie, Minoru

AU - Nakano, Yasutaka

AU - Yamamoto, Takashi

AU - Hayashi, Hideki

AU - Ogawa, Emiko

AU - Maegawa, Hiroshi

AU - Miyazawa, Itsuko

AU - Murata, Kiyoshi

AU - Mitsunami, Kenichi

AU - Nozaki, Kazuhiko

AU - Tooyama, Ikuo

AU - Shiino, Akihiko

AU - Tsuru, Teruhiko

AU - Ogita, Hisakazu

AU - Shimizu, Akio

AU - Miyamatsu, Naomi

AU - Kita, Toru

AU - Kimura, Takeshi

AU - Nishio, Yoshihiko

AU - Nakamura, Yasuyuki

AU - Okamura, Tomonori

AU - Sekikawa, Akira

AU - Barinas-Mitchell, Emma Jm

AU - Edmundowicz, Daniel

AU - Ohkubo, Takayoshi

AU - Hozawa, Atsushi

AU - Miyagi, Sendai

AU - Murakami, Yoshitaka

AU - Okuda, Nagako

AU - Kita, Yoshikuni

AU - Higashiyama, Aya

AU - Nagasawa, Shinya

AU - Azuma, Koichiro

AU - Yanagita, Masahiko

AU - Abbott, Robert D.

AU - Ohno, Seiko

AU - Takashima, Naoyuki

AU - Kadowaki, Takashi

AU - Saito, Yoshino

AU - Ito, Takahiro

AU - Satoh, Atsushi

AU - Yamazoe, Masahiro

PY - 2019/6

Y1 - 2019/6

N2 - Background: Excessive alcohol intake has been shown to be associated with cardiovascular disease via metabolic pathways. However, the relationship between alcohol intake and obesity has not been fully elucidated. We aimed to examine the association of alcohol consumption with fat deposition and anthropometric measures. Methods: From 2006–2008, we conducted a cross-sectional study in a population-based sample of Japanese men aged 40 through 79 years. Areas of abdominal visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT) were calculated using computed tomography imaging. Based on a questionnaire, we classified participants into five groups according to weekly alcohol consumption, excluding former drinkers: Non-drinkers (0 g=week), 0.1–160.9, 161–321.9, 322–482.9, and ≥483 g=week. Multivariable linear regression was used to estimate adjusted means of obesity indices for each group. Results: We analyzed 998 men (mean age and body mass index [BMI], 63.8 years and 23.6 kg=m2, respectively). Higher weekly alcohol consumption was strongly and significantly associated with higher abdominal VAT area, percentage of VAT, and VATto- SAT ratio (all P for trend <0.001), and also with waist circumferences and waist-to-hip ratio (P for trend = 0.042 and 0.007, respectively). These associations remained significant after further adjustment for BMI, whereas alcohol consumption had no significant association with abdominal SAT area. Conclusions: Higher alcohol consumption was associated with higher VAT area, VAT%, and VAT-to-SAT ratio, independent of confounders, including BMI, in general Japanese men. These results suggest that alcohol consumption may have a potential adverse effect on visceral fat deposition.

AB - Background: Excessive alcohol intake has been shown to be associated with cardiovascular disease via metabolic pathways. However, the relationship between alcohol intake and obesity has not been fully elucidated. We aimed to examine the association of alcohol consumption with fat deposition and anthropometric measures. Methods: From 2006–2008, we conducted a cross-sectional study in a population-based sample of Japanese men aged 40 through 79 years. Areas of abdominal visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT) were calculated using computed tomography imaging. Based on a questionnaire, we classified participants into five groups according to weekly alcohol consumption, excluding former drinkers: Non-drinkers (0 g=week), 0.1–160.9, 161–321.9, 322–482.9, and ≥483 g=week. Multivariable linear regression was used to estimate adjusted means of obesity indices for each group. Results: We analyzed 998 men (mean age and body mass index [BMI], 63.8 years and 23.6 kg=m2, respectively). Higher weekly alcohol consumption was strongly and significantly associated with higher abdominal VAT area, percentage of VAT, and VATto- SAT ratio (all P for trend <0.001), and also with waist circumferences and waist-to-hip ratio (P for trend = 0.042 and 0.007, respectively). These associations remained significant after further adjustment for BMI, whereas alcohol consumption had no significant association with abdominal SAT area. Conclusions: Higher alcohol consumption was associated with higher VAT area, VAT%, and VAT-to-SAT ratio, independent of confounders, including BMI, in general Japanese men. These results suggest that alcohol consumption may have a potential adverse effect on visceral fat deposition.

KW - Alcohol consumption

KW - Anthropometric obesity indice

KW - Fat deposition

KW - Visceral adipose tissue

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